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Gene: MKI67 |
Gene summary for MKI67 |
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Gene information | Species | Human | Gene symbol | MKI67 | Gene ID | 4288 |
Gene name | marker of proliferation Ki-67 | |
Gene Alias | KIA | |
Cytomap | 10q26.2 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | P46013 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4288 | MKI67 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 2.32e-07 | 3.43e-01 | 0.0208 |
4288 | MKI67 | N_HPV_2 | Human | Cervix | N_HPV | 3.84e-02 | 2.11e-01 | -0.0131 |
4288 | MKI67 | CCI_2 | Human | Cervix | CC | 1.05e-23 | 1.81e+00 | 0.5249 |
4288 | MKI67 | CCI_3 | Human | Cervix | CC | 8.85e-06 | 7.65e-01 | 0.516 |
4288 | MKI67 | sample1 | Human | Cervix | CC | 8.78e-04 | 4.80e-01 | 0.0959 |
4288 | MKI67 | sample3 | Human | Cervix | CC | 1.57e-05 | 2.51e-01 | 0.1387 |
4288 | MKI67 | T1 | Human | Cervix | CC | 2.74e-07 | 4.53e-01 | 0.0918 |
4288 | MKI67 | T3 | Human | Cervix | CC | 1.09e-06 | 2.64e-01 | 0.1389 |
4288 | MKI67 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.64e-03 | 3.51e-01 | -0.0811 |
4288 | MKI67 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.55e-09 | 4.82e-01 | -0.1464 |
4288 | MKI67 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.24e-11 | 6.15e-01 | -0.059 |
4288 | MKI67 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.10e-03 | 1.70e-01 | 0.294 |
4288 | MKI67 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.61e-02 | 1.63e-01 | 0.3859 |
4288 | MKI67 | A002-C-021 | Human | Colorectum | FAP | 3.85e-03 | 9.68e-02 | 0.1171 |
4288 | MKI67 | LZE2T | Human | Esophagus | ESCC | 1.80e-11 | 1.41e+00 | 0.082 |
4288 | MKI67 | LZE4T | Human | Esophagus | ESCC | 2.37e-02 | 2.08e-01 | 0.0811 |
4288 | MKI67 | LZE20T | Human | Esophagus | ESCC | 4.98e-02 | 2.87e-01 | 0.0662 |
4288 | MKI67 | LZE22T | Human | Esophagus | ESCC | 1.57e-02 | 4.36e-01 | 0.068 |
4288 | MKI67 | LZE21T | Human | Esophagus | ESCC | 1.57e-07 | 5.04e-01 | 0.0655 |
4288 | MKI67 | LZE6T | Human | Esophagus | ESCC | 5.26e-07 | 7.36e-01 | 0.0845 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00073466 | Cervix | CC | regulation of mitotic cell cycle | 88/2311 | 457/18723 | 1.26e-05 | 2.60e-04 | 88 |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:01400143 | Cervix | CC | mitotic nuclear division | 50/2311 | 287/18723 | 7.27e-03 | 3.91e-02 | 50 |
GO:00482851 | Cervix | CC | organelle fission | 78/2311 | 488/18723 | 9.70e-03 | 4.79e-02 | 78 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0007346 | Colorectum | AD | regulation of mitotic cell cycle | 119/3918 | 457/18723 | 4.60e-03 | 3.14e-02 | 119 |
GO:0140014 | Colorectum | AD | mitotic nuclear division | 78/3918 | 287/18723 | 6.48e-03 | 4.05e-02 | 78 |
GO:00063252 | Colorectum | MSS | chromatin organization | 107/3467 | 409/18723 | 7.22e-05 | 1.21e-03 | 107 |
GO:00073461 | Colorectum | MSS | regulation of mitotic cell cycle | 108/3467 | 457/18723 | 3.30e-03 | 2.50e-02 | 108 |
GO:01400141 | Colorectum | MSS | mitotic nuclear division | 70/3467 | 287/18723 | 7.48e-03 | 4.72e-02 | 70 |
GO:00063253 | Colorectum | FAP | chromatin organization | 84/2622 | 409/18723 | 1.62e-04 | 2.47e-03 | 84 |
GO:00073462 | Colorectum | FAP | regulation of mitotic cell cycle | 85/2622 | 457/18723 | 3.41e-03 | 2.48e-02 | 85 |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:00519833 | Esophagus | ESCC | regulation of chromosome segregation | 67/8552 | 91/18723 | 5.42e-08 | 9.66e-07 | 67 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00070883 | Esophagus | ESCC | regulation of mitotic nuclear division | 78/8552 | 110/18723 | 6.96e-08 | 1.21e-06 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MKI67 | deletion | Frame_Shift_Del | novel | c.3605_3620delNNNNNNNNNNNNNNNN | p.Gly1202AlafsTer15 | p.G1202Afs*15 | P46013 | protein_coding | TCGA-44-7661-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
MKI67 | insertion | Frame_Shift_Ins | novel | c.1499_1500insAGTA | p.Leu501ValfsTer16 | p.L501Vfs*16 | P46013 | protein_coding | TCGA-55-A4DG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
MKI67 | insertion | In_Frame_Ins | novel | c.1498_1499insTTGTGT | p.Pro500delinsLeuValSer | p.P500delinsLVS | P46013 | protein_coding | TCGA-55-A4DG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
MKI67 | insertion | Frame_Shift_Ins | novel | c.2861_2862insTT | p.Trp954CysfsTer12 | p.W954Cfs*12 | P46013 | protein_coding | TCGA-62-A46V-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MKI67 | insertion | Frame_Shift_Ins | novel | c.5937_5938insAACGCTTTGATGCTCTTTCCATC | p.Ser1980AsnfsTer35 | p.S1980Nfs*35 | P46013 | protein_coding | TCGA-86-A4D0-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR | ||
MKI67 | insertion | Frame_Shift_Ins | novel | c.6311_6312insT | p.Lys2104AsnfsTer50 | p.K2104Nfs*50 | P46013 | protein_coding | TCGA-22-1000-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
MKI67 | insertion | Frame_Shift_Ins | novel | c.2513dupA | p.Asn838LysfsTer25 | p.N838Kfs*25 | P46013 | protein_coding | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | ||
MKI67 | SNV | Missense_Mutation | novel | c.8393N>G | p.Glu2798Gly | p.E2798G | P46013 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-BA-6869-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
MKI67 | SNV | Missense_Mutation | novel | c.2770N>A | p.Glu924Lys | p.E924K | P46013 | protein_coding | deleterious(0.02) | benign(0.354) | TCGA-BB-A5HY-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
MKI67 | SNV | Missense_Mutation | novel | c.8690N>T | p.Asp2897Val | p.D2897V | P46013 | protein_coding | tolerated(0.13) | benign(0.215) | TCGA-CN-4727-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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