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Gene: AATF |
Gene summary for AATF |
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Gene information | Species | Human | Gene symbol | AATF | Gene ID | 26574 |
Gene name | apoptosis antagonizing transcription factor | |
Gene Alias | BFR2 | |
Cytomap | 17q12 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | Q9NY61 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26574 | AATF | LZE2T | Human | Esophagus | ESCC | 1.89e-03 | 1.05e+00 | 0.082 |
26574 | AATF | LZE4T | Human | Esophagus | ESCC | 3.84e-10 | 4.91e-01 | 0.0811 |
26574 | AATF | LZE7T | Human | Esophagus | ESCC | 4.21e-06 | 6.33e-01 | 0.0667 |
26574 | AATF | LZE8T | Human | Esophagus | ESCC | 1.77e-05 | 3.55e-01 | 0.067 |
26574 | AATF | LZE20T | Human | Esophagus | ESCC | 1.06e-02 | 1.55e-01 | 0.0662 |
26574 | AATF | LZE22T | Human | Esophagus | ESCC | 2.39e-08 | 6.61e-01 | 0.068 |
26574 | AATF | LZE24T | Human | Esophagus | ESCC | 4.61e-27 | 8.76e-01 | 0.0596 |
26574 | AATF | LZE21T | Human | Esophagus | ESCC | 1.74e-07 | 6.26e-01 | 0.0655 |
26574 | AATF | LZE6T | Human | Esophagus | ESCC | 1.00e-05 | 4.87e-01 | 0.0845 |
26574 | AATF | P1T-E | Human | Esophagus | ESCC | 1.99e-06 | 4.83e-01 | 0.0875 |
26574 | AATF | P2T-E | Human | Esophagus | ESCC | 6.16e-37 | 6.35e-01 | 0.1177 |
26574 | AATF | P4T-E | Human | Esophagus | ESCC | 1.77e-35 | 9.78e-01 | 0.1323 |
26574 | AATF | P5T-E | Human | Esophagus | ESCC | 7.17e-29 | 6.17e-01 | 0.1327 |
26574 | AATF | P8T-E | Human | Esophagus | ESCC | 2.34e-35 | 5.74e-01 | 0.0889 |
26574 | AATF | P9T-E | Human | Esophagus | ESCC | 1.04e-27 | 6.62e-01 | 0.1131 |
26574 | AATF | P10T-E | Human | Esophagus | ESCC | 1.14e-17 | 2.57e-01 | 0.116 |
26574 | AATF | P11T-E | Human | Esophagus | ESCC | 4.08e-18 | 8.40e-01 | 0.1426 |
26574 | AATF | P12T-E | Human | Esophagus | ESCC | 1.31e-55 | 1.02e+00 | 0.1122 |
26574 | AATF | P15T-E | Human | Esophagus | ESCC | 2.70e-27 | 6.88e-01 | 0.1149 |
26574 | AATF | P16T-E | Human | Esophagus | ESCC | 1.24e-33 | 6.19e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:2001234111 | Esophagus | ESCC | negative regulation of apoptotic signaling pathway | 161/8552 | 224/18723 | 1.24e-15 | 8.09e-14 | 161 |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:200037718 | Esophagus | ESCC | regulation of reactive oxygen species metabolic process | 100/8552 | 157/18723 | 3.87e-06 | 4.17e-05 | 100 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:007259318 | Esophagus | ESCC | reactive oxygen species metabolic process | 137/8552 | 239/18723 | 1.82e-04 | 1.16e-03 | 137 |
GO:20003783 | Esophagus | ESCC | negative regulation of reactive oxygen species metabolic process | 34/8552 | 52/18723 | 3.26e-03 | 1.35e-02 | 34 |
GO:00226137 | Liver | NAFLD | ribonucleoprotein complex biogenesis | 76/1882 | 463/18723 | 1.19e-05 | 3.67e-04 | 76 |
GO:00422547 | Liver | NAFLD | ribosome biogenesis | 52/1882 | 299/18723 | 6.03e-05 | 1.32e-03 | 52 |
GO:20012337 | Liver | NAFLD | regulation of apoptotic signaling pathway | 57/1882 | 356/18723 | 2.73e-04 | 4.41e-03 | 57 |
GO:20003777 | Liver | NAFLD | regulation of reactive oxygen species metabolic process | 28/1882 | 157/18723 | 1.91e-03 | 1.93e-02 | 28 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:200123322 | Liver | HCC | regulation of apoptotic signaling pathway | 226/7958 | 356/18723 | 7.26e-16 | 5.68e-14 | 226 |
GO:200123412 | Liver | HCC | negative regulation of apoptotic signaling pathway | 145/7958 | 224/18723 | 1.33e-11 | 5.36e-10 | 145 |
GO:000734611 | Liver | HCC | regulation of mitotic cell cycle | 255/7958 | 457/18723 | 4.96e-09 | 1.30e-07 | 255 |
GO:200037722 | Liver | HCC | regulation of reactive oxygen species metabolic process | 92/7958 | 157/18723 | 3.34e-05 | 3.35e-04 | 92 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AATF | SNV | Missense_Mutation | novel | c.299N>G | p.Asp100Gly | p.D100G | Q9NY61 | protein_coding | deleterious(0.01) | benign(0.255) | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
AATF | SNV | Missense_Mutation | novel | c.1215N>T | p.Arg405Ser | p.R405S | Q9NY61 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
AATF | SNV | Missense_Mutation | novel | c.803N>A | p.Gly268Asp | p.G268D | Q9NY61 | protein_coding | tolerated(0.11) | possibly_damaging(0.478) | TCGA-44-2656-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
AATF | SNV | Missense_Mutation | novel | c.337N>T | p.Gly113Cys | p.G113C | Q9NY61 | protein_coding | deleterious(0) | benign(0.007) | TCGA-86-6851-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AATF | SNV | Missense_Mutation | novel | c.838A>G | p.Lys280Glu | p.K280E | Q9NY61 | protein_coding | deleterious(0.01) | benign(0.349) | TCGA-63-5131-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
AATF | SNV | Missense_Mutation | novel | c.616N>T | p.Asp206Tyr | p.D206Y | Q9NY61 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-63-A5ML-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | vinorelbine | SD |
AATF | SNV | Missense_Mutation | novel | c.1625N>T | p.Glu542Val | p.E542V | Q9NY61 | protein_coding | deleterious(0.04) | possibly_damaging(0.791) | TCGA-77-8144-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AATF | SNV | Missense_Mutation | rs761448475 | c.1336N>A | p.Ala446Thr | p.A446T | Q9NY61 | protein_coding | tolerated(0.09) | benign(0.226) | TCGA-96-7545-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
AATF | insertion | Frame_Shift_Ins | novel | c.1512dupA | p.Val505SerfsTer3 | p.V505Sfs*3 | Q9NY61 | protein_coding | TCGA-53-7813-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
AATF | insertion | Frame_Shift_Ins | novel | c.1506_1507insA | p.Val505SerfsTer3 | p.V505Sfs*3 | Q9NY61 | protein_coding | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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