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Gene: ATP5A1 |
Gene summary for ATP5A1 |
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Gene information | Species | Human | Gene symbol | ATP5A1 | Gene ID | 498 |
Gene name | ATP synthase F1 subunit alpha | |
Gene Alias | ATP5A | |
Cytomap | 18q21.1 | |
Gene Type | protein-coding | GO ID | GO:0001667 | UniProtAcc | P25705 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
498 | ATP5A1 | GSM4909281 | Human | Breast | IDC | 1.23e-14 | -3.15e-01 | 0.21 |
498 | ATP5A1 | GSM4909282 | Human | Breast | IDC | 2.75e-14 | -3.15e-01 | -0.0288 |
498 | ATP5A1 | GSM4909285 | Human | Breast | IDC | 5.48e-15 | -3.15e-01 | 0.21 |
498 | ATP5A1 | GSM4909286 | Human | Breast | IDC | 2.75e-14 | -3.15e-01 | 0.1081 |
498 | ATP5A1 | GSM4909287 | Human | Breast | IDC | 2.45e-14 | -3.15e-01 | 0.2057 |
498 | ATP5A1 | GSM4909288 | Human | Breast | IDC | 1.62e-02 | -3.15e-01 | 0.0988 |
498 | ATP5A1 | GSM4909290 | Human | Breast | IDC | 5.89e-10 | -3.15e-01 | 0.2096 |
498 | ATP5A1 | GSM4909291 | Human | Breast | IDC | 7.33e-08 | -3.15e-01 | 0.1753 |
498 | ATP5A1 | GSM4909293 | Human | Breast | IDC | 2.75e-14 | -3.15e-01 | 0.1581 |
498 | ATP5A1 | GSM4909294 | Human | Breast | IDC | 4.80e-16 | -3.15e-01 | 0.2022 |
498 | ATP5A1 | GSM4909295 | Human | Breast | IDC | 6.08e-06 | -3.15e-01 | 0.0898 |
498 | ATP5A1 | GSM4909296 | Human | Breast | IDC | 5.48e-15 | -3.15e-01 | 0.1524 |
498 | ATP5A1 | GSM4909297 | Human | Breast | IDC | 4.12e-17 | -3.15e-01 | 0.1517 |
498 | ATP5A1 | GSM4909298 | Human | Breast | IDC | 1.08e-15 | -3.15e-01 | 0.1551 |
498 | ATP5A1 | GSM4909299 | Human | Breast | IDC | 6.13e-14 | -3.15e-01 | 0.035 |
498 | ATP5A1 | GSM4909300 | Human | Breast | IDC | 4.08e-05 | -3.15e-01 | 0.0334 |
498 | ATP5A1 | GSM4909301 | Human | Breast | IDC | 4.80e-16 | -3.15e-01 | 0.1577 |
498 | ATP5A1 | GSM4909302 | Human | Breast | IDC | 4.08e-14 | -3.15e-01 | 0.1545 |
498 | ATP5A1 | GSM4909303 | Human | Breast | IDC | 5.11e-03 | -3.15e-01 | 0.0438 |
498 | ATP5A1 | GSM4909304 | Human | Breast | IDC | 4.80e-16 | -3.15e-01 | 0.1636 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP5A1 | SNV | Missense_Mutation | c.800N>T | p.Asp267Val | p.D267V | P25705 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.679) | TCGA-G3-A5SJ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ATP5A1 | SNV | Missense_Mutation | c.254N>T | p.His85Leu | p.H85L | P25705 | protein_coding | deleterious_low_confidence(0.01) | benign(0.198) | TCGA-55-6969-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ATP5A1 | SNV | Missense_Mutation | c.635N>C | p.Gly212Ala | p.G212A | P25705 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.96) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATP5A1 | SNV | Missense_Mutation | novel | c.1504N>G | p.Ser502Gly | p.S502G | P25705 | protein_coding | tolerated_low_confidence(0.18) | benign(0.003) | TCGA-21-A5DI-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ATP5A1 | SNV | Missense_Mutation | rs367927966 | c.676N>G | p.Ile226Val | p.I226V | P25705 | protein_coding | deleterious_low_confidence(0.01) | benign(0.442) | TCGA-22-5481-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ATP5A1 | SNV | Missense_Mutation | c.1144N>G | p.Pro382Ala | p.P382A | P25705 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-39-5031-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATP5A1 | SNV | Missense_Mutation | novel | c.121N>T | p.Thr41Ser | p.T41S | P25705 | protein_coding | tolerated_low_confidence(0.45) | benign(0) | TCGA-60-2696-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP5A1 | SNV | Missense_Mutation | c.1556A>T | p.His519Leu | p.H519L | P25705 | protein_coding | tolerated_low_confidence(0.07) | benign(0.14) | TCGA-66-2787-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ATP5A1 | deletion | In_Frame_Del | novel | c.778_780delNNN | p.Val260del | p.V260del | P25705 | protein_coding | TCGA-91-6836-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ATP5A1 | SNV | Missense_Mutation | novel | c.1578N>G | p.Ile526Met | p.I526M | P25705 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.989) | TCGA-UF-A71E-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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