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Gene: AHCYL1 |
Gene summary for AHCYL1 |
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Gene information | Species | Human | Gene symbol | AHCYL1 | Gene ID | 10768 |
Gene name | adenosylhomocysteinase like 1 | |
Gene Alias | DCAL | |
Cytomap | 1p13.3 | |
Gene Type | protein-coding | GO ID | GO:0002028 | UniProtAcc | O43865 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10768 | AHCYL1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.61e-07 | 6.84e-01 | -0.0811 |
10768 | AHCYL1 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.01e-07 | 6.34e-01 | -0.1088 |
10768 | AHCYL1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.85e-15 | 7.03e-01 | -0.1954 |
10768 | AHCYL1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.47e-04 | 3.89e-01 | -0.1464 |
10768 | AHCYL1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.78e-05 | 6.11e-01 | -0.059 |
10768 | AHCYL1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.42e-04 | 7.17e-01 | 0.0131 |
10768 | AHCYL1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.71e-09 | 5.48e-01 | 0.294 |
10768 | AHCYL1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 9.68e-06 | 6.64e-01 | 0.281 |
10768 | AHCYL1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.86e-11 | 6.70e-01 | 0.3859 |
10768 | AHCYL1 | A015-C-203 | Human | Colorectum | FAP | 3.42e-12 | -2.47e-01 | -0.1294 |
10768 | AHCYL1 | A002-C-201 | Human | Colorectum | FAP | 1.55e-08 | -2.72e-01 | 0.0324 |
10768 | AHCYL1 | A002-C-203 | Human | Colorectum | FAP | 8.04e-03 | -9.98e-02 | 0.2786 |
10768 | AHCYL1 | A001-C-119 | Human | Colorectum | FAP | 6.59e-08 | -3.51e-01 | -0.1557 |
10768 | AHCYL1 | A001-C-108 | Human | Colorectum | FAP | 1.58e-08 | -2.28e-01 | -0.0272 |
10768 | AHCYL1 | A002-C-205 | Human | Colorectum | FAP | 3.75e-10 | -2.66e-01 | -0.1236 |
10768 | AHCYL1 | A015-C-006 | Human | Colorectum | FAP | 3.23e-07 | -2.86e-01 | -0.0994 |
10768 | AHCYL1 | A015-C-106 | Human | Colorectum | FAP | 8.48e-04 | -1.86e-01 | -0.0511 |
10768 | AHCYL1 | A002-C-114 | Human | Colorectum | FAP | 1.67e-07 | -2.22e-01 | -0.1561 |
10768 | AHCYL1 | A015-C-104 | Human | Colorectum | FAP | 2.25e-12 | -2.78e-01 | -0.1899 |
10768 | AHCYL1 | A001-C-014 | Human | Colorectum | FAP | 4.01e-05 | -1.87e-01 | 0.0135 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903311 | Colorectum | AD | regulation of mRNA metabolic process | 117/3918 | 288/18723 | 1.69e-14 | 4.23e-12 | 117 |
GO:0050684 | Colorectum | AD | regulation of mRNA processing | 61/3918 | 137/18723 | 4.23e-10 | 3.58e-08 | 61 |
GO:0006913 | Colorectum | AD | nucleocytoplasmic transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0051169 | Colorectum | AD | nuclear transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:0002028 | Colorectum | AD | regulation of sodium ion transport | 36/3918 | 90/18723 | 2.89e-05 | 5.37e-04 | 36 |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
GO:0051168 | Colorectum | AD | nuclear export | 53/3918 | 154/18723 | 6.89e-05 | 1.11e-03 | 53 |
GO:0010765 | Colorectum | AD | positive regulation of sodium ion transport | 17/3918 | 35/18723 | 2.48e-04 | 3.13e-03 | 17 |
GO:0010038 | Colorectum | AD | response to metal ion | 106/3918 | 373/18723 | 3.22e-04 | 3.83e-03 | 106 |
GO:0006730 | Colorectum | AD | one-carbon metabolic process | 18/3918 | 40/18723 | 5.36e-04 | 5.74e-03 | 18 |
GO:0006611 | Colorectum | AD | protein export from nucleus | 23/3918 | 57/18723 | 6.62e-04 | 6.80e-03 | 23 |
GO:0022406 | Colorectum | AD | membrane docking | 31/3918 | 86/18723 | 8.67e-04 | 8.45e-03 | 31 |
GO:0140056 | Colorectum | AD | organelle localization by membrane tethering | 28/3918 | 77/18723 | 1.29e-03 | 1.14e-02 | 28 |
GO:19033111 | Colorectum | SER | regulation of mRNA metabolic process | 78/2897 | 288/18723 | 2.61e-07 | 1.43e-05 | 78 |
GO:00069131 | Colorectum | SER | nucleocytoplasmic transport | 77/2897 | 301/18723 | 3.39e-06 | 1.32e-04 | 77 |
GO:00511691 | Colorectum | SER | nuclear transport | 77/2897 | 301/18723 | 3.39e-06 | 1.32e-04 | 77 |
GO:00506841 | Colorectum | SER | regulation of mRNA processing | 42/2897 | 137/18723 | 5.57e-06 | 2.01e-04 | 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa002704 | Endometrium | EEC | Cysteine and methionine metabolism | 15/1237 | 52/8465 | 6.02e-03 | 3.12e-02 | 2.33e-02 | 15 |
hsa0027011 | Endometrium | EEC | Cysteine and methionine metabolism | 15/1237 | 52/8465 | 6.02e-03 | 3.12e-02 | 2.33e-02 | 15 |
hsa00270 | Liver | Cirrhotic | Cysteine and methionine metabolism | 27/2530 | 52/8465 | 6.98e-04 | 4.15e-03 | 2.56e-03 | 27 |
hsa002701 | Liver | Cirrhotic | Cysteine and methionine metabolism | 27/2530 | 52/8465 | 6.98e-04 | 4.15e-03 | 2.56e-03 | 27 |
hsa002702 | Liver | HCC | Cysteine and methionine metabolism | 35/4020 | 52/8465 | 3.03e-03 | 9.94e-03 | 5.53e-03 | 35 |
hsa002703 | Liver | HCC | Cysteine and methionine metabolism | 35/4020 | 52/8465 | 3.03e-03 | 9.94e-03 | 5.53e-03 | 35 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AHCYL1 | SNV | Missense_Mutation | novel | c.935N>C | p.Lys312Thr | p.K312T | O43865 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AHCYL1 | SNV | Missense_Mutation | c.1335G>C | p.Leu445Phe | p.L445F | O43865 | protein_coding | deleterious(0) | possibly_damaging(0.792) | TCGA-BC-A112-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
AHCYL1 | SNV | Missense_Mutation | c.361N>A | p.Glu121Lys | p.E121K | O43865 | protein_coding | tolerated(0.07) | possibly_damaging(0.706) | TCGA-62-A46O-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
AHCYL1 | SNV | Missense_Mutation | c.144N>A | p.Met48Ile | p.M48I | O43865 | protein_coding | deleterious_low_confidence(0.02) | benign(0.028) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AHCYL1 | SNV | Missense_Mutation | rs750092870 | c.1420N>A | p.Glu474Lys | p.E474K | O43865 | protein_coding | tolerated(0.13) | benign(0.111) | TCGA-78-7152-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
AHCYL1 | SNV | Missense_Mutation | c.1352N>T | p.Pro451Leu | p.P451L | O43865 | protein_coding | deleterious(0) | possibly_damaging(0.905) | TCGA-99-8025-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | gemzar | SD | |
AHCYL1 | SNV | Missense_Mutation | novel | c.876C>G | p.Cys292Trp | p.C292W | O43865 | protein_coding | deleterious(0.01) | probably_damaging(0.951) | TCGA-77-8131-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AHCYL1 | SNV | Missense_Mutation | novel | c.692N>A | p.Gly231Glu | p.G231E | O43865 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-NC-A5HN-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AHCYL1 | insertion | Frame_Shift_Ins | novel | c.885_886insT | p.Ser296PhefsTer26 | p.S296Ffs*26 | O43865 | protein_coding | TCGA-90-7769-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
AHCYL1 | SNV | Missense_Mutation | novel | c.560N>A | p.Ala187Asp | p.A187D | O43865 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HC-A76X-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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