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Gene: DNAH7 |
Gene summary for DNAH7 |
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Gene information | Species | Human | Gene symbol | DNAH7 | Gene ID | 56171 |
Gene name | dynein axonemal heavy chain 7 | |
Gene Alias | DNAH7 | |
Cytomap | 2q32.3 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8WXX0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56171 | DNAH7 | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 1.04e-04 | 7.24e-01 | -0.0238 |
56171 | DNAH7 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 9.90e-04 | 6.78e-01 | -0.0296 |
56171 | DNAH7 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 3.02e-07 | 8.38e-01 | -0.0263 |
56171 | DNAH7 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 7.80e-05 | 2.45e-01 | -0.0132 |
56171 | DNAH7 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 8.99e-07 | 2.59e-01 | -0.013 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0060271 | Lung | IAC | cilium assembly | 55/2061 | 337/18723 | 1.84e-03 | 1.88e-02 | 55 |
GO:0044782 | Lung | IAC | cilium organization | 58/2061 | 368/18723 | 3.15e-03 | 2.75e-02 | 58 |
GO:00602711 | Lung | MIAC | cilium assembly | 37/967 | 337/18723 | 1.29e-05 | 9.85e-04 | 37 |
GO:00447821 | Lung | MIAC | cilium organization | 38/967 | 368/18723 | 3.93e-05 | 2.08e-03 | 38 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04814 | Lung | MIAC | Motor proteins | 21/507 | 193/8465 | 5.64e-03 | 3.82e-02 | 2.76e-02 | 21 |
hsa048141 | Lung | MIAC | Motor proteins | 21/507 | 193/8465 | 5.64e-03 | 3.82e-02 | 2.76e-02 | 21 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNAH7 | SNV | Missense_Mutation | c.218N>T | p.Glu73Val | p.E73V | Q8WXX0 | protein_coding | tolerated_low_confidence(0.06) | benign(0.034) | TCGA-CC-A7IH-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
DNAH7 | SNV | Missense_Mutation | c.2789T>C | p.Leu930Ser | p.L930S | Q8WXX0 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-DD-A1EE-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
DNAH7 | SNV | Missense_Mutation | c.607N>G | p.Ile203Val | p.I203V | Q8WXX0 | protein_coding | tolerated(0.2) | benign(0.01) | TCGA-DD-A4NN-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
DNAH7 | SNV | Missense_Mutation | novel | c.11690N>A | p.Thr3897Lys | p.T3897K | Q8WXX0 | protein_coding | tolerated(0.36) | benign(0.085) | TCGA-DD-AACB-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNAH7 | SNV | Missense_Mutation | novel | c.5719N>A | p.Phe1907Ile | p.F1907I | Q8WXX0 | protein_coding | tolerated(0.27) | benign(0.001) | TCGA-DD-AACK-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DNAH7 | SNV | Missense_Mutation | rs769961852 | c.11293N>A | p.Asp3765Asn | p.D3765N | Q8WXX0 | protein_coding | tolerated(0.17) | possibly_damaging(0.787) | TCGA-DD-AACU-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DNAH7 | SNV | Missense_Mutation | novel | c.354N>A | p.His118Gln | p.H118Q | Q8WXX0 | protein_coding | tolerated(0.52) | benign(0) | TCGA-DD-AACU-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DNAH7 | SNV | Missense_Mutation | novel | c.4012N>T | p.Thr1338Ser | p.T1338S | Q8WXX0 | protein_coding | tolerated(0.07) | probably_damaging(0.977) | TCGA-DD-AADO-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DNAH7 | SNV | Missense_Mutation | c.4430N>A | p.Leu1477Gln | p.L1477Q | Q8WXX0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-ED-A7PZ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DNAH7 | SNV | Missense_Mutation | c.577N>A | p.Pro193Thr | p.P193T | Q8WXX0 | protein_coding | deleterious(0.01) | benign(0.037) | TCGA-ED-A7XP-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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