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Gene: ADCK2 |
Gene summary for ADCK2 |
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Gene information | Species | Human | Gene symbol | ADCK2 | Gene ID | 90956 |
Gene name | aarF domain containing kinase 2 | |
Gene Alias | AARF | |
Cytomap | 7q34 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A4D1T6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90956 | ADCK2 | C04 | Human | Oral cavity | OSCC | 5.33e-06 | 2.83e-01 | 0.2633 |
90956 | ADCK2 | C21 | Human | Oral cavity | OSCC | 4.77e-12 | 3.53e-01 | 0.2678 |
90956 | ADCK2 | C30 | Human | Oral cavity | OSCC | 8.66e-24 | 8.13e-01 | 0.3055 |
90956 | ADCK2 | C43 | Human | Oral cavity | OSCC | 1.71e-09 | 2.56e-01 | 0.1704 |
90956 | ADCK2 | C46 | Human | Oral cavity | OSCC | 4.37e-13 | 3.20e-01 | 0.1673 |
90956 | ADCK2 | C51 | Human | Oral cavity | OSCC | 5.38e-09 | 3.87e-01 | 0.2674 |
90956 | ADCK2 | C06 | Human | Oral cavity | OSCC | 3.12e-02 | 4.20e-01 | 0.2699 |
90956 | ADCK2 | C08 | Human | Oral cavity | OSCC | 9.84e-24 | 5.26e-01 | 0.1919 |
90956 | ADCK2 | C09 | Human | Oral cavity | OSCC | 4.58e-07 | 1.91e-01 | 0.1431 |
90956 | ADCK2 | LN46 | Human | Oral cavity | OSCC | 3.39e-07 | 2.81e-01 | 0.1666 |
90956 | ADCK2 | LP15 | Human | Oral cavity | LP | 2.31e-02 | 4.38e-01 | 0.2174 |
90956 | ADCK2 | SYSMH1 | Human | Oral cavity | OSCC | 5.10e-07 | 1.99e-01 | 0.1127 |
90956 | ADCK2 | SYSMH2 | Human | Oral cavity | OSCC | 2.97e-12 | 3.35e-01 | 0.2326 |
90956 | ADCK2 | SYSMH3 | Human | Oral cavity | OSCC | 3.03e-03 | 2.13e-01 | 0.2442 |
90956 | ADCK2 | male-WTA | Human | Thyroid | PTC | 7.21e-03 | 7.91e-02 | 0.1037 |
90956 | ADCK2 | PTC01 | Human | Thyroid | PTC | 1.14e-03 | 1.29e-01 | 0.1899 |
90956 | ADCK2 | PTC04 | Human | Thyroid | PTC | 5.99e-03 | 9.48e-02 | 0.1927 |
90956 | ADCK2 | PTC05 | Human | Thyroid | PTC | 4.36e-13 | 3.02e-01 | 0.2065 |
90956 | ADCK2 | PTC06 | Human | Thyroid | PTC | 2.83e-16 | 2.64e-01 | 0.2057 |
90956 | ADCK2 | PTC07 | Human | Thyroid | PTC | 2.60e-12 | 2.31e-01 | 0.2044 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADCK2 | SNV | Missense_Mutation | c.317N>G | p.Leu106Arg | p.L106R | Q7Z695 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-49-AAR3-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ADCK2 | SNV | Missense_Mutation | rs561363159 | c.1699N>C | p.Ser567Arg | p.S567R | Q7Z695 | protein_coding | tolerated(0.15) | benign(0.007) | TCGA-55-7574-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
ADCK2 | SNV | Missense_Mutation | c.1273N>C | p.Ala425Pro | p.A425P | Q7Z695 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-67-3770-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ADCK2 | SNV | Missense_Mutation | c.98G>A | p.Cys33Tyr | p.C33Y | Q7Z695 | protein_coding | tolerated_low_confidence(0.14) | benign(0) | TCGA-63-5128-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | PD | |
ADCK2 | SNV | Missense_Mutation | novel | c.1277N>C | p.Arg426Pro | p.R426P | Q7Z695 | protein_coding | deleterious(0.02) | benign(0.212) | TCGA-CN-4739-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
ADCK2 | SNV | Missense_Mutation | novel | c.106N>T | p.Asp36Tyr | p.D36Y | Q7Z695 | protein_coding | deleterious(0.01) | benign(0.031) | TCGA-CV-6936-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ADCK2 | SNV | Missense_Mutation | novel | c.1847N>T | p.Pro616Leu | p.P616L | Q7Z695 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADCK2 | SNV | Missense_Mutation | c.1117T>G | p.Phe373Val | p.F373V | Q7Z695 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-HU-A4GH-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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