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Gene: ACOT9 |
Gene summary for ACOT9 |
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Gene information | Species | Human | Gene symbol | ACOT9 | Gene ID | 23597 |
Gene name | acyl-CoA thioesterase 9 | |
Gene Alias | ACATE2 | |
Cytomap | Xp22.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9Y305 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23597 | ACOT9 | LZE4T | Human | Esophagus | ESCC | 7.14e-14 | 3.87e-01 | 0.0811 |
23597 | ACOT9 | LZE7T | Human | Esophagus | ESCC | 2.65e-08 | 4.58e-01 | 0.0667 |
23597 | ACOT9 | LZE8T | Human | Esophagus | ESCC | 5.54e-06 | 2.95e-01 | 0.067 |
23597 | ACOT9 | LZE22T | Human | Esophagus | ESCC | 3.24e-06 | 2.69e-01 | 0.068 |
23597 | ACOT9 | LZE24T | Human | Esophagus | ESCC | 1.37e-04 | 8.57e-02 | 0.0596 |
23597 | ACOT9 | LZE6T | Human | Esophagus | ESCC | 2.19e-06 | 2.20e-01 | 0.0845 |
23597 | ACOT9 | P1T-E | Human | Esophagus | ESCC | 1.78e-04 | 1.76e-01 | 0.0875 |
23597 | ACOT9 | P2T-E | Human | Esophagus | ESCC | 1.04e-10 | 3.21e-01 | 0.1177 |
23597 | ACOT9 | P4T-E | Human | Esophagus | ESCC | 5.82e-19 | 3.51e-01 | 0.1323 |
23597 | ACOT9 | P5T-E | Human | Esophagus | ESCC | 5.91e-24 | 5.43e-01 | 0.1327 |
23597 | ACOT9 | P8T-E | Human | Esophagus | ESCC | 6.63e-32 | 5.90e-01 | 0.0889 |
23597 | ACOT9 | P9T-E | Human | Esophagus | ESCC | 8.51e-10 | 2.19e-01 | 0.1131 |
23597 | ACOT9 | P10T-E | Human | Esophagus | ESCC | 3.49e-14 | 2.53e-01 | 0.116 |
23597 | ACOT9 | P11T-E | Human | Esophagus | ESCC | 1.07e-16 | 6.88e-01 | 0.1426 |
23597 | ACOT9 | P12T-E | Human | Esophagus | ESCC | 9.43e-19 | 4.38e-01 | 0.1122 |
23597 | ACOT9 | P15T-E | Human | Esophagus | ESCC | 1.06e-08 | 1.96e-01 | 0.1149 |
23597 | ACOT9 | P16T-E | Human | Esophagus | ESCC | 1.48e-18 | 3.33e-01 | 0.1153 |
23597 | ACOT9 | P17T-E | Human | Esophagus | ESCC | 2.40e-09 | 3.50e-01 | 0.1278 |
23597 | ACOT9 | P19T-E | Human | Esophagus | ESCC | 2.98e-11 | 1.74e+00 | 0.1662 |
23597 | ACOT9 | P20T-E | Human | Esophagus | ESCC | 7.13e-04 | 8.86e-02 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
GO:0019693111 | Esophagus | ESCC | ribose phosphate metabolic process | 234/8552 | 396/18723 | 4.24e-08 | 7.76e-07 | 234 |
GO:0009117111 | Esophagus | ESCC | nucleotide metabolic process | 282/8552 | 489/18723 | 4.70e-08 | 8.50e-07 | 282 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:0009259111 | Esophagus | ESCC | ribonucleotide metabolic process | 224/8552 | 385/18723 | 4.41e-07 | 6.00e-06 | 224 |
GO:0072521111 | Esophagus | ESCC | purine-containing compound metabolic process | 238/8552 | 416/18723 | 1.20e-06 | 1.49e-05 | 238 |
GO:0009150111 | Esophagus | ESCC | purine ribonucleotide metabolic process | 213/8552 | 368/18723 | 1.40e-06 | 1.69e-05 | 213 |
GO:0006163111 | Esophagus | ESCC | purine nucleotide metabolic process | 226/8552 | 396/18723 | 2.81e-06 | 3.21e-05 | 226 |
GO:00338655 | Esophagus | ESCC | nucleoside bisphosphate metabolic process | 77/8552 | 128/18723 | 6.71e-04 | 3.55e-03 | 77 |
GO:00338755 | Esophagus | ESCC | ribonucleoside bisphosphate metabolic process | 77/8552 | 128/18723 | 6.71e-04 | 3.55e-03 | 77 |
GO:00340325 | Esophagus | ESCC | purine nucleoside bisphosphate metabolic process | 77/8552 | 128/18723 | 6.71e-04 | 3.55e-03 | 77 |
GO:00066374 | Esophagus | ESCC | acyl-CoA metabolic process | 55/8552 | 96/18723 | 1.45e-02 | 4.71e-02 | 55 |
GO:00353834 | Esophagus | ESCC | thioester metabolic process | 55/8552 | 96/18723 | 1.45e-02 | 4.71e-02 | 55 |
GO:000911722 | Liver | HCC | nucleotide metabolic process | 300/7958 | 489/18723 | 1.61e-17 | 1.71e-15 | 300 |
GO:000675322 | Liver | HCC | nucleoside phosphate metabolic process | 304/7958 | 497/18723 | 1.78e-17 | 1.85e-15 | 304 |
GO:001969322 | Liver | HCC | ribose phosphate metabolic process | 248/7958 | 396/18723 | 3.15e-16 | 2.70e-14 | 248 |
GO:000925922 | Liver | HCC | ribonucleotide metabolic process | 240/7958 | 385/18723 | 2.07e-15 | 1.51e-13 | 240 |
GO:000679021 | Liver | HCC | sulfur compound metabolic process | 212/7958 | 339/18723 | 5.60e-14 | 3.39e-12 | 212 |
GO:000915022 | Liver | HCC | purine ribonucleotide metabolic process | 226/7958 | 368/18723 | 1.36e-13 | 7.69e-12 | 226 |
GO:007252122 | Liver | HCC | purine-containing compound metabolic process | 250/7958 | 416/18723 | 2.26e-13 | 1.24e-11 | 250 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACOT9 | SNV | Missense_Mutation | novel | c.484N>T | p.Asp162Tyr | p.D162Y | Q9Y305 | protein_coding | deleterious(0.01) | possibly_damaging(0.789) | TCGA-95-A4VN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ACOT9 | SNV | Missense_Mutation | novel | c.1289N>G | p.His430Arg | p.H430R | Q9Y305 | protein_coding | deleterious(0.05) | possibly_damaging(0.785) | TCGA-J2-A4AD-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ACOT9 | SNV | Missense_Mutation | novel | c.608N>T | p.Cys203Phe | p.C203F | Q9Y305 | protein_coding | tolerated(0.72) | benign(0) | TCGA-L3-A524-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ACOT9 | SNV | Missense_Mutation | rs754131492 | c.1025N>T | p.Ser342Phe | p.S342F | Q9Y305 | protein_coding | deleterious(0) | possibly_damaging(0.847) | TCGA-CR-7370-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ACOT9 | SNV | Missense_Mutation | novel | c.937C>T | p.Arg313Trp | p.R313W | Q9Y305 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ACOT9 | SNV | Missense_Mutation | c.760T>A | p.Ser254Thr | p.S254T | Q9Y305 | protein_coding | tolerated(0.97) | benign(0) | TCGA-F1-6875-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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