|
Gene: ARHGAP5 |
Gene summary for ARHGAP5 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ARHGAP5 | Gene ID | 394 |
Gene name | Rho GTPase activating protein 5 | |
Gene Alias | GFI2 | |
Cytomap | 14q12 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q13017 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
394 | ARHGAP5 | CA_HPV_1 | Human | Cervix | CC | 1.72e-05 | -2.16e-01 | 0.0264 |
394 | ARHGAP5 | CA_HPV_3 | Human | Cervix | CC | 9.88e-04 | 1.61e-01 | 0.0414 |
394 | ARHGAP5 | CCI_1 | Human | Cervix | CC | 3.93e-03 | 6.64e-01 | 0.528 |
394 | ARHGAP5 | CCI_2 | Human | Cervix | CC | 3.54e-13 | 1.37e+00 | 0.5249 |
394 | ARHGAP5 | CCI_3 | Human | Cervix | CC | 5.24e-03 | 7.03e-01 | 0.516 |
394 | ARHGAP5 | T3 | Human | Cervix | CC | 5.79e-03 | 1.76e-01 | 0.1389 |
394 | ARHGAP5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.45e-31 | -8.38e-01 | 0.0155 |
394 | ARHGAP5 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.66e-08 | -5.64e-01 | -0.1808 |
394 | ARHGAP5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.52e-05 | -4.80e-01 | -0.0811 |
394 | ARHGAP5 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.18e-07 | -6.67e-01 | -0.1207 |
394 | ARHGAP5 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.47e-05 | -5.90e-01 | -0.1526 |
394 | ARHGAP5 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.09e-14 | -5.56e-01 | -0.1464 |
394 | ARHGAP5 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.88e-11 | -5.15e-01 | -0.1001 |
394 | ARHGAP5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.29e-02 | -4.34e-01 | -0.059 |
394 | ARHGAP5 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.06e-03 | -6.96e-01 | -0.2061 |
394 | ARHGAP5 | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.75e-05 | -7.27e-01 | -0.0179 |
394 | ARHGAP5 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.19e-14 | -6.47e-01 | 0.096 |
394 | ARHGAP5 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.50e-02 | -6.61e-01 | 0.0446 |
394 | ARHGAP5 | HTA11_8622_2000001021 | Human | Colorectum | SER | 9.46e-05 | -7.71e-01 | 0.0528 |
394 | ARHGAP5 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.82e-06 | -5.45e-01 | 0.0338 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:00072656 | Cervix | CC | Ras protein signal transduction | 79/2311 | 337/18723 | 9.49e-09 | 7.77e-07 | 79 |
GO:00072666 | Cervix | CC | Rho protein signal transduction | 35/2311 | 137/18723 | 1.77e-05 | 3.33e-04 | 35 |
GO:004873210 | Cervix | CC | gland development | 84/2311 | 436/18723 | 1.93e-05 | 3.54e-04 | 84 |
GO:00308797 | Cervix | CC | mammary gland development | 28/2311 | 137/18723 | 4.74e-03 | 2.83e-02 | 28 |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0030879 | Colorectum | AD | mammary gland development | 53/3918 | 137/18723 | 1.46e-06 | 4.58e-05 | 53 |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:0007266 | Colorectum | AD | Rho protein signal transduction | 42/3918 | 137/18723 | 4.64e-03 | 3.16e-02 | 42 |
GO:00487321 | Colorectum | SER | gland development | 112/2897 | 436/18723 | 1.75e-08 | 1.28e-06 | 112 |
GO:00308791 | Colorectum | SER | mammary gland development | 37/2897 | 137/18723 | 3.61e-04 | 5.61e-03 | 37 |
GO:00487322 | Colorectum | MSS | gland development | 143/3467 | 436/18723 | 3.85e-13 | 8.01e-11 | 143 |
GO:00308792 | Colorectum | MSS | mammary gland development | 51/3467 | 137/18723 | 1.88e-07 | 8.26e-06 | 51 |
GO:00072651 | Colorectum | MSS | Ras protein signal transduction | 91/3467 | 337/18723 | 7.20e-05 | 1.21e-03 | 91 |
GO:00510561 | Colorectum | MSS | regulation of small GTPase mediated signal transduction | 82/3467 | 302/18723 | 1.31e-04 | 1.99e-03 | 82 |
GO:00510562 | Colorectum | FAP | regulation of small GTPase mediated signal transduction | 78/2622 | 302/18723 | 3.25e-08 | 2.85e-06 | 78 |
GO:00487324 | Colorectum | FAP | gland development | 103/2622 | 436/18723 | 3.61e-08 | 3.12e-06 | 103 |
GO:00072652 | Colorectum | FAP | Ras protein signal transduction | 80/2622 | 337/18723 | 9.61e-07 | 4.33e-05 | 80 |
GO:00072661 | Colorectum | FAP | Rho protein signal transduction | 34/2622 | 137/18723 | 5.11e-04 | 5.82e-03 | 34 |
Page: 1 2 3 4 5 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0451010 | Cervix | CC | Focal adhesion | 59/1267 | 203/8465 | 1.53e-07 | 1.84e-06 | 1.09e-06 | 59 |
hsa0467020 | Cervix | CC | Leukocyte transendothelial migration | 36/1267 | 114/8465 | 5.22e-06 | 4.83e-05 | 2.86e-05 | 36 |
hsa0451014 | Cervix | CC | Focal adhesion | 59/1267 | 203/8465 | 1.53e-07 | 1.84e-06 | 1.09e-06 | 59 |
hsa04670110 | Cervix | CC | Leukocyte transendothelial migration | 36/1267 | 114/8465 | 5.22e-06 | 4.83e-05 | 2.86e-05 | 36 |
hsa04510 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa04670 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa045101 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa046701 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa046702 | Colorectum | SER | Leukocyte transendothelial migration | 37/1580 | 114/8465 | 2.77e-04 | 2.56e-03 | 1.86e-03 | 37 |
hsa046703 | Colorectum | SER | Leukocyte transendothelial migration | 37/1580 | 114/8465 | 2.77e-04 | 2.56e-03 | 1.86e-03 | 37 |
hsa046704 | Colorectum | MSS | Leukocyte transendothelial migration | 36/1875 | 114/8465 | 1.21e-02 | 4.02e-02 | 2.46e-02 | 36 |
hsa046705 | Colorectum | MSS | Leukocyte transendothelial migration | 36/1875 | 114/8465 | 1.21e-02 | 4.02e-02 | 2.46e-02 | 36 |
hsa045102 | Colorectum | FAP | Focal adhesion | 61/1404 | 203/8465 | 1.03e-06 | 2.15e-05 | 1.31e-05 | 61 |
hsa046706 | Colorectum | FAP | Leukocyte transendothelial migration | 37/1404 | 114/8465 | 2.12e-05 | 2.53e-04 | 1.54e-04 | 37 |
hsa045103 | Colorectum | FAP | Focal adhesion | 61/1404 | 203/8465 | 1.03e-06 | 2.15e-05 | 1.31e-05 | 61 |
hsa046707 | Colorectum | FAP | Leukocyte transendothelial migration | 37/1404 | 114/8465 | 2.12e-05 | 2.53e-04 | 1.54e-04 | 37 |
hsa045104 | Colorectum | CRC | Focal adhesion | 51/1091 | 203/8465 | 1.29e-06 | 5.41e-05 | 3.66e-05 | 51 |
hsa046708 | Colorectum | CRC | Leukocyte transendothelial migration | 25/1091 | 114/8465 | 4.82e-03 | 2.66e-02 | 1.80e-02 | 25 |
hsa045105 | Colorectum | CRC | Focal adhesion | 51/1091 | 203/8465 | 1.29e-06 | 5.41e-05 | 3.66e-05 | 51 |
hsa046709 | Colorectum | CRC | Leukocyte transendothelial migration | 25/1091 | 114/8465 | 4.82e-03 | 2.66e-02 | 1.80e-02 | 25 |
Page: 1 2 3 4 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGAP5 | SNV | Missense_Mutation | c.4393N>T | p.Pro1465Ser | p.P1465S | Q13017 | protein_coding | tolerated_low_confidence(0.52) | possibly_damaging(0.727) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARHGAP5 | SNV | Missense_Mutation | novel | c.7G>A | p.Ala3Thr | p.A3T | Q13017 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ARHGAP5 | SNV | Missense_Mutation | novel | c.2826A>C | p.Lys942Asn | p.K942N | Q13017 | protein_coding | deleterious(0) | probably_damaging(0.937) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ARHGAP5 | SNV | Missense_Mutation | novel | c.3689A>C | p.Lys1230Thr | p.K1230T | Q13017 | protein_coding | tolerated(0.4) | probably_damaging(0.991) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ARHGAP5 | SNV | Missense_Mutation | novel | c.3735G>T | p.Lys1245Asn | p.K1245N | Q13017 | protein_coding | deleterious(0.02) | probably_damaging(0.945) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ARHGAP5 | SNV | Missense_Mutation | c.1614N>T | p.Arg538Ser | p.R538S | Q13017 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ARHGAP5 | SNV | Missense_Mutation | rs760626630 | c.2576G>A | p.Arg859Gln | p.R859Q | Q13017 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARHGAP5 | SNV | Missense_Mutation | c.713N>A | p.Cys238Tyr | p.C238Y | Q13017 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ARHGAP5 | SNV | Missense_Mutation | c.2669A>T | p.Asp890Val | p.D890V | Q13017 | protein_coding | deleterious(0.01) | probably_damaging(0.916) | TCGA-AG-3887-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | irinotecan | SD | |
ARHGAP5 | SNV | Missense_Mutation | rs779050241 | c.3351N>G | p.Asn1117Lys | p.N1117K | Q13017 | protein_coding | tolerated(0.12) | benign(0.101) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |