|
Gene: PLEC |
Gene summary for PLEC |
Gene summary. |
Gene information | Species | Human | Gene symbol | PLEC | Gene ID | 5339 |
Gene name | plectin | |
Gene Alias | EBS1 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q15149 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5339 | PLEC | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.08e-04 | 1.89e-01 | 0.0155 |
5339 | PLEC | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.71e-29 | 1.45e+00 | -0.1808 |
5339 | PLEC | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.33e-10 | 6.94e-01 | -0.0811 |
5339 | PLEC | HTA11_78_2000001011 | Human | Colorectum | AD | 4.24e-03 | 3.71e-01 | -0.1088 |
5339 | PLEC | HTA11_347_2000001011 | Human | Colorectum | AD | 5.76e-22 | 6.54e-01 | -0.1954 |
5339 | PLEC | HTA11_411_2000001011 | Human | Colorectum | SER | 2.24e-08 | 1.69e+00 | -0.2602 |
5339 | PLEC | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.17e-06 | 1.25e+00 | -0.2196 |
5339 | PLEC | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.56e-09 | 7.41e-01 | -0.1207 |
5339 | PLEC | HTA11_696_2000001011 | Human | Colorectum | AD | 3.82e-13 | 6.87e-01 | -0.1464 |
5339 | PLEC | HTA11_866_2000001011 | Human | Colorectum | AD | 1.92e-05 | 3.40e-01 | -0.1001 |
5339 | PLEC | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.86e-09 | 6.64e-01 | -0.059 |
5339 | PLEC | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.26e-02 | 4.57e-01 | -0.2061 |
5339 | PLEC | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.41e-02 | 4.13e-01 | 0.0528 |
5339 | PLEC | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.76e-02 | 6.26e-01 | -0.0177 |
5339 | PLEC | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.02e-10 | 4.81e-01 | 0.0674 |
5339 | PLEC | HTA11_7469_2000001011 | Human | Colorectum | AD | 6.23e-06 | 6.30e-01 | -0.0124 |
5339 | PLEC | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.36e-15 | 7.26e-01 | 0.3859 |
5339 | PLEC | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.10e-10 | 4.77e-01 | 0.3005 |
5339 | PLEC | A015-C-203 | Human | Colorectum | FAP | 5.95e-04 | 1.32e-01 | -0.1294 |
5339 | PLEC | A015-C-104 | Human | Colorectum | FAP | 9.51e-05 | 1.01e-01 | -0.1899 |
Page: 1 2 3 4 5 6 7 8 9 10 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0045333 | Colorectum | AD | cellular respiration | 119/3918 | 230/18723 | 3.21e-25 | 4.02e-22 | 119 |
GO:0015980 | Colorectum | AD | energy derivation by oxidation of organic compounds | 143/3918 | 318/18723 | 2.78e-22 | 2.49e-19 | 143 |
GO:0022900 | Colorectum | AD | electron transport chain | 89/3918 | 175/18723 | 1.42e-18 | 8.91e-16 | 89 |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0022904 | Colorectum | AD | respiratory electron transport chain | 63/3918 | 114/18723 | 8.23e-16 | 2.45e-13 | 63 |
GO:0002064 | Colorectum | AD | epithelial cell development | 89/3918 | 220/18723 | 2.98e-11 | 3.52e-09 | 89 |
GO:0045216 | Colorectum | AD | cell-cell junction organization | 80/3918 | 200/18723 | 5.57e-10 | 4.58e-08 | 80 |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0150115 | Colorectum | AD | cell-substrate junction organization | 44/3918 | 101/18723 | 2.38e-07 | 9.81e-06 | 44 |
GO:0062197 | Colorectum | AD | cellular response to chemical stress | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0007044 | Colorectum | AD | cell-substrate junction assembly | 41/3918 | 95/18723 | 8.20e-07 | 2.85e-05 | 41 |
GO:0042060 | Colorectum | AD | wound healing | 128/3918 | 422/18723 | 2.73e-06 | 7.89e-05 | 128 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:0010563 | Colorectum | AD | negative regulation of phosphorus metabolic process | 130/3918 | 442/18723 | 1.26e-05 | 2.76e-04 | 130 |
GO:0045936 | Colorectum | AD | negative regulation of phosphate metabolic process | 129/3918 | 441/18723 | 1.81e-05 | 3.76e-04 | 129 |
GO:0051348 | Colorectum | AD | negative regulation of transferase activity | 85/3918 | 268/18723 | 2.07e-05 | 4.19e-04 | 85 |
GO:0001667 | Colorectum | AD | ameboidal-type cell migration | 137/3918 | 475/18723 | 2.17e-05 | 4.33e-04 | 137 |
GO:0031532 | Colorectum | AD | actin cytoskeleton reorganization | 41/3918 | 107/18723 | 2.81e-05 | 5.28e-04 | 41 |
GO:0120193 | Colorectum | AD | tight junction organization | 33/3918 | 80/18723 | 2.93e-05 | 5.42e-04 | 33 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLEC | SNV | Missense_Mutation | rs782365536 | c.4039N>T | p.Arg1347Cys | p.R1347C | Q15149 | protein_coding | deleterious(0.02) | possibly_damaging(0.759) | TCGA-KK-A59V-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
PLEC | SNV | Missense_Mutation | rs782161008 | c.8477G>A | p.Arg2826His | p.R2826H | Q15149 | protein_coding | tolerated(0.14) | benign(0.001) | TCGA-QU-A6IP-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 6 | Unknown | Unknown | SD |
PLEC | SNV | Missense_Mutation | rs782348944 | c.13498C>T | p.Arg4500Cys | p.R4500C | Q15149 | protein_coding | tolerated(0.05) | probably_damaging(0.959) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PLEC | SNV | Missense_Mutation | rs782648152 | c.679C>T | p.Arg227Trp | p.R227W | Q15149 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PLEC | insertion | Frame_Shift_Ins | novel | c.12304_12305insTA | p.Glu4102ValfsTer20 | p.E4102Vfs*20 | Q15149 | protein_coding | TCGA-XK-AAJT-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD | ||
PLEC | SNV | Missense_Mutation | c.11068N>C | p.Glu3690Gln | p.E3690Q | Q15149 | protein_coding | tolerated(0.07) | benign(0.276) | TCGA-BR-4357-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
PLEC | SNV | Missense_Mutation | rs781927659 | c.8387A>G | p.Gln2796Arg | p.Q2796R | Q15149 | protein_coding | tolerated(0.35) | benign(0) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLEC | SNV | Missense_Mutation | novel | c.7561C>T | p.Arg2521Cys | p.R2521C | Q15149 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.642) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLEC | SNV | Missense_Mutation | c.13259T>C | p.Ile4420Thr | p.I4420T | Q15149 | protein_coding | deleterious(0) | benign(0.366) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLEC | SNV | Missense_Mutation | c.13055A>G | p.Asp4352Gly | p.D4352G | Q15149 | protein_coding | deleterious(0.01) | possibly_damaging(0.877) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |