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Gene: AQP8 |
Gene summary for AQP8 |
Gene summary. |
Gene information | Species | Human | Gene symbol | AQP8 | Gene ID | 343 |
Gene name | aquaporin 8 | |
Gene Alias | AQP-8 | |
Cytomap | 16p12.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | O94778 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
343 | AQP8 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.99e-05 | 1.07e+00 | -0.1808 |
343 | AQP8 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.66e-05 | 8.99e-01 | -0.1954 |
343 | AQP8 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.74e-13 | 1.54e+00 | -0.1207 |
343 | AQP8 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.16e-08 | 1.80e+00 | -0.2061 |
343 | AQP8 | A008-E-015 | Human | Colorectum | FAP | 1.48e-20 | 5.65e-01 | 0.0177 |
343 | AQP8 | HTA12-29-1 | Human | Pancreas | PDAC | 1.49e-09 | -5.10e-01 | 0.3722 |
343 | AQP8 | HTA12-9-1 | Human | Pancreas | PDAC | 2.56e-03 | -5.10e-01 | 0.1532 |
343 | AQP8 | 3829-EC | Human | Pancreas | PanIN | 6.87e-05 | -2.73e-01 | 0.009 |
343 | AQP8 | 4347-EC | Human | Pancreas | PanIN | 2.39e-12 | -3.91e-01 | 0.0572 |
343 | AQP8 | DS20191261Tumor | Human | Pancreas | PDAC | 1.56e-04 | -5.10e-01 | 0.1367 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051591 | Colorectum | AD | response to cAMP | 31/3918 | 93/18723 | 3.59e-03 | 2.58e-02 | 31 |
GO:0071320 | Colorectum | AD | cellular response to cAMP | 20/3918 | 53/18723 | 3.71e-03 | 2.62e-02 | 20 |
GO:00713201 | Colorectum | SER | cellular response to cAMP | 16/2897 | 53/18723 | 5.09e-03 | 3.91e-02 | 16 |
GO:00515911 | Colorectum | FAP | response to cAMP | 27/2622 | 93/18723 | 1.26e-04 | 2.03e-03 | 27 |
GO:0046683 | Colorectum | FAP | response to organophosphorus | 33/2622 | 131/18723 | 4.61e-04 | 5.39e-03 | 33 |
GO:00713202 | Colorectum | FAP | cellular response to cAMP | 17/2622 | 53/18723 | 6.20e-04 | 6.82e-03 | 17 |
GO:0014074 | Colorectum | FAP | response to purine-containing compound | 35/2622 | 148/18723 | 1.09e-03 | 1.05e-02 | 35 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04976 | Colorectum | FAP | Bile secretion | 24/1404 | 89/8465 | 8.76e-03 | 3.21e-02 | 1.96e-02 | 24 |
hsa049761 | Colorectum | FAP | Bile secretion | 24/1404 | 89/8465 | 8.76e-03 | 3.21e-02 | 1.96e-02 | 24 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AQP8 | SNV | Missense_Mutation | rs139054676 | c.370N>A | p.Gly124Arg | p.G124R | O94778 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-HU-A4GC-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
AQP8 | SNV | Missense_Mutation | novel | c.263N>C | p.Gly88Ala | p.G88A | O94778 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-VQ-A92D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
343 | AQP8 | ION CHANNEL | inhibitor | 178101032 | ||
343 | AQP8 | ION CHANNEL | ETHINYLESTRADIOL | ETHINYL ESTRADIOL | 18683753 |
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