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Gene: ATP2C2 |
Gene summary for ATP2C2 |
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Gene information | Species | Human | Gene symbol | ATP2C2 | Gene ID | 9914 |
Gene name | ATPase secretory pathway Ca2+ transporting 2 | |
Gene Alias | SPCA2 | |
Cytomap | 16q24.1 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | A0A0A0MSP0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9914 | ATP2C2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.61e-10 | -4.29e-01 | 0.0155 |
9914 | ATP2C2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.32e-07 | -8.16e-01 | 0.0216 |
9914 | ATP2C2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.68e-28 | 1.23e+00 | -0.1954 |
9914 | ATP2C2 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.35e-07 | 9.96e-01 | -0.2602 |
9914 | ATP2C2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.76e-14 | 7.85e-01 | -0.2196 |
9914 | ATP2C2 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.29e-14 | 9.70e-01 | -0.1464 |
9914 | ATP2C2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.56e-09 | 6.27e-01 | -0.1706 |
9914 | ATP2C2 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.97e-06 | 7.46e-01 | -0.0842 |
9914 | ATP2C2 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.50e-06 | -4.72e-01 | 0.096 |
9914 | ATP2C2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.28e-03 | 4.36e-01 | 0.0131 |
9914 | ATP2C2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.09e-06 | -5.74e-01 | 0.0338 |
9914 | ATP2C2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.51e-08 | 7.77e-01 | 0.0112 |
9914 | ATP2C2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.11e-32 | -6.96e-01 | 0.294 |
9914 | ATP2C2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.97e-11 | 8.42e-01 | 0.281 |
9914 | ATP2C2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.05e-13 | -8.59e-01 | 0.2585 |
9914 | ATP2C2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.33e-06 | -4.39e-01 | 0.3005 |
9914 | ATP2C2 | F007 | Human | Colorectum | FAP | 9.17e-17 | -7.61e-01 | 0.1176 |
9914 | ATP2C2 | A002-C-010 | Human | Colorectum | FAP | 8.34e-10 | -4.46e-01 | 0.242 |
9914 | ATP2C2 | A001-C-207 | Human | Colorectum | FAP | 7.31e-26 | -8.45e-01 | 0.1278 |
9914 | ATP2C2 | A015-C-203 | Human | Colorectum | FAP | 1.33e-60 | -1.00e+00 | -0.1294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0030879 | Colorectum | AD | mammary gland development | 53/3918 | 137/18723 | 1.46e-06 | 4.58e-05 | 53 |
GO:0061180 | Colorectum | AD | mammary gland epithelium development | 28/3918 | 67/18723 | 8.74e-05 | 1.35e-03 | 28 |
GO:0071421 | Colorectum | AD | manganese ion transmembrane transport | 6/3918 | 10/18723 | 8.03e-03 | 4.73e-02 | 6 |
GO:00726591 | Colorectum | SER | protein localization to plasma membrane | 92/2897 | 284/18723 | 6.36e-13 | 1.86e-10 | 92 |
GO:19907781 | Colorectum | SER | protein localization to cell periphery | 98/2897 | 333/18723 | 6.09e-11 | 9.57e-09 | 98 |
GO:00487321 | Colorectum | SER | gland development | 112/2897 | 436/18723 | 1.75e-08 | 1.28e-06 | 112 |
GO:00611801 | Colorectum | SER | mammary gland epithelium development | 22/2897 | 67/18723 | 3.11e-04 | 5.03e-03 | 22 |
GO:00308791 | Colorectum | SER | mammary gland development | 37/2897 | 137/18723 | 3.61e-04 | 5.61e-03 | 37 |
GO:00726592 | Colorectum | MSS | protein localization to plasma membrane | 113/3467 | 284/18723 | 3.23e-17 | 1.55e-14 | 113 |
GO:19907782 | Colorectum | MSS | protein localization to cell periphery | 120/3467 | 333/18723 | 2.02e-14 | 5.47e-12 | 120 |
GO:00487322 | Colorectum | MSS | gland development | 143/3467 | 436/18723 | 3.85e-13 | 8.01e-11 | 143 |
GO:00308792 | Colorectum | MSS | mammary gland development | 51/3467 | 137/18723 | 1.88e-07 | 8.26e-06 | 51 |
GO:00611802 | Colorectum | MSS | mammary gland epithelium development | 28/3467 | 67/18723 | 8.47e-06 | 2.11e-04 | 28 |
GO:00726594 | Colorectum | FAP | protein localization to plasma membrane | 95/2622 | 284/18723 | 4.86e-17 | 9.93e-14 | 95 |
GO:19907784 | Colorectum | FAP | protein localization to cell periphery | 100/2622 | 333/18723 | 2.19e-14 | 2.68e-11 | 100 |
GO:00487324 | Colorectum | FAP | gland development | 103/2622 | 436/18723 | 3.61e-08 | 3.12e-06 | 103 |
GO:0010959 | Colorectum | FAP | regulation of metal ion transport | 83/2622 | 406/18723 | 2.06e-04 | 2.96e-03 | 83 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP2C2 | SNV | Missense_Mutation | c.2473N>A | p.Val825Met | p.V825M | protein_coding | tolerated(0.25) | benign(0.037) | TCGA-AG-3909-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR | ||
ATP2C2 | SNV | Missense_Mutation | c.2161G>A | p.Glu721Lys | p.E721K | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F5-6810-01 | Colorectum | rectum adenocarcinoma | Unknown | Unknown | I/II | Unknown | Unknown | Unknown | ||
ATP2C2 | deletion | Frame_Shift_Del | c.2174delN | p.Tyr727ThrfsTer11 | p.Y727Tfs*11 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||||
ATP2C2 | deletion | In_Frame_Del | c.2639_2641delNNN | p.Phe881del | p.F881del | protein_coding | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | ||||
ATP2C2 | deletion | Frame_Shift_Del | c.2179delT | p.Tyr727ThrfsTer11 | p.Y727Tfs*11 | protein_coding | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||||
ATP2C2 | SNV | Missense_Mutation | novel | c.473N>T | p.Ser158Phe | p.S158F | protein_coding | deleterious(0) | possibly_damaging(0.747) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ATP2C2 | SNV | Missense_Mutation | rs370258691 | c.1334N>T | p.Ala445Val | p.A445V | protein_coding | deleterious(0) | possibly_damaging(0.84) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ATP2C2 | SNV | Missense_Mutation | c.253N>T | p.Arg85Cys | p.R85C | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ATP2C2 | SNV | Missense_Mutation | novel | c.874N>A | p.Asp292Asn | p.D292N | protein_coding | deleterious(0.03) | possibly_damaging(0.875) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ATP2C2 | SNV | Missense_Mutation | rs765718239 | c.1037N>T | p.Thr346Met | p.T346M | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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