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Gene: ANKMY2 |
Gene summary for ANKMY2 |
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Gene information | Species | Human | Gene symbol | ANKMY2 | Gene ID | 57037 |
Gene name | ankyrin repeat and MYND domain containing 2 | |
Gene Alias | ZMYND20 | |
Cytomap | 7p21.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R9Z6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57037 | ANKMY2 | LZE4T | Human | Esophagus | ESCC | 2.39e-07 | 2.17e-01 | 0.0811 |
57037 | ANKMY2 | LZE24T | Human | Esophagus | ESCC | 4.15e-07 | 2.28e-01 | 0.0596 |
57037 | ANKMY2 | P2T-E | Human | Esophagus | ESCC | 2.42e-15 | 2.39e-01 | 0.1177 |
57037 | ANKMY2 | P4T-E | Human | Esophagus | ESCC | 1.56e-11 | 2.23e-01 | 0.1323 |
57037 | ANKMY2 | P5T-E | Human | Esophagus | ESCC | 1.12e-02 | 6.29e-02 | 0.1327 |
57037 | ANKMY2 | P8T-E | Human | Esophagus | ESCC | 2.06e-07 | 2.15e-01 | 0.0889 |
57037 | ANKMY2 | P9T-E | Human | Esophagus | ESCC | 8.05e-03 | 1.25e-01 | 0.1131 |
57037 | ANKMY2 | P10T-E | Human | Esophagus | ESCC | 1.53e-19 | 3.02e-01 | 0.116 |
57037 | ANKMY2 | P11T-E | Human | Esophagus | ESCC | 2.59e-07 | 2.78e-01 | 0.1426 |
57037 | ANKMY2 | P12T-E | Human | Esophagus | ESCC | 1.77e-22 | 3.40e-01 | 0.1122 |
57037 | ANKMY2 | P15T-E | Human | Esophagus | ESCC | 8.40e-07 | 2.14e-01 | 0.1149 |
57037 | ANKMY2 | P16T-E | Human | Esophagus | ESCC | 1.29e-13 | 3.15e-01 | 0.1153 |
57037 | ANKMY2 | P20T-E | Human | Esophagus | ESCC | 2.64e-13 | 3.08e-01 | 0.1124 |
57037 | ANKMY2 | P21T-E | Human | Esophagus | ESCC | 2.85e-14 | 1.58e-01 | 0.1617 |
57037 | ANKMY2 | P22T-E | Human | Esophagus | ESCC | 2.56e-10 | 1.62e-01 | 0.1236 |
57037 | ANKMY2 | P23T-E | Human | Esophagus | ESCC | 1.97e-11 | 2.19e-01 | 0.108 |
57037 | ANKMY2 | P24T-E | Human | Esophagus | ESCC | 9.16e-05 | 6.18e-02 | 0.1287 |
57037 | ANKMY2 | P26T-E | Human | Esophagus | ESCC | 5.78e-14 | 2.80e-01 | 0.1276 |
57037 | ANKMY2 | P27T-E | Human | Esophagus | ESCC | 4.44e-19 | 2.51e-01 | 0.1055 |
57037 | ANKMY2 | P28T-E | Human | Esophagus | ESCC | 3.99e-04 | 1.35e-01 | 0.1149 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKMY2 | SNV | Missense_Mutation | c.971N>T | p.Gly324Val | p.G324V | Q8IV38 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-18-3406-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ANKMY2 | SNV | Missense_Mutation | novel | c.721N>T | p.Asn241Tyr | p.N241Y | Q8IV38 | protein_coding | deleterious(0) | benign(0.423) | TCGA-22-A5C4-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ANKMY2 | SNV | Missense_Mutation | novel | c.645T>A | p.Asn215Lys | p.N215K | Q8IV38 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-34-8454-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ANKMY2 | SNV | Missense_Mutation | c.1098N>T | p.Lys366Asn | p.K366N | Q8IV38 | protein_coding | deleterious(0.01) | benign(0.15) | TCGA-37-5819-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
ANKMY2 | SNV | Missense_Mutation | rs750492927 | c.1237N>A | p.Gly413Arg | p.G413R | Q8IV38 | protein_coding | tolerated_low_confidence(0.54) | benign(0.003) | TCGA-56-A4ZJ-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKMY2 | SNV | Missense_Mutation | novel | c.540N>C | p.Met180Ile | p.M180I | Q8IV38 | protein_coding | tolerated(0.11) | benign(0.001) | TCGA-63-A5MR-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKMY2 | SNV | Missense_Mutation | rs753181901 | c.1214N>G | p.Lys405Arg | p.K405R | Q8IV38 | protein_coding | tolerated_low_confidence(0.05) | benign(0.003) | TCGA-CR-7377-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ANKMY2 | SNV | Missense_Mutation | novel | c.235N>A | p.His79Asn | p.H79N | Q8IV38 | protein_coding | tolerated(0.19) | benign(0.057) | TCGA-CV-6935-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ANKMY2 | SNV | Missense_Mutation | novel | c.164N>T | p.Tyr55Phe | p.Y55F | Q8IV38 | protein_coding | tolerated(0.21) | possibly_damaging(0.498) | TCGA-HD-8224-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cetuximab | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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