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Gene: ADAMTSL1 |
Gene summary for ADAMTSL1 |
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Gene information | Species | Human | Gene symbol | ADAMTSL1 | Gene ID | 92949 |
Gene name | ADAMTS like 1 | |
Gene Alias | ADAMTSL-1 | |
Cytomap | 9p22.2-p22.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6MZQ3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92949 | ADAMTSL1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.73e-38 | -9.48e-01 | 0.0155 |
92949 | ADAMTSL1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.54e-07 | -5.04e-01 | -0.1808 |
92949 | ADAMTSL1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 9.41e-14 | -9.90e-01 | 0.0216 |
92949 | ADAMTSL1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.41e-03 | -5.83e-01 | -0.0811 |
92949 | ADAMTSL1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.05e-06 | -2.93e-01 | -0.1088 |
92949 | ADAMTSL1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.05e-37 | 1.70e+00 | -0.1954 |
92949 | ADAMTSL1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.90e-16 | 1.70e-01 | -0.2602 |
92949 | ADAMTSL1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.07e-12 | -1.16e+00 | -0.2196 |
92949 | ADAMTSL1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.35e-06 | -6.08e-01 | -0.1207 |
92949 | ADAMTSL1 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.29e-14 | 8.46e-01 | -0.1526 |
92949 | ADAMTSL1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.35e-08 | -7.90e-03 | -0.1464 |
92949 | ADAMTSL1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.45e-14 | 4.76e-01 | -0.1001 |
92949 | ADAMTSL1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.85e-17 | -7.98e-01 | -0.059 |
92949 | ADAMTSL1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.46e-07 | 1.07e-01 | -0.1706 |
92949 | ADAMTSL1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 8.82e-03 | 3.80e-01 | -0.1462 |
92949 | ADAMTSL1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.78e-03 | 2.39e-01 | -0.0842 |
92949 | ADAMTSL1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.12e-18 | 9.91e-01 | -0.0179 |
92949 | ADAMTSL1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.48e-16 | -7.55e-01 | 0.096 |
92949 | ADAMTSL1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.12e-03 | -6.72e-01 | 0.0446 |
92949 | ADAMTSL1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.45e-10 | -1.14e+00 | 0.0451 |
Page: 1 2 3 4 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAMTSL1 | SNV | Missense_Mutation | rs368567865 | c.4175N>T | p.Pro1392Leu | p.P1392L | Q8N6G6 | protein_coding | tolerated(0.42) | benign(0) | TCGA-A6-A566-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | PD |
ADAMTSL1 | SNV | Missense_Mutation | c.1588N>T | p.Ala530Ser | p.A530S | Q8N6G6 | protein_coding | tolerated(0.1) | benign(0.038) | TCGA-AA-3495-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ADAMTSL1 | SNV | Missense_Mutation | rs764202410 | c.997N>A | p.Val333Ile | p.V333I | Q8N6G6 | protein_coding | deleterious(0.01) | possibly_damaging(0.882) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ADAMTSL1 | SNV | Missense_Mutation | rs373837581 | c.4162G>A | p.Ala1388Thr | p.A1388T | Q8N6G6 | protein_coding | tolerated(0.39) | benign(0.015) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
ADAMTSL1 | SNV | Missense_Mutation | c.1103N>G | p.Ile368Ser | p.I368S | Q8N6G6 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ADAMTSL1 | SNV | Missense_Mutation | rs771200194 | c.425C>T | p.Thr142Met | p.T142M | Q8N6G6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3867-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ADAMTSL1 | SNV | Missense_Mutation | c.1105N>G | p.Met369Val | p.M369V | Q8N6G6 | protein_coding | deleterious(0.01) | possibly_damaging(0.719) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ADAMTSL1 | SNV | Missense_Mutation | rs752983559 | c.724N>G | p.Ser242Gly | p.S242G | Q8N6G6 | protein_coding | tolerated(0.17) | benign(0.444) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ADAMTSL1 | SNV | Missense_Mutation | c.2165N>T | p.Ala722Val | p.A722V | Q8N6G6 | protein_coding | deleterious(0.04) | benign(0.029) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ADAMTSL1 | SNV | Missense_Mutation | rs747836852 | c.2156C>T | p.Thr719Met | p.T719M | Q8N6G6 | protein_coding | tolerated(0.06) | benign(0.015) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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