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Gene: BMT2 |
Gene summary for BMT2 |
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Gene information | Species | Human | Gene symbol | BMT2 | Gene ID | 154743 |
Gene name | base methyltransferase of 25S rRNA 2 homolog | |
Gene Alias | C7orf60 | |
Cytomap | 7q31.1 | |
Gene Type | protein-coding | GO ID | GO:0006950 | UniProtAcc | Q1RMZ1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
154743 | BMT2 | S014 | Human | Liver | HCC | 5.71e-08 | 2.66e-01 | 0.2254 |
154743 | BMT2 | S016 | Human | Liver | HCC | 6.73e-07 | 2.17e-01 | 0.2243 |
154743 | BMT2 | S027 | Human | Liver | HCC | 6.88e-10 | 5.84e-01 | 0.2446 |
154743 | BMT2 | S028 | Human | Liver | HCC | 7.29e-17 | 5.64e-01 | 0.2503 |
154743 | BMT2 | S029 | Human | Liver | HCC | 4.60e-12 | 4.56e-01 | 0.2581 |
154743 | BMT2 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 3.82e-12 | 4.58e-01 | -0.0166 |
154743 | BMT2 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.49e-10 | 4.16e-01 | -0.0132 |
154743 | BMT2 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 3.60e-12 | 4.20e-01 | -0.013 |
154743 | BMT2 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 2.29e-09 | 4.26e-01 | -0.0121 |
154743 | BMT2 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 6.59e-04 | 5.86e-01 | -0.0961 |
154743 | BMT2 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 2.62e-04 | 5.99e-01 | -0.0876 |
154743 | BMT2 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 4.77e-05 | 5.80e-01 | -0.0809 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003166722 | Liver | HCC | response to nutrient levels | 276/7958 | 474/18723 | 2.30e-12 | 1.08e-10 | 276 |
GO:007149622 | Liver | HCC | cellular response to external stimulus | 191/7958 | 320/18723 | 3.40e-10 | 1.13e-08 | 191 |
GO:003166812 | Liver | HCC | cellular response to extracellular stimulus | 149/7958 | 246/18723 | 7.35e-09 | 1.86e-07 | 149 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:004259421 | Liver | HCC | response to starvation | 121/7958 | 197/18723 | 6.08e-08 | 1.28e-06 | 121 |
GO:003166912 | Liver | HCC | cellular response to nutrient levels | 130/7958 | 215/18723 | 7.52e-08 | 1.51e-06 | 130 |
GO:000926712 | Liver | HCC | cellular response to starvation | 94/7958 | 156/18723 | 5.61e-06 | 6.95e-05 | 94 |
GO:00319291 | Liver | HCC | TOR signaling | 78/7958 | 126/18723 | 8.49e-06 | 9.97e-05 | 78 |
GO:0032006 | Liver | HCC | regulation of TOR signaling | 63/7958 | 104/18723 | 1.50e-04 | 1.20e-03 | 63 |
GO:19909281 | Liver | HCC | response to amino acid starvation | 33/7958 | 49/18723 | 3.86e-04 | 2.62e-03 | 33 |
GO:00341981 | Liver | HCC | cellular response to amino acid starvation | 30/7958 | 46/18723 | 1.56e-03 | 8.23e-03 | 30 |
GO:00714968 | Lung | IAC | cellular response to external stimulus | 60/2061 | 320/18723 | 2.50e-05 | 6.76e-04 | 60 |
GO:00316687 | Lung | IAC | cellular response to extracellular stimulus | 48/2061 | 246/18723 | 5.62e-05 | 1.24e-03 | 48 |
GO:00316696 | Lung | IAC | cellular response to nutrient levels | 41/2061 | 215/18723 | 3.13e-04 | 4.98e-03 | 41 |
GO:00316678 | Lung | IAC | response to nutrient levels | 76/2061 | 474/18723 | 4.87e-04 | 7.08e-03 | 76 |
GO:00092676 | Lung | IAC | cellular response to starvation | 29/2061 | 156/18723 | 3.26e-03 | 2.80e-02 | 29 |
GO:00425946 | Lung | IAC | response to starvation | 34/2061 | 197/18723 | 5.29e-03 | 4.00e-02 | 34 |
GO:003166813 | Lung | AIS | cellular response to extracellular stimulus | 41/1849 | 246/18723 | 5.90e-04 | 9.03e-03 | 41 |
GO:007149613 | Lung | AIS | cellular response to external stimulus | 50/1849 | 320/18723 | 7.41e-04 | 1.07e-02 | 50 |
GO:003166913 | Lung | AIS | cellular response to nutrient levels | 35/1849 | 215/18723 | 2.15e-03 | 2.31e-02 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BMT2 | SNV | Missense_Mutation | novel | c.649G>C | p.Asp217His | p.D217H | Q1RMZ1 | protein_coding | deleterious(0) | benign(0.411) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
BMT2 | SNV | Missense_Mutation | c.1154G>C | p.Gly385Ala | p.G385A | Q1RMZ1 | protein_coding | deleterious_low_confidence(0.03) | benign(0.22) | TCGA-86-7955-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | PD | |
BMT2 | SNV | Missense_Mutation | c.691N>A | p.Asp231Asn | p.D231N | Q1RMZ1 | protein_coding | tolerated(0.11) | benign(0.096) | TCGA-91-6828-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BMT2 | SNV | Missense_Mutation | c.631N>T | p.Pro211Ser | p.P211S | Q1RMZ1 | protein_coding | tolerated(0.1) | possibly_damaging(0.549) | TCGA-91-6848-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR | |
BMT2 | SNV | Missense_Mutation | novel | c.918N>T | p.Lys306Asn | p.K306N | Q1RMZ1 | protein_coding | deleterious(0.01) | possibly_damaging(0.825) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
BMT2 | SNV | Missense_Mutation | novel | c.962N>C | p.Ile321Thr | p.I321T | Q1RMZ1 | protein_coding | tolerated(0.46) | benign(0) | TCGA-MN-A4N1-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
BMT2 | SNV | Missense_Mutation | novel | c.886G>C | p.Ala296Pro | p.A296P | Q1RMZ1 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BMT2 | SNV | Missense_Mutation | novel | c.500N>C | p.Arg167Thr | p.R167T | Q1RMZ1 | protein_coding | deleterious(0.04) | possibly_damaging(0.528) | TCGA-94-8491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
BMT2 | insertion | Frame_Shift_Ins | novel | c.716_717insCT | p.Val240LeufsTer29 | p.V240Lfs*29 | Q1RMZ1 | protein_coding | TCGA-55-A493-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
BMT2 | insertion | Nonsense_Mutation | novel | c.714_715insTACTAACCAAGT | p.Phe238_His239insTyrTerProSer | p.F238_H239insY*PS | Q1RMZ1 | protein_coding | TCGA-55-A493-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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