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Gene: B3GNT9 |
Gene summary for B3GNT9 |
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Gene information | Species | Human | Gene symbol | B3GNT9 | Gene ID | 84752 |
Gene name | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 | |
Gene Alias | B3GNT9 | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | Q6UX72 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84752 | B3GNT9 | C21 | Human | Oral cavity | OSCC | 1.68e-06 | 2.85e-01 | 0.2678 |
84752 | B3GNT9 | C30 | Human | Oral cavity | OSCC | 1.81e-23 | 9.96e-01 | 0.3055 |
84752 | B3GNT9 | C57 | Human | Oral cavity | OSCC | 2.26e-02 | 1.63e-01 | 0.1679 |
84752 | B3GNT9 | C06 | Human | Oral cavity | OSCC | 1.71e-05 | 5.27e-01 | 0.2699 |
84752 | B3GNT9 | C08 | Human | Oral cavity | OSCC | 1.20e-09 | 1.89e-01 | 0.1919 |
84752 | B3GNT9 | C09 | Human | Oral cavity | OSCC | 2.35e-02 | 1.03e-01 | 0.1431 |
84752 | B3GNT9 | LN46 | Human | Oral cavity | OSCC | 9.12e-05 | 2.29e-01 | 0.1666 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00091001 | Oral cavity | OSCC | glycoprotein metabolic process | 185/7305 | 387/18723 | 2.37e-04 | 1.54e-03 | 185 |
GO:00091011 | Oral cavity | OSCC | glycoprotein biosynthetic process | 151/7305 | 317/18723 | 1.01e-03 | 5.26e-03 | 151 |
GO:00064864 | Oral cavity | OSCC | protein glycosylation | 111/7305 | 226/18723 | 1.22e-03 | 6.10e-03 | 111 |
GO:00434134 | Oral cavity | OSCC | macromolecule glycosylation | 111/7305 | 226/18723 | 1.22e-03 | 6.10e-03 | 111 |
GO:00700853 | Oral cavity | OSCC | glycosylation | 117/7305 | 240/18723 | 1.29e-03 | 6.42e-03 | 117 |
GO:00160513 | Oral cavity | OSCC | carbohydrate biosynthetic process | 97/7305 | 202/18723 | 5.50e-03 | 2.13e-02 | 97 |
GO:00442625 | Oral cavity | OSCC | cellular carbohydrate metabolic process | 130/7305 | 283/18723 | 9.98e-03 | 3.49e-02 | 130 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
B3GNT9 | SNV | Missense_Mutation | rs376245125 | c.788N>T | p.Pro263Leu | p.P263L | Q6UX72 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-XQ-A8TA-01 | Prostate | prostate adenocarcinoma | Male | <65 | 10 | Unknown | Unknown | PD |
B3GNT9 | SNV | Missense_Mutation | c.230C>T | p.Thr77Met | p.T77M | Q6UX72 | protein_coding | tolerated(0.25) | probably_damaging(0.94) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
B3GNT9 | SNV | Missense_Mutation | novel | c.252N>A | p.Phe84Leu | p.F84L | Q6UX72 | protein_coding | deleterious(0.01) | benign(0.052) | TCGA-VQ-AA6F-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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