![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ARMC10 |
Gene summary for ARMC10 |
![]() |
Gene information | Species | Human | Gene symbol | ARMC10 | Gene ID | 83787 |
Gene name | armadillo repeat containing 10 | |
Gene Alias | PNAS-112 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | Q8N2F6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83787 | ARMC10 | LZE20T | Human | Esophagus | ESCC | 2.12e-09 | 5.28e-01 | 0.0662 |
83787 | ARMC10 | LZE22T | Human | Esophagus | ESCC | 1.33e-03 | 5.92e-01 | 0.068 |
83787 | ARMC10 | LZE24T | Human | Esophagus | ESCC | 3.38e-18 | 7.15e-01 | 0.0596 |
83787 | ARMC10 | LZE21T | Human | Esophagus | ESCC | 5.18e-04 | 3.68e-01 | 0.0655 |
83787 | ARMC10 | P1T-E | Human | Esophagus | ESCC | 4.10e-10 | 7.56e-01 | 0.0875 |
83787 | ARMC10 | P2T-E | Human | Esophagus | ESCC | 9.88e-117 | 1.87e+00 | 0.1177 |
83787 | ARMC10 | P4T-E | Human | Esophagus | ESCC | 3.31e-60 | 1.50e+00 | 0.1323 |
83787 | ARMC10 | P5T-E | Human | Esophagus | ESCC | 3.02e-61 | 1.18e+00 | 0.1327 |
83787 | ARMC10 | P8T-E | Human | Esophagus | ESCC | 4.56e-36 | 6.16e-01 | 0.0889 |
83787 | ARMC10 | P9T-E | Human | Esophagus | ESCC | 1.08e-33 | 8.96e-01 | 0.1131 |
83787 | ARMC10 | P10T-E | Human | Esophagus | ESCC | 5.96e-69 | 1.08e+00 | 0.116 |
83787 | ARMC10 | P11T-E | Human | Esophagus | ESCC | 4.65e-25 | 1.04e+00 | 0.1426 |
83787 | ARMC10 | P12T-E | Human | Esophagus | ESCC | 2.69e-68 | 1.17e+00 | 0.1122 |
83787 | ARMC10 | P15T-E | Human | Esophagus | ESCC | 1.02e-80 | 1.71e+00 | 0.1149 |
83787 | ARMC10 | P16T-E | Human | Esophagus | ESCC | 9.01e-91 | 1.49e+00 | 0.1153 |
83787 | ARMC10 | P17T-E | Human | Esophagus | ESCC | 3.16e-25 | 1.27e+00 | 0.1278 |
83787 | ARMC10 | P19T-E | Human | Esophagus | ESCC | 4.74e-20 | 1.44e+00 | 0.1662 |
83787 | ARMC10 | P20T-E | Human | Esophagus | ESCC | 1.02e-68 | 1.58e+00 | 0.1124 |
83787 | ARMC10 | P21T-E | Human | Esophagus | ESCC | 3.17e-88 | 1.77e+00 | 0.1617 |
83787 | ARMC10 | P22T-E | Human | Esophagus | ESCC | 2.39e-60 | 8.50e-01 | 0.1236 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097193111 | Esophagus | ESCC | intrinsic apoptotic signaling pathway | 222/8552 | 288/18723 | 5.87e-28 | 2.02e-25 | 222 |
GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
GO:2001242111 | Esophagus | ESCC | regulation of intrinsic apoptotic signaling pathway | 128/8552 | 164/18723 | 1.75e-17 | 1.50e-15 | 128 |
GO:2001234111 | Esophagus | ESCC | negative regulation of apoptotic signaling pathway | 161/8552 | 224/18723 | 1.24e-15 | 8.09e-14 | 161 |
GO:0072331111 | Esophagus | ESCC | signal transduction by p53 class mediator | 121/8552 | 163/18723 | 9.61e-14 | 4.69e-12 | 121 |
GO:2001243111 | Esophagus | ESCC | negative regulation of intrinsic apoptotic signaling pathway | 78/8552 | 98/18723 | 5.50e-12 | 2.10e-10 | 78 |
GO:1901796111 | Esophagus | ESCC | regulation of signal transduction by p53 class mediator | 70/8552 | 93/18723 | 5.69e-09 | 1.18e-07 | 70 |
GO:0072332111 | Esophagus | ESCC | intrinsic apoptotic signaling pathway by p53 class mediator | 59/8552 | 76/18723 | 1.22e-08 | 2.42e-07 | 59 |
GO:1902253110 | Esophagus | ESCC | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 23/8552 | 29/18723 | 2.25e-04 | 1.40e-03 | 23 |
GO:19017975 | Esophagus | ESCC | negative regulation of signal transduction by p53 class mediator | 22/8552 | 31/18723 | 3.90e-03 | 1.58e-02 | 22 |
GO:19022544 | Esophagus | ESCC | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 16/8552 | 21/18723 | 4.47e-03 | 1.76e-02 | 16 |
GO:200123312 | Liver | Cirrhotic | regulation of apoptotic signaling pathway | 163/4634 | 356/18723 | 2.62e-18 | 4.43e-16 | 163 |
GO:009719312 | Liver | Cirrhotic | intrinsic apoptotic signaling pathway | 130/4634 | 288/18723 | 2.69e-14 | 2.45e-12 | 130 |
GO:20012427 | Liver | Cirrhotic | regulation of intrinsic apoptotic signaling pathway | 82/4634 | 164/18723 | 2.35e-12 | 1.71e-10 | 82 |
GO:20012347 | Liver | Cirrhotic | negative regulation of apoptotic signaling pathway | 102/4634 | 224/18723 | 8.40e-12 | 5.60e-10 | 102 |
GO:20012437 | Liver | Cirrhotic | negative regulation of intrinsic apoptotic signaling pathway | 47/4634 | 98/18723 | 5.26e-07 | 1.17e-05 | 47 |
GO:007233112 | Liver | Cirrhotic | signal transduction by p53 class mediator | 69/4634 | 163/18723 | 5.97e-07 | 1.30e-05 | 69 |
GO:00723326 | Liver | Cirrhotic | intrinsic apoptotic signaling pathway by p53 class mediator | 38/4634 | 76/18723 | 1.75e-06 | 3.32e-05 | 38 |
GO:190179612 | Liver | Cirrhotic | regulation of signal transduction by p53 class mediator | 37/4634 | 93/18723 | 9.58e-04 | 6.78e-03 | 37 |
GO:19022535 | Liver | Cirrhotic | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 14/4634 | 29/18723 | 5.09e-03 | 2.62e-02 | 14 |
Page: 1 2 3 4 5 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARMC10 | SNV | Missense_Mutation | novel | c.446A>T | p.His149Leu | p.H149L | Q8N2F6 | protein_coding | deleterious(0.01) | benign(0.079) | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
ARMC10 | insertion | Frame_Shift_Ins | novel | c.444_445insGG | p.His149GlyfsTer12 | p.H149Gfs*12 | Q8N2F6 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |