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Gene: B4GALNT2 |
Gene summary for B4GALNT2 |
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Gene information | Species | Human | Gene symbol | B4GALNT2 | Gene ID | 124872 |
Gene name | beta-1,4-N-acetyl-galactosaminyltransferase 2 | |
Gene Alias | B4GALT | |
Cytomap | 17q21.32 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q8NHY0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
124872 | B4GALNT2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.19e-07 | 5.40e-01 | -0.1808 |
124872 | B4GALNT2 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.24e-11 | 8.26e-01 | -0.1088 |
124872 | B4GALNT2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.20e-14 | 5.16e-01 | -0.1954 |
124872 | B4GALNT2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.12e-12 | 5.68e-01 | -0.1207 |
124872 | B4GALNT2 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.02e-15 | 9.21e-01 | -0.1526 |
124872 | B4GALNT2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.63e-07 | 5.20e-01 | -0.1464 |
124872 | B4GALNT2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.56e-10 | 6.57e-01 | -0.1001 |
124872 | B4GALNT2 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.26e-10 | 9.12e-01 | -0.0842 |
124872 | B4GALNT2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.40e-09 | -2.42e-01 | 0.294 |
124872 | B4GALNT2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.87e-03 | -2.23e-01 | 0.3859 |
124872 | B4GALNT2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.22e-04 | -2.31e-01 | 0.3005 |
124872 | B4GALNT2 | A001-C-207 | Human | Colorectum | FAP | 1.14e-02 | -2.48e-01 | 0.1278 |
124872 | B4GALNT2 | A015-C-203 | Human | Colorectum | FAP | 2.71e-02 | -9.33e-02 | -0.1294 |
124872 | B4GALNT2 | A002-C-203 | Human | Colorectum | FAP | 2.81e-06 | -2.38e-01 | 0.2786 |
124872 | B4GALNT2 | A001-C-108 | Human | Colorectum | FAP | 6.26e-07 | -2.24e-01 | -0.0272 |
124872 | B4GALNT2 | A002-C-021 | Human | Colorectum | FAP | 7.14e-03 | -2.24e-01 | 0.1171 |
124872 | B4GALNT2 | A001-C-104 | Human | Colorectum | FAP | 7.35e-03 | -2.10e-01 | 0.0184 |
124872 | B4GALNT2 | A015-C-106 | Human | Colorectum | FAP | 7.07e-03 | -1.88e-01 | -0.0511 |
124872 | B4GALNT2 | A015-C-104 | Human | Colorectum | FAP | 9.97e-03 | -1.35e-01 | -0.1899 |
124872 | B4GALNT2 | A015-C-202 | Human | Colorectum | FAP | 3.72e-05 | 3.05e-01 | -0.0849 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0018279 | Colorectum | AD | protein N-linked glycosylation via asparagine | 15/3918 | 23/18723 | 5.47e-06 | 1.40e-04 | 15 |
GO:0018196 | Colorectum | AD | peptidyl-asparagine modification | 15/3918 | 24/18723 | 1.18e-05 | 2.62e-04 | 15 |
GO:0030258 | Colorectum | AD | lipid modification | 67/3918 | 212/18723 | 1.66e-04 | 2.27e-03 | 67 |
GO:0006487 | Colorectum | AD | protein N-linked glycosylation | 25/3918 | 65/18723 | 9.12e-04 | 8.71e-03 | 25 |
GO:0009225 | Colorectum | AD | nucleotide-sugar metabolic process | 16/3918 | 36/18723 | 1.27e-03 | 1.12e-02 | 16 |
GO:0006486 | Colorectum | AD | protein glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0043413 | Colorectum | AD | macromolecule glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0070085 | Colorectum | AD | glycosylation | 67/3918 | 240/18723 | 5.78e-03 | 3.67e-02 | 67 |
GO:0007162 | Colorectum | SER | negative regulation of cell adhesion | 68/2897 | 303/18723 | 8.02e-04 | 1.01e-02 | 68 |
GO:00182791 | Colorectum | SER | protein N-linked glycosylation via asparagine | 9/2897 | 23/18723 | 5.20e-03 | 3.95e-02 | 9 |
GO:00302581 | Colorectum | SER | lipid modification | 47/2897 | 212/18723 | 6.01e-03 | 4.38e-02 | 47 |
GO:0022408 | Colorectum | SER | negative regulation of cell-cell adhesion | 44/2897 | 196/18723 | 6.08e-03 | 4.42e-02 | 44 |
GO:00092251 | Colorectum | SER | nucleotide-sugar metabolic process | 12/2897 | 36/18723 | 6.11e-03 | 4.42e-02 | 12 |
GO:00181961 | Colorectum | SER | peptidyl-asparagine modification | 9/2897 | 24/18723 | 7.19e-03 | 4.99e-02 | 9 |
GO:00182792 | Colorectum | MSS | protein N-linked glycosylation via asparagine | 13/3467 | 23/18723 | 5.21e-05 | 9.31e-04 | 13 |
GO:00181962 | Colorectum | MSS | peptidyl-asparagine modification | 13/3467 | 24/18723 | 9.44e-05 | 1.49e-03 | 13 |
GO:00064871 | Colorectum | MSS | protein N-linked glycosylation | 23/3467 | 65/18723 | 9.47e-04 | 9.54e-03 | 23 |
GO:00302582 | Colorectum | MSS | lipid modification | 57/3467 | 212/18723 | 1.64e-03 | 1.49e-02 | 57 |
GO:00092252 | Colorectum | MSS | nucleotide-sugar metabolic process | 14/3467 | 36/18723 | 3.40e-03 | 2.56e-02 | 14 |
GO:00302583 | Colorectum | FAP | lipid modification | 52/2622 | 212/18723 | 2.84e-05 | 6.49e-04 | 52 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
B4GALNT2 | SNV | Missense_Mutation | rs752552356 | c.908G>A | p.Arg303His | p.R303H | Q8NHY0 | protein_coding | deleterious(0.04) | possibly_damaging(0.719) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
B4GALNT2 | SNV | Missense_Mutation | novel | c.1230G>T | p.Lys410Asn | p.K410N | Q8NHY0 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
B4GALNT2 | SNV | Missense_Mutation | novel | c.456N>G | p.Phe152Leu | p.F152L | Q8NHY0 | protein_coding | tolerated(0.79) | benign(0) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
B4GALNT2 | SNV | Missense_Mutation | novel | c.1291N>A | p.Leu431Met | p.L431M | Q8NHY0 | protein_coding | tolerated(0.22) | benign(0.025) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
B4GALNT2 | SNV | Missense_Mutation | novel | c.1103N>G | p.His368Arg | p.H368R | Q8NHY0 | protein_coding | deleterious(0.01) | benign(0.193) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
B4GALNT2 | SNV | Missense_Mutation | novel | c.1342N>A | p.Ala448Thr | p.A448T | Q8NHY0 | protein_coding | deleterious(0.05) | benign(0.062) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
B4GALNT2 | deletion | Frame_Shift_Del | novel | c.665delN | p.Val224SerfsTer6 | p.V224Sfs*6 | Q8NHY0 | protein_coding | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
B4GALNT2 | SNV | Missense_Mutation | c.1531N>T | p.Gly511Trp | p.G511W | Q8NHY0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-HP-A5N0-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
B4GALNT2 | SNV | Missense_Mutation | novel | c.1085N>C | p.Leu362Pro | p.L362P | Q8NHY0 | protein_coding | tolerated(0.14) | possibly_damaging(0.852) | TCGA-49-AAR9-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
B4GALNT2 | SNV | Missense_Mutation | novel | c.640N>A | p.Gly214Ser | p.G214S | Q8NHY0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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