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Gene: AUP1 |
Gene summary for AUP1 |
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Gene information | Species | Human | Gene symbol | AUP1 | Gene ID | 550 |
Gene name | AUP1 lipid droplet regulating VLDL assembly factor | |
Gene Alias | AUP1 | |
Cytomap | 2p13.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9Y679 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
550 | AUP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.18e-05 | 3.34e-01 | -0.1808 |
550 | AUP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.90e-05 | 3.16e-01 | -0.0811 |
550 | AUP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.47e-06 | 2.19e-01 | -0.1088 |
550 | AUP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.33e-14 | 3.47e-01 | -0.1954 |
550 | AUP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.16e-04 | 3.31e-01 | -0.1207 |
550 | AUP1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.98e-06 | 2.53e-01 | -0.1526 |
550 | AUP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.53e-11 | 4.63e-01 | -0.1464 |
550 | AUP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.20e-06 | 2.60e-01 | -0.1001 |
550 | AUP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.53e-09 | 3.72e-01 | -0.059 |
550 | AUP1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.52e-04 | 2.83e-01 | -0.1462 |
550 | AUP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.44e-10 | 3.52e-01 | 0.096 |
550 | AUP1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.84e-03 | 3.09e-01 | 0.0446 |
550 | AUP1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.89e-04 | 6.18e-01 | 0.0131 |
550 | AUP1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.07e-02 | 3.95e-01 | -0.0177 |
550 | AUP1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.06e-05 | 2.98e-01 | 0.0338 |
550 | AUP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.27e-05 | 2.39e-01 | 0.0674 |
550 | AUP1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.94e-02 | 2.87e-01 | 0.0112 |
550 | AUP1 | HTA11_11156_2000001011 | Human | Colorectum | AD | 1.98e-03 | 4.62e-01 | 0.0397 |
550 | AUP1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.15e-03 | 3.02e-01 | 0.0588 |
550 | AUP1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.18e-02 | 2.64e-01 | 0.294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
GO:0034976 | Colorectum | AD | response to endoplasmic reticulum stress | 90/3918 | 256/18723 | 8.48e-08 | 4.28e-06 | 90 |
GO:0061912 | Colorectum | AD | selective autophagy | 29/3918 | 68/18723 | 4.20e-05 | 7.39e-04 | 29 |
GO:0035966 | Colorectum | AD | response to topologically incorrect protein | 54/3918 | 159/18723 | 8.85e-05 | 1.36e-03 | 54 |
GO:0035967 | Colorectum | AD | cellular response to topologically incorrect protein | 42/3918 | 116/18723 | 1.04e-04 | 1.56e-03 | 42 |
GO:0006515 | Colorectum | AD | protein quality control for misfolded or incompletely synthesized proteins | 14/3918 | 28/18723 | 6.01e-04 | 6.33e-03 | 14 |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0071712 | Colorectum | AD | ER-associated misfolded protein catabolic process | 7/3918 | 12/18723 | 5.09e-03 | 3.38e-02 | 7 |
GO:0036503 | Colorectum | AD | ERAD pathway | 34/3918 | 107/18723 | 5.57e-03 | 3.63e-02 | 34 |
GO:00104981 | Colorectum | SER | proteasomal protein catabolic process | 132/2897 | 490/18723 | 3.08e-11 | 5.55e-09 | 132 |
GO:00349761 | Colorectum | SER | response to endoplasmic reticulum stress | 74/2897 | 256/18723 | 3.01e-08 | 2.05e-06 | 74 |
GO:00431611 | Colorectum | SER | proteasome-mediated ubiquitin-dependent protein catabolic process | 105/2897 | 412/18723 | 7.48e-08 | 4.70e-06 | 105 |
GO:00162361 | Colorectum | SER | macroautophagy | 79/2897 | 291/18723 | 1.97e-07 | 1.10e-05 | 79 |
GO:00359661 | Colorectum | SER | response to topologically incorrect protein | 46/2897 | 159/18723 | 1.14e-05 | 3.63e-04 | 46 |
GO:00359671 | Colorectum | SER | cellular response to topologically incorrect protein | 36/2897 | 116/18723 | 1.88e-05 | 5.51e-04 | 36 |
GO:00619121 | Colorectum | SER | selective autophagy | 24/2897 | 68/18723 | 4.60e-05 | 1.15e-03 | 24 |
GO:00065151 | Colorectum | SER | protein quality control for misfolded or incompletely synthesized proteins | 12/2897 | 28/18723 | 4.92e-04 | 7.02e-03 | 12 |
GO:0030970 | Colorectum | SER | retrograde protein transport, ER to cytosol | 12/2897 | 29/18723 | 7.22e-04 | 9.44e-03 | 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AUP1 | SNV | Missense_Mutation | c.1077G>T | p.Lys359Asn | p.K359N | Q9Y679 | protein_coding | tolerated(0.16) | benign(0.37) | TCGA-55-7227-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | SD | |
AUP1 | SNV | Missense_Mutation | rs757009295 | c.829C>T | p.Arg277Cys | p.R277C | Q9Y679 | protein_coding | tolerated(0.18) | benign(0.169) | TCGA-CR-7402-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
AUP1 | SNV | Missense_Mutation | novel | c.1192N>G | p.Arg398Gly | p.R398G | Q9Y679 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CV-7421-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AUP1 | SNV | Missense_Mutation | c.925N>T | p.Pro309Ser | p.P309S | Q9Y679 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AUP1 | SNV | Missense_Mutation | c.572N>G | p.Gln191Arg | p.Q191R | Q9Y679 | protein_coding | tolerated(0.72) | benign(0) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
AUP1 | insertion | Frame_Shift_Ins | novel | c.538_539insT | p.Ser180PhefsTer59 | p.S180Ffs*59 | Q9Y679 | protein_coding | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
AUP1 | deletion | Frame_Shift_Del | c.409delG | p.Glu137SerfsTer63 | p.E137Sfs*63 | Q9Y679 | protein_coding | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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