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Gene: AGRN |
Gene summary for AGRN |
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Gene information | Species | Human | Gene symbol | AGRN | Gene ID | 375790 |
Gene name | agrin | |
Gene Alias | AGRIN | |
Cytomap | 1p36.33 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O00468 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
375790 | AGRN | LZE2T | Human | Esophagus | ESCC | 1.09e-10 | 6.56e-01 | 0.082 |
375790 | AGRN | LZE4T | Human | Esophagus | ESCC | 2.10e-05 | 1.93e-01 | 0.0811 |
375790 | AGRN | LZE5T | Human | Esophagus | ESCC | 4.28e-02 | 3.76e-01 | 0.0514 |
375790 | AGRN | LZE7T | Human | Esophagus | ESCC | 8.79e-05 | 4.67e-01 | 0.0667 |
375790 | AGRN | LZE8T | Human | Esophagus | ESCC | 8.54e-15 | 4.95e-01 | 0.067 |
375790 | AGRN | LZE20T | Human | Esophagus | ESCC | 5.09e-09 | 5.04e-01 | 0.0662 |
375790 | AGRN | LZE21D1 | Human | Esophagus | HGIN | 2.10e-03 | 5.60e-01 | 0.0632 |
375790 | AGRN | LZE22T | Human | Esophagus | ESCC | 1.33e-08 | 4.76e-01 | 0.068 |
375790 | AGRN | LZE24T | Human | Esophagus | ESCC | 2.89e-21 | 6.15e-01 | 0.0596 |
375790 | AGRN | LZE21T | Human | Esophagus | ESCC | 2.09e-03 | 4.31e-01 | 0.0655 |
375790 | AGRN | P1T-E | Human | Esophagus | ESCC | 2.66e-20 | 1.03e+00 | 0.0875 |
375790 | AGRN | P2T-E | Human | Esophagus | ESCC | 6.06e-36 | 5.45e-01 | 0.1177 |
375790 | AGRN | P4T-E | Human | Esophagus | ESCC | 2.20e-22 | 4.69e-01 | 0.1323 |
375790 | AGRN | P5T-E | Human | Esophagus | ESCC | 5.00e-15 | 2.01e-01 | 0.1327 |
375790 | AGRN | P8T-E | Human | Esophagus | ESCC | 8.75e-93 | 1.67e+00 | 0.0889 |
375790 | AGRN | P9T-E | Human | Esophagus | ESCC | 1.18e-17 | 3.97e-01 | 0.1131 |
375790 | AGRN | P10T-E | Human | Esophagus | ESCC | 3.31e-40 | 7.28e-01 | 0.116 |
375790 | AGRN | P11T-E | Human | Esophagus | ESCC | 4.07e-23 | 1.27e+00 | 0.1426 |
375790 | AGRN | P12T-E | Human | Esophagus | ESCC | 1.77e-20 | 3.74e-01 | 0.1122 |
375790 | AGRN | P15T-E | Human | Esophagus | ESCC | 3.48e-43 | 9.87e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:006049117 | Esophagus | HGIN | regulation of cell projection assembly | 39/2587 | 188/18723 | 5.61e-03 | 4.57e-02 | 39 |
GO:003134616 | Esophagus | ESCC | positive regulation of cell projection organization | 201/8552 | 353/18723 | 1.19e-05 | 1.11e-04 | 201 |
GO:006049118 | Esophagus | ESCC | regulation of cell projection assembly | 110/8552 | 188/18723 | 2.60e-04 | 1.58e-03 | 110 |
GO:003432918 | Esophagus | ESCC | cell junction assembly | 227/8552 | 420/18723 | 3.06e-04 | 1.83e-03 | 227 |
GO:012003218 | Esophagus | ESCC | regulation of plasma membrane bounded cell projection assembly | 108/8552 | 186/18723 | 4.37e-04 | 2.46e-03 | 108 |
GO:00519606 | Esophagus | ESCC | regulation of nervous system development | 237/8552 | 443/18723 | 5.02e-04 | 2.78e-03 | 237 |
GO:01200347 | Esophagus | ESCC | positive regulation of plasma membrane bounded cell projection assembly | 64/8552 | 105/18723 | 1.15e-03 | 5.70e-03 | 64 |
GO:00519625 | Esophagus | ESCC | positive regulation of nervous system development | 149/8552 | 272/18723 | 1.50e-03 | 7.06e-03 | 149 |
GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
GO:004592717 | Esophagus | ESCC | positive regulation of growth | 137/8552 | 259/18723 | 1.13e-02 | 3.80e-02 | 137 |
GO:190188810 | Esophagus | ESCC | regulation of cell junction assembly | 109/8552 | 204/18723 | 1.53e-02 | 4.96e-02 | 109 |
GO:01200326 | Liver | Cirrhotic | regulation of plasma membrane bounded cell projection assembly | 63/4634 | 186/18723 | 3.16e-03 | 1.78e-02 | 63 |
GO:00604915 | Liver | Cirrhotic | regulation of cell projection assembly | 63/4634 | 188/18723 | 4.17e-03 | 2.22e-02 | 63 |
GO:003134611 | Liver | HCC | positive regulation of cell projection organization | 193/7958 | 353/18723 | 2.28e-06 | 3.08e-05 | 193 |
GO:006049112 | Liver | HCC | regulation of cell projection assembly | 101/7958 | 188/18723 | 1.20e-03 | 6.69e-03 | 101 |
GO:012003212 | Liver | HCC | regulation of plasma membrane bounded cell projection assembly | 100/7958 | 186/18723 | 1.23e-03 | 6.81e-03 | 100 |
GO:01200344 | Liver | HCC | positive regulation of plasma membrane bounded cell projection assembly | 58/7958 | 105/18723 | 5.66e-03 | 2.36e-02 | 58 |
GO:004592711 | Liver | HCC | positive regulation of growth | 128/7958 | 259/18723 | 1.41e-02 | 4.99e-02 | 128 |
GO:003134610 | Oral cavity | OSCC | positive regulation of cell projection organization | 176/7305 | 353/18723 | 1.94e-05 | 1.87e-04 | 176 |
GO:006049110 | Oral cavity | OSCC | regulation of cell projection assembly | 100/7305 | 188/18723 | 5.27e-05 | 4.38e-04 | 100 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
AGRN | DAG1 | AGRN_DAG1 | AGRN | Cervix | Precancer |
AGRN | DAG1 | AGRN_DAG1 | AGRN | CRC | MSI-H |
AGRN | DAG1 | AGRN_DAG1 | AGRN | Esophagus | ADJ |
AGRN | DAG1 | AGRN_DAG1 | AGRN | Esophagus | ESCC |
AGRN | DAG1 | AGRN_DAG1 | AGRN | HNSCC | ADJ |
AGRN | DAG1 | AGRN_DAG1 | AGRN | HNSCC | OSCC |
AGRN | DAG1 | AGRN_DAG1 | AGRN | HNSCC | Precancer |
AGRN | DAG1 | AGRN_DAG1 | AGRN | Liver | HCC |
AGRN | DAG1 | AGRN_DAG1 | AGRN | Lung | AAH |
AGRN | DAG1 | AGRN_DAG1 | AGRN | Prostate | Tumor |
AGRN | DAG1 | AGRN_DAG1 | AGRN | Skin | cSCC |
AGRN | DAG1 | AGRN_DAG1 | AGRN | THCA | ADJ |
AGRN | DAG1 | AGRN_DAG1 | AGRN | THCA | Cancer |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AGRN | insertion | Frame_Shift_Ins | novel | c.2191_2192insTGAAGAAGGCCAGG | p.Cys736Ter | p.C736* | O00468 | protein_coding | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
AGRN | deletion | Frame_Shift_Del | c.1875delN | p.Pro627ArgfsTer105 | p.P627Rfs*105 | O00468 | protein_coding | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
AGRN | deletion | Frame_Shift_Del | c.1875delN | p.Pro627ArgfsTer105 | p.P627Rfs*105 | O00468 | protein_coding | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
AGRN | deletion | Frame_Shift_Del | c.3012delN | p.Leu1006TrpfsTer34 | p.L1006Wfs*34 | O00468 | protein_coding | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
AGRN | insertion | Frame_Shift_Ins | rs776252707 | c.3003dupC | p.Gly1002ArgfsTer58 | p.G1002Rfs*58 | O00468 | protein_coding | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
AGRN | deletion | Frame_Shift_Del | rs763573703 | c.2996delN | p.Gly1002AlafsTer38 | p.G1002Afs*38 | O00468 | protein_coding | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
AGRN | insertion | Frame_Shift_Ins | rs776252707 | c.3003dupC | p.Gly1002ArgfsTer58 | p.G1002Rfs*58 | O00468 | protein_coding | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | ||
AGRN | insertion | Frame_Shift_Ins | novel | c.5248_5249insCCCC | p.Val1752ProfsTer120 | p.V1752Pfs*120 | O00468 | protein_coding | TCGA-EI-6512-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folfox | SD | ||
AGRN | SNV | Missense_Mutation | rs772386655 | c.2903C>T | p.Pro968Leu | p.P968L | O00468 | protein_coding | deleterious(0.04) | benign(0.274) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AGRN | SNV | Missense_Mutation | novel | c.287G>T | p.Gly96Val | p.G96V | O00468 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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