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Gene: ADGRF4 |
Gene summary for ADGRF4 |
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Gene information | Species | Human | Gene symbol | ADGRF4 | Gene ID | 221393 |
Gene name | adhesion G protein-coupled receptor F4 | |
Gene Alias | GPR115 | |
Cytomap | 6p12.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q8IZF3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221393 | ADGRF4 | P31T-E | Human | Esophagus | ESCC | 6.19e-03 | 1.47e-01 | 0.1251 |
221393 | ADGRF4 | P37T-E | Human | Esophagus | ESCC | 2.67e-02 | 6.23e-02 | 0.1371 |
221393 | ADGRF4 | P44T-E | Human | Esophagus | ESCC | 6.06e-03 | 1.59e-01 | 0.1096 |
221393 | ADGRF4 | P47T-E | Human | Esophagus | ESCC | 8.35e-04 | 9.76e-02 | 0.1067 |
221393 | ADGRF4 | P49T-E | Human | Esophagus | ESCC | 2.63e-03 | 5.04e-01 | 0.1768 |
221393 | ADGRF4 | P61T-E | Human | Esophagus | ESCC | 3.13e-02 | 1.86e-01 | 0.099 |
221393 | ADGRF4 | P62T-E | Human | Esophagus | ESCC | 2.51e-02 | 1.10e-01 | 0.1302 |
221393 | ADGRF4 | P65T-E | Human | Esophagus | ESCC | 1.48e-02 | 1.16e-01 | 0.0978 |
221393 | ADGRF4 | P75T-E | Human | Esophagus | ESCC | 2.55e-04 | 1.43e-01 | 0.1125 |
221393 | ADGRF4 | P80T-E | Human | Esophagus | ESCC | 5.61e-27 | 1.00e+00 | 0.155 |
221393 | ADGRF4 | P130T-E | Human | Esophagus | ESCC | 8.86e-18 | 4.12e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADGRF4 | SNV | Missense_Mutation | novel | c.473G>A | p.Gly158Glu | p.G158E | Q8IZF3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ADGRF4 | SNV | Missense_Mutation | c.822G>T | p.Gln274His | p.Q274H | Q8IZF3 | protein_coding | tolerated(0.52) | benign(0.169) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
ADGRF4 | SNV | Missense_Mutation | novel | c.1979G>T | p.Arg660Ile | p.R660I | Q8IZF3 | protein_coding | deleterious(0) | possibly_damaging(0.902) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ADGRF4 | SNV | Missense_Mutation | c.1627N>C | p.Tyr543His | p.Y543H | Q8IZF3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A0JV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ADGRF4 | SNV | Missense_Mutation | rs772794418 | c.368N>A | p.Arg123Gln | p.R123Q | Q8IZF3 | protein_coding | tolerated(0.48) | benign(0) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
ADGRF4 | SNV | Missense_Mutation | novel | c.504N>C | p.Lys168Asn | p.K168N | Q8IZF3 | protein_coding | tolerated(0.11) | benign(0.357) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
ADGRF4 | SNV | Missense_Mutation | c.60A>C | p.Glu20Asp | p.E20D | Q8IZF3 | protein_coding | deleterious(0.01) | benign(0.441) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ADGRF4 | SNV | Missense_Mutation | novel | c.1979G>T | p.Arg660Ile | p.R660I | Q8IZF3 | protein_coding | deleterious(0) | possibly_damaging(0.902) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ADGRF4 | SNV | Missense_Mutation | rs745953561 | c.892N>G | p.Leu298Val | p.L298V | Q8IZF3 | protein_coding | deleterious(0) | probably_damaging(0.931) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADGRF4 | SNV | Missense_Mutation | novel | c.362A>T | p.Asp121Val | p.D121V | Q8IZF3 | protein_coding | tolerated(0.13) | benign(0.005) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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