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Gene: ACTR2 |
Gene summary for ACTR2 |
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Gene information | Species | Human | Gene symbol | ACTR2 | Gene ID | 10097 |
Gene name | actin related protein 2 | |
Gene Alias | ARP2 | |
Cytomap | 2p14 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P61160 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10097 | ACTR2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.06e-04 | 5.85e-01 | -0.0811 |
10097 | ACTR2 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.90e-09 | 6.42e-01 | -0.1088 |
10097 | ACTR2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.89e-29 | 9.25e-01 | -0.1954 |
10097 | ACTR2 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.62e-03 | 7.85e-01 | -0.2602 |
10097 | ACTR2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.20e-02 | 6.54e-01 | -0.2196 |
10097 | ACTR2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.49e-05 | 5.29e-01 | -0.059 |
10097 | ACTR2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 8.18e-09 | 7.22e-01 | 0.281 |
10097 | ACTR2 | A015-C-203 | Human | Colorectum | FAP | 3.93e-28 | -4.57e-01 | -0.1294 |
10097 | ACTR2 | A015-C-204 | Human | Colorectum | FAP | 9.41e-04 | -1.74e-01 | -0.0228 |
10097 | ACTR2 | A014-C-040 | Human | Colorectum | FAP | 9.70e-04 | -5.24e-01 | -0.1184 |
10097 | ACTR2 | A002-C-201 | Human | Colorectum | FAP | 5.06e-08 | -1.30e-01 | 0.0324 |
10097 | ACTR2 | A002-C-203 | Human | Colorectum | FAP | 8.11e-04 | -6.35e-02 | 0.2786 |
10097 | ACTR2 | A001-C-119 | Human | Colorectum | FAP | 1.71e-10 | -4.84e-01 | -0.1557 |
10097 | ACTR2 | A001-C-108 | Human | Colorectum | FAP | 4.84e-17 | -2.44e-01 | -0.0272 |
10097 | ACTR2 | A002-C-205 | Human | Colorectum | FAP | 1.33e-15 | -2.40e-01 | -0.1236 |
10097 | ACTR2 | A001-C-104 | Human | Colorectum | FAP | 8.60e-09 | -2.75e-01 | 0.0184 |
10097 | ACTR2 | A015-C-005 | Human | Colorectum | FAP | 4.31e-03 | -2.45e-01 | -0.0336 |
10097 | ACTR2 | A015-C-006 | Human | Colorectum | FAP | 6.67e-13 | -4.70e-01 | -0.0994 |
10097 | ACTR2 | A015-C-106 | Human | Colorectum | FAP | 8.79e-16 | -3.74e-01 | -0.0511 |
10097 | ACTR2 | A002-C-114 | Human | Colorectum | FAP | 2.54e-14 | -4.00e-01 | -0.1561 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0008064 | Colorectum | AD | regulation of actin polymerization or depolymerization | 79/3918 | 188/18723 | 4.17e-11 | 4.74e-09 | 79 |
GO:0030833 | Colorectum | AD | regulation of actin filament polymerization | 74/3918 | 172/18723 | 4.50e-11 | 5.03e-09 | 74 |
GO:0030832 | Colorectum | AD | regulation of actin filament length | 79/3918 | 189/18723 | 5.71e-11 | 6.27e-09 | 79 |
GO:1902905 | Colorectum | AD | positive regulation of supramolecular fiber organization | 85/3918 | 209/18723 | 5.95e-11 | 6.33e-09 | 85 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:0051495 | Colorectum | AD | positive regulation of cytoskeleton organization | 89/3918 | 226/18723 | 1.61e-10 | 1.56e-08 | 89 |
GO:0032273 | Colorectum | AD | positive regulation of protein polymerization | 62/3918 | 138/18723 | 1.94e-10 | 1.76e-08 | 62 |
GO:0031334 | Colorectum | AD | positive regulation of protein-containing complex assembly | 91/3918 | 237/18723 | 4.78e-10 | 3.99e-08 | 91 |
GO:0030838 | Colorectum | AD | positive regulation of actin filament polymerization | 48/3918 | 99/18723 | 9.21e-10 | 7.03e-08 | 48 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa05100 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa04530 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa05132 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa04666 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa05130 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa05135 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa04810 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051001 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa045301 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa051321 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa046661 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa051301 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa051351 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa048101 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa051002 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACTR2 | SNV | Missense_Mutation | novel | c.1158N>T | p.Lys386Asn | p.K386N | P61160 | protein_coding | tolerated(0.32) | benign(0.026) | TCGA-18-3416-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ACTR2 | SNV | Missense_Mutation | novel | c.797C>G | p.Ala266Gly | p.A266G | P61160 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-52-7812-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | paclitaxel | PD |
ACTR2 | SNV | Missense_Mutation | novel | c.920T>C | p.Val307Ala | p.V307A | P61160 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-63-A5MB-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
ACTR2 | SNV | Missense_Mutation | novel | c.874C>G | p.Gln292Glu | p.Q292E | P61160 | protein_coding | deleterious(0.03) | benign(0.382) | TCGA-85-8276-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
ACTR2 | deletion | Frame_Shift_Del | c.373_376delNNNN | p.Glu126ArgfsTer3 | p.E126Rfs*3 | P61160 | protein_coding | TCGA-49-4506-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
ACTR2 | SNV | Missense_Mutation | novel | c.333N>T | p.Lys111Asn | p.K111N | P61160 | protein_coding | tolerated(0.07) | probably_damaging(0.99) | TCGA-CN-4735-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | vectibix | SD |
ACTR2 | SNV | Missense_Mutation | c.1043N>A | p.Arg348His | p.R348H | P61160 | protein_coding | deleterious(0.02) | possibly_damaging(0.807) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ACTR2 | SNV | Missense_Mutation | c.625N>C | p.Phe209Leu | p.F209L | P61160 | protein_coding | tolerated(0.16) | possibly_damaging(0.849) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10097 | ACTR2 | NA | ETOPOSIDE | ETOPOSIDE | 15900709 | |
10097 | ACTR2 | NA | MCP-1 | 16004967 |
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