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Gene: B4GALNT3 |
Gene summary for B4GALNT3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | B4GALNT3 | Gene ID | 283358 |
| Gene name | beta-1,4-N-acetyl-galactosaminyltransferase 3 | |
| Gene Alias | B4GALNT3 | |
| Cytomap | 12p13.33 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6L9W6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 283358 | B4GALNT3 | CCI_1 | Human | Cervix | CC | 9.15e-10 | 8.77e-01 | 0.528 |
| 283358 | B4GALNT3 | CCI_2 | Human | Cervix | CC | 2.36e-08 | 6.12e-01 | 0.5249 |
| 283358 | B4GALNT3 | CCI_3 | Human | Cervix | CC | 3.39e-04 | 5.73e-01 | 0.516 |
| 283358 | B4GALNT3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.98e-17 | -6.81e-01 | 0.0155 |
| 283358 | B4GALNT3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.05e-04 | -9.07e-01 | 0.0216 |
| 283358 | B4GALNT3 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.33e-03 | 6.45e-01 | -0.2602 |
| 283358 | B4GALNT3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.08e-05 | -4.57e-01 | -0.1207 |
| 283358 | B4GALNT3 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.86e-12 | -5.88e-01 | 0.096 |
| 283358 | B4GALNT3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.69e-02 | -5.85e-01 | 0.0528 |
| 283358 | B4GALNT3 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.09e-03 | -7.95e-01 | 0.0131 |
| 283358 | B4GALNT3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.26e-07 | -6.45e-01 | 0.0338 |
| 283358 | B4GALNT3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.96e-09 | -4.93e-01 | 0.0674 |
| 283358 | B4GALNT3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.14e-02 | -4.99e-01 | 0.0588 |
| 283358 | B4GALNT3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.31e-27 | -7.12e-01 | 0.294 |
| 283358 | B4GALNT3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.96e-02 | -2.68e-01 | 0.3859 |
| 283358 | B4GALNT3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.14e-09 | -5.14e-01 | 0.3005 |
| 283358 | B4GALNT3 | F007 | Human | Colorectum | FAP | 2.34e-13 | -7.30e-01 | 0.1176 |
| 283358 | B4GALNT3 | A002-C-010 | Human | Colorectum | FAP | 1.24e-13 | -5.56e-01 | 0.242 |
| 283358 | B4GALNT3 | A001-C-207 | Human | Colorectum | FAP | 5.95e-04 | -3.80e-01 | 0.1278 |
| 283358 | B4GALNT3 | A015-C-203 | Human | Colorectum | FAP | 1.97e-35 | -5.95e-01 | -0.1294 |
| Page: 1 2 3 4 5 6 7 8 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa00513 | Colorectum | MSS | Various types of N-glycan biosynthesis | 16/1875 | 42/8465 | 1.39e-02 | 4.53e-02 | 2.77e-02 | 16 |
| hsa005131 | Colorectum | MSS | Various types of N-glycan biosynthesis | 16/1875 | 42/8465 | 1.39e-02 | 4.53e-02 | 2.77e-02 | 16 |
| hsa005136 | Esophagus | ESCC | Various types of N-glycan biosynthesis | 31/4205 | 42/8465 | 1.23e-03 | 3.78e-03 | 1.93e-03 | 31 |
| hsa0051313 | Esophagus | ESCC | Various types of N-glycan biosynthesis | 31/4205 | 42/8465 | 1.23e-03 | 3.78e-03 | 1.93e-03 | 31 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| B4GALNT3 | SNV | Missense_Mutation | rs777975379 | c.1418G>A | p.Arg473Gln | p.R473Q | Q6L9W6 | protein_coding | tolerated(0.2) | benign(0.325) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
| B4GALNT3 | SNV | Missense_Mutation | c.1915N>G | p.Ser639Gly | p.S639G | Q6L9W6 | protein_coding | deleterious(0) | possibly_damaging(0.49) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| B4GALNT3 | SNV | Missense_Mutation | rs774931975 | c.2099G>A | p.Arg700His | p.R700H | Q6L9W6 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-D1-A0ZZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | SD |
| B4GALNT3 | SNV | Missense_Mutation | c.2378N>A | p.Pro793His | p.P793H | Q6L9W6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| B4GALNT3 | SNV | Missense_Mutation | novel | c.1839N>T | p.Glu613Asp | p.E613D | Q6L9W6 | protein_coding | tolerated(0.22) | benign(0.001) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
| B4GALNT3 | SNV | Missense_Mutation | novel | c.2791N>T | p.Leu931Phe | p.L931F | Q6L9W6 | protein_coding | tolerated(0.57) | possibly_damaging(0.836) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| B4GALNT3 | SNV | Missense_Mutation | novel | c.1161G>T | p.Glu387Asp | p.E387D | Q6L9W6 | protein_coding | deleterious(0.03) | benign(0.065) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
| B4GALNT3 | SNV | Missense_Mutation | novel | c.2731N>T | p.His911Tyr | p.H911Y | Q6L9W6 | protein_coding | tolerated(0.08) | possibly_damaging(0.699) | TCGA-PG-A6IB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| B4GALNT3 | deletion | Frame_Shift_Del | c.2749delC | p.Gln917SerfsTer9 | p.Q917Sfs*9 | Q6L9W6 | protein_coding | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
| B4GALNT3 | deletion | In_Frame_Del | novel | c.1287_1289delTCT | p.Leu430del | p.L430del | Q6L9W6 | protein_coding | TCGA-E6-A2P9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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