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Gene: ABI2 |
Gene summary for ABI2 |
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Gene information | Species | Human | Gene symbol | ABI2 | Gene ID | 10152 |
Gene name | abl interactor 2 | |
Gene Alias | ABI-2 | |
Cytomap | 2q33.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | F8WAL6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10152 | ABI2 | LZE7T | Human | Esophagus | ESCC | 4.32e-14 | 4.83e-01 | 0.0667 |
10152 | ABI2 | LZE20T | Human | Esophagus | ESCC | 1.71e-03 | 6.07e-02 | 0.0662 |
10152 | ABI2 | LZE24T | Human | Esophagus | ESCC | 1.53e-14 | 4.69e-01 | 0.0596 |
10152 | ABI2 | P1T-E | Human | Esophagus | ESCC | 1.03e-02 | 3.34e-01 | 0.0875 |
10152 | ABI2 | P2T-E | Human | Esophagus | ESCC | 8.19e-37 | 7.02e-01 | 0.1177 |
10152 | ABI2 | P4T-E | Human | Esophagus | ESCC | 1.28e-27 | 6.33e-01 | 0.1323 |
10152 | ABI2 | P5T-E | Human | Esophagus | ESCC | 6.16e-11 | 2.27e-01 | 0.1327 |
10152 | ABI2 | P8T-E | Human | Esophagus | ESCC | 1.30e-21 | 4.23e-01 | 0.0889 |
10152 | ABI2 | P9T-E | Human | Esophagus | ESCC | 1.95e-09 | 3.15e-01 | 0.1131 |
10152 | ABI2 | P10T-E | Human | Esophagus | ESCC | 7.36e-38 | 5.71e-01 | 0.116 |
10152 | ABI2 | P11T-E | Human | Esophagus | ESCC | 4.29e-08 | 4.45e-01 | 0.1426 |
10152 | ABI2 | P12T-E | Human | Esophagus | ESCC | 1.80e-37 | 7.29e-01 | 0.1122 |
10152 | ABI2 | P15T-E | Human | Esophagus | ESCC | 7.06e-34 | 8.19e-01 | 0.1149 |
10152 | ABI2 | P16T-E | Human | Esophagus | ESCC | 4.74e-35 | 6.66e-01 | 0.1153 |
10152 | ABI2 | P17T-E | Human | Esophagus | ESCC | 4.83e-04 | 2.91e-01 | 0.1278 |
10152 | ABI2 | P20T-E | Human | Esophagus | ESCC | 2.18e-11 | 3.14e-01 | 0.1124 |
10152 | ABI2 | P21T-E | Human | Esophagus | ESCC | 3.77e-13 | 2.75e-01 | 0.1617 |
10152 | ABI2 | P22T-E | Human | Esophagus | ESCC | 2.64e-30 | 5.39e-01 | 0.1236 |
10152 | ABI2 | P23T-E | Human | Esophagus | ESCC | 4.58e-11 | 2.42e-01 | 0.108 |
10152 | ABI2 | P24T-E | Human | Esophagus | ESCC | 1.26e-28 | 4.86e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
GO:0031334111 | Esophagus | ESCC | positive regulation of protein-containing complex assembly | 166/8552 | 237/18723 | 2.06e-14 | 1.07e-12 | 166 |
GO:1902905111 | Esophagus | ESCC | positive regulation of supramolecular fiber organization | 142/8552 | 209/18723 | 5.51e-11 | 1.76e-09 | 142 |
GO:1902903111 | Esophagus | ESCC | regulation of supramolecular fiber organization | 237/8552 | 383/18723 | 9.06e-11 | 2.75e-09 | 237 |
GO:005149520 | Esophagus | ESCC | positive regulation of cytoskeleton organization | 147/8552 | 226/18723 | 2.93e-09 | 6.38e-08 | 147 |
GO:0051258111 | Esophagus | ESCC | protein polymerization | 183/8552 | 297/18723 | 1.94e-08 | 3.75e-07 | 183 |
GO:000701527 | Esophagus | ESCC | actin filament organization | 259/8552 | 442/18723 | 2.37e-08 | 4.50e-07 | 259 |
GO:0032273111 | Esophagus | ESCC | positive regulation of protein polymerization | 95/8552 | 138/18723 | 2.97e-08 | 5.57e-07 | 95 |
GO:003253520 | Esophagus | ESCC | regulation of cellular component size | 227/8552 | 383/18723 | 4.77e-08 | 8.60e-07 | 227 |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:0032970111 | Esophagus | ESCC | regulation of actin filament-based process | 231/8552 | 397/18723 | 2.91e-07 | 4.20e-06 | 231 |
GO:0032956111 | Esophagus | ESCC | regulation of actin cytoskeleton organization | 210/8552 | 358/18723 | 4.40e-07 | 6.00e-06 | 210 |
GO:0032271111 | Esophagus | ESCC | regulation of protein polymerization | 143/8552 | 233/18723 | 9.21e-07 | 1.17e-05 | 143 |
GO:000206420 | Esophagus | ESCC | epithelial cell development | 136/8552 | 220/18723 | 9.50e-07 | 1.21e-05 | 136 |
GO:011005327 | Esophagus | ESCC | regulation of actin filament organization | 166/8552 | 278/18723 | 1.54e-06 | 1.85e-05 | 166 |
GO:003134616 | Esophagus | ESCC | positive regulation of cell projection organization | 201/8552 | 353/18723 | 1.19e-05 | 1.11e-04 | 201 |
GO:00166019 | Esophagus | ESCC | Rac protein signal transduction | 33/8552 | 42/18723 | 1.35e-05 | 1.23e-04 | 33 |
GO:003083819 | Esophagus | ESCC | positive regulation of actin filament polymerization | 66/8552 | 99/18723 | 1.96e-05 | 1.72e-04 | 66 |
GO:000815420 | Esophagus | ESCC | actin polymerization or depolymerization | 130/8552 | 218/18723 | 2.19e-05 | 1.88e-04 | 130 |
GO:0030041110 | Esophagus | ESCC | actin filament polymerization | 114/8552 | 191/18723 | 6.46e-05 | 4.92e-04 | 114 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0481028 | Esophagus | ESCC | Regulation of actin cytoskeleton | 133/4205 | 229/8465 | 5.94e-03 | 1.48e-02 | 7.56e-03 | 133 |
hsa04810112 | Esophagus | ESCC | Regulation of actin cytoskeleton | 133/4205 | 229/8465 | 5.94e-03 | 1.48e-02 | 7.56e-03 | 133 |
hsa0481021 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
hsa0481031 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
hsa0481041 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0481051 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0481043 | Oral cavity | NEOLP | Regulation of actin cytoskeleton | 55/1112 | 229/8465 | 4.12e-06 | 3.86e-05 | 2.42e-05 | 55 |
hsa0481053 | Oral cavity | NEOLP | Regulation of actin cytoskeleton | 55/1112 | 229/8465 | 4.12e-06 | 3.86e-05 | 2.42e-05 | 55 |
hsa0481020 | Prostate | BPH | Regulation of actin cytoskeleton | 80/1718 | 229/8465 | 1.23e-07 | 1.31e-06 | 8.10e-07 | 80 |
hsa04810110 | Prostate | BPH | Regulation of actin cytoskeleton | 80/1718 | 229/8465 | 1.23e-07 | 1.31e-06 | 8.10e-07 | 80 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABI2 | SNV | Missense_Mutation | novel | c.655N>T | p.Arg219Cys | p.R219C | protein_coding | deleterious(0) | possibly_damaging(0.83) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ABI2 | SNV | Missense_Mutation | novel | c.1455C>G | p.Asp485Glu | p.D485E | protein_coding | tolerated(0.12) | possibly_damaging(0.447) | TCGA-HD-7229-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD | |
ABI2 | SNV | Missense_Mutation | rs761629843 | c.1519N>C | p.Ser507Pro | p.S507P | protein_coding | tolerated(0.13) | probably_damaging(0.941) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ABI2 | SNV | Missense_Mutation | c.595C>T | p.Arg199Cys | p.R199C | protein_coding | deleterious(0) | possibly_damaging(0.881) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
ABI2 | SNV | Missense_Mutation | c.547N>G | p.Ser183Gly | p.S183G | protein_coding | deleterious(0) | probably_damaging(0.916) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
ABI2 | SNV | Missense_Mutation | c.1102N>A | p.Ser368Thr | p.S368T | protein_coding | tolerated_low_confidence(0.24) | probably_damaging(0.986) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | ||
ABI2 | deletion | Frame_Shift_Del | novel | c.44delG | p.Gly15AlafsTer33 | p.G15Afs*33 | protein_coding | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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