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Gene: ATP9A |
Gene summary for ATP9A |
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Gene information | Species | Human | Gene symbol | ATP9A | Gene ID | 10079 |
Gene name | ATPase phospholipid transporting 9A (putative) | |
Gene Alias | ATPIIA | |
Cytomap | 20q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B4DR18 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10079 | ATP9A | CCI_1 | Human | Cervix | CC | 1.76e-04 | 5.23e-01 | 0.528 |
10079 | ATP9A | CCI_3 | Human | Cervix | CC | 2.33e-11 | 6.78e-01 | 0.516 |
10079 | ATP9A | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.61e-08 | 7.10e-01 | -0.0811 |
10079 | ATP9A | HTA11_347_2000001011 | Human | Colorectum | AD | 5.07e-13 | 6.64e-01 | -0.1954 |
10079 | ATP9A | HTA11_411_2000001011 | Human | Colorectum | SER | 8.68e-04 | 8.07e-01 | -0.2602 |
10079 | ATP9A | HTA11_696_2000001011 | Human | Colorectum | AD | 6.27e-03 | 3.83e-01 | -0.1464 |
10079 | ATP9A | HTA11_866_2000001011 | Human | Colorectum | AD | 8.15e-05 | 4.35e-01 | -0.1001 |
10079 | ATP9A | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.01e-03 | 5.00e-01 | -0.059 |
10079 | ATP9A | HTA11_866_3004761011 | Human | Colorectum | AD | 1.29e-06 | 6.06e-01 | 0.096 |
10079 | ATP9A | HTA11_6818_2000001011 | Human | Colorectum | AD | 5.41e-05 | 8.07e-01 | 0.0112 |
10079 | ATP9A | HTA11_6818_2000001021 | Human | Colorectum | AD | 8.16e-06 | 6.01e-01 | 0.0588 |
10079 | ATP9A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.97e-21 | 1.09e+00 | 0.281 |
10079 | ATP9A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.78e-18 | 1.05e+00 | 0.3859 |
10079 | ATP9A | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.92e-11 | 1.16e+00 | 0.2585 |
10079 | ATP9A | F007 | Human | Colorectum | FAP | 1.84e-03 | 2.89e-01 | 0.1176 |
10079 | ATP9A | A015-C-203 | Human | Colorectum | FAP | 8.40e-26 | -6.13e-02 | -0.1294 |
10079 | ATP9A | A015-C-204 | Human | Colorectum | FAP | 1.30e-03 | 1.77e-02 | -0.0228 |
10079 | ATP9A | A014-C-040 | Human | Colorectum | FAP | 5.66e-03 | -5.52e-02 | -0.1184 |
10079 | ATP9A | A002-C-201 | Human | Colorectum | FAP | 2.14e-10 | 3.69e-02 | 0.0324 |
10079 | ATP9A | A001-C-119 | Human | Colorectum | FAP | 2.99e-11 | 3.87e-01 | -0.1557 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00323868 | Cervix | CC | regulation of intracellular transport | 71/2311 | 337/18723 | 3.70e-06 | 9.74e-05 | 71 |
GO:00988767 | Cervix | CC | vesicle-mediated transport to the plasma membrane | 34/2311 | 136/18723 | 3.75e-05 | 5.91e-04 | 34 |
GO:00161977 | Cervix | CC | endosomal transport | 48/2311 | 230/18723 | 1.65e-04 | 1.97e-03 | 48 |
GO:00481938 | Cervix | CC | Golgi vesicle transport | 58/2311 | 296/18723 | 2.24e-04 | 2.54e-03 | 58 |
GO:00068907 | Cervix | CC | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 15/2311 | 52/18723 | 1.15e-03 | 9.39e-03 | 15 |
GO:00171574 | Cervix | CC | regulation of exocytosis | 39/2311 | 202/18723 | 2.90e-03 | 1.93e-02 | 39 |
GO:00164827 | Cervix | CC | cytosolic transport | 33/2311 | 168/18723 | 4.43e-03 | 2.70e-02 | 33 |
GO:19901827 | Cervix | CC | exosomal secretion | 7/2311 | 20/18723 | 7.78e-03 | 4.10e-02 | 7 |
GO:00068873 | Cervix | CC | exocytosis | 59/2311 | 352/18723 | 8.74e-03 | 4.48e-02 | 59 |
GO:00977347 | Cervix | CC | extracellular exosome biogenesis | 7/2311 | 21/18723 | 1.04e-02 | 4.97e-02 | 7 |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:0016482 | Colorectum | AD | cytosolic transport | 68/3918 | 168/18723 | 6.00e-09 | 3.72e-07 | 68 |
GO:0098876 | Colorectum | AD | vesicle-mediated transport to the plasma membrane | 57/3918 | 136/18723 | 2.30e-08 | 1.27e-06 | 57 |
GO:1990182 | Colorectum | AD | exosomal secretion | 16/3918 | 20/18723 | 2.67e-08 | 1.47e-06 | 16 |
GO:0097734 | Colorectum | AD | extracellular exosome biogenesis | 16/3918 | 21/18723 | 9.02e-08 | 4.52e-06 | 16 |
GO:0032386 | Colorectum | AD | regulation of intracellular transport | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0140112 | Colorectum | AD | extracellular vesicle biogenesis | 16/3918 | 23/18723 | 7.04e-07 | 2.49e-05 | 16 |
GO:0006890 | Colorectum | AD | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 27/3918 | 52/18723 | 7.67e-07 | 2.70e-05 | 27 |
GO:1903541 | Colorectum | AD | regulation of exosomal secretion | 13/3918 | 17/18723 | 1.46e-06 | 4.58e-05 | 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP9A | SNV | Missense_Mutation | rs752675481 | c.880N>A | p.Gly294Ser | p.G294S | O75110 | protein_coding | deleterious(0.02) | possibly_damaging(0.654) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ATP9A | SNV | Missense_Mutation | c.77N>T | p.Glu26Val | p.E26V | O75110 | protein_coding | tolerated(0.21) | benign(0.017) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATP9A | SNV | Missense_Mutation | novel | c.1101N>C | p.Lys367Asn | p.K367N | O75110 | protein_coding | tolerated(0.5) | benign(0.006) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATP9A | SNV | Missense_Mutation | rs756569236 | c.2665G>A | p.Val889Met | p.V889M | O75110 | protein_coding | deleterious(0) | possibly_damaging(0.696) | TCGA-AZ-6607-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ATP9A | SNV | Missense_Mutation | novel | c.1900N>G | p.Thr634Ala | p.T634A | O75110 | protein_coding | tolerated(1) | benign(0.001) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ATP9A | SNV | Missense_Mutation | c.1462T>C | p.Tyr488His | p.Y488H | O75110 | protein_coding | tolerated(0.36) | possibly_damaging(0.489) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATP9A | SNV | Missense_Mutation | c.3101G>A | p.Arg1034Gln | p.R1034Q | O75110 | protein_coding | tolerated(0.1) | benign(0.217) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ATP9A | SNV | Missense_Mutation | rs761097614 | c.869G>A | p.Arg290Gln | p.R290Q | O75110 | protein_coding | deleterious(0.04) | benign(0.386) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATP9A | SNV | Missense_Mutation | c.2095G>T | p.Asp699Tyr | p.D699Y | O75110 | protein_coding | tolerated(1) | possibly_damaging(0.82) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ATP9A | deletion | Frame_Shift_Del | c.1291delN | p.Gln431SerfsTer22 | p.Q431Sfs*22 | O75110 | protein_coding | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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