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Gene: WDFY3 |
Gene summary for WDFY3 |
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Gene information | Species | Human | Gene symbol | WDFY3 | Gene ID | 23001 |
Gene name | WD repeat and FYVE domain containing 3 | |
Gene Alias | ALFY | |
Cytomap | 4q21.23 | |
Gene Type | protein-coding | GO ID | GO:0006914 | UniProtAcc | A0A024RDI0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23001 | WDFY3 | CCI_1 | Human | Cervix | CC | 3.74e-08 | 9.84e-01 | 0.528 |
23001 | WDFY3 | CCI_3 | Human | Cervix | CC | 3.42e-04 | 5.96e-01 | 0.516 |
23001 | WDFY3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.55e-19 | -5.64e-01 | 0.0155 |
23001 | WDFY3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.88e-07 | -4.74e-01 | -0.1808 |
23001 | WDFY3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.29e-03 | -7.07e-01 | 0.0216 |
23001 | WDFY3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.26e-10 | -6.14e-01 | -0.1207 |
23001 | WDFY3 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.76e-09 | -4.20e-01 | -0.1464 |
23001 | WDFY3 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.12e-03 | -3.43e-01 | -0.1001 |
23001 | WDFY3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.28e-02 | -5.79e-01 | -0.2061 |
23001 | WDFY3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.00e-05 | -8.04e-01 | -0.1462 |
23001 | WDFY3 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.26e-03 | -4.50e-01 | -0.0842 |
23001 | WDFY3 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.54e-14 | -5.19e-01 | 0.096 |
23001 | WDFY3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.66e-03 | -5.51e-01 | 0.0528 |
23001 | WDFY3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.54e-05 | -4.26e-01 | 0.0338 |
23001 | WDFY3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.10e-11 | -4.90e-01 | 0.0674 |
23001 | WDFY3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.96e-02 | -3.00e-01 | 0.0588 |
23001 | WDFY3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.89e-10 | -3.56e-01 | 0.294 |
23001 | WDFY3 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.61e-05 | -5.56e-01 | 0.2585 |
23001 | WDFY3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.18e-16 | -5.68e-01 | 0.3005 |
23001 | WDFY3 | F007 | Human | Colorectum | FAP | 1.63e-02 | -2.13e-01 | 0.1176 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00162367 | Cervix | CC | macroautophagy | 58/2311 | 291/18723 | 1.40e-04 | 1.70e-03 | 58 |
GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
GO:0061912 | Colorectum | AD | selective autophagy | 29/3918 | 68/18723 | 4.20e-05 | 7.39e-04 | 29 |
GO:00162361 | Colorectum | SER | macroautophagy | 79/2897 | 291/18723 | 1.97e-07 | 1.10e-05 | 79 |
GO:00619121 | Colorectum | SER | selective autophagy | 24/2897 | 68/18723 | 4.60e-05 | 1.15e-03 | 24 |
GO:00162362 | Colorectum | MSS | macroautophagy | 93/3467 | 291/18723 | 2.08e-08 | 1.17e-06 | 93 |
GO:00619122 | Colorectum | MSS | selective autophagy | 27/3467 | 68/18723 | 3.68e-05 | 7.09e-04 | 27 |
GO:00162363 | Colorectum | FAP | macroautophagy | 70/2622 | 291/18723 | 2.73e-06 | 1.02e-04 | 70 |
GO:00619123 | Colorectum | FAP | selective autophagy | 19/2622 | 68/18723 | 1.97e-03 | 1.65e-02 | 19 |
GO:00162364 | Colorectum | CRC | macroautophagy | 51/2078 | 291/18723 | 6.40e-04 | 8.48e-03 | 51 |
GO:00162368 | Endometrium | AEH | macroautophagy | 52/2100 | 291/18723 | 4.56e-04 | 4.80e-03 | 52 |
GO:00619125 | Endometrium | AEH | selective autophagy | 17/2100 | 68/18723 | 1.10e-03 | 9.61e-03 | 17 |
GO:001623613 | Endometrium | EEC | macroautophagy | 53/2168 | 291/18723 | 5.40e-04 | 5.42e-03 | 53 |
GO:006191212 | Endometrium | EEC | selective autophagy | 17/2168 | 68/18723 | 1.56e-03 | 1.25e-02 | 17 |
GO:00162365 | Liver | NAFLD | macroautophagy | 45/1882 | 291/18723 | 2.31e-03 | 2.19e-02 | 45 |
GO:001623621 | Liver | HCC | macroautophagy | 204/7958 | 291/18723 | 8.66e-22 | 1.41e-19 | 204 |
GO:006191211 | Liver | HCC | selective autophagy | 49/7958 | 68/18723 | 7.43e-07 | 1.15e-05 | 49 |
GO:00162366 | Lung | IAC | macroautophagy | 51/2061 | 291/18723 | 5.30e-04 | 7.49e-03 | 51 |
GO:001623612 | Lung | AIS | macroautophagy | 46/1849 | 291/18723 | 9.21e-04 | 1.23e-02 | 46 |
GO:00162369 | Prostate | BPH | macroautophagy | 85/3107 | 291/18723 | 4.68e-08 | 1.29e-06 | 85 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDFY3 | SNV | Missense_Mutation | c.3733G>A | p.Val1245Ile | p.V1245I | Q8IZQ1 | protein_coding | tolerated(0.11) | benign(0.018) | TCGA-HJ-7597-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR | |
WDFY3 | SNV | Missense_Mutation | c.5332N>A | p.Ala1778Thr | p.A1778T | Q8IZQ1 | protein_coding | deleterious(0.03) | benign(0.042) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
WDFY3 | SNV | Missense_Mutation | c.3724G>A | p.Val1242Met | p.V1242M | Q8IZQ1 | protein_coding | tolerated(0.12) | benign(0.082) | TCGA-HU-A4H3-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | ts-1 | PD | |
WDFY3 | SNV | Missense_Mutation | c.7175N>G | p.Asn2392Ser | p.N2392S | Q8IZQ1 | protein_coding | tolerated(0.44) | benign(0) | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR | |
WDFY3 | SNV | Missense_Mutation | rs778469198 | c.3928N>T | p.Val1310Leu | p.V1310L | Q8IZQ1 | protein_coding | tolerated(0.71) | benign(0) | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR |
WDFY3 | SNV | Missense_Mutation | c.7837N>A | p.Asp2613Asn | p.D2613N | Q8IZQ1 | protein_coding | deleterious(0) | possibly_damaging(0.558) | TCGA-IN-A6RR-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | unkown | SD | |
WDFY3 | SNV | Missense_Mutation | novel | c.914N>A | p.Arg305Gln | p.R305Q | Q8IZQ1 | protein_coding | deleterious(0.01) | possibly_damaging(0.863) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
WDFY3 | SNV | Missense_Mutation | c.9145N>G | p.Thr3049Ala | p.T3049A | Q8IZQ1 | protein_coding | tolerated(0.18) | benign(0.021) | TCGA-RD-A7C1-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
WDFY3 | SNV | Missense_Mutation | novel | c.10507N>T | p.Val3503Leu | p.V3503L | Q8IZQ1 | protein_coding | deleterious(0.01) | probably_damaging(0.956) | TCGA-VQ-A8PO-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
WDFY3 | SNV | Missense_Mutation | novel | c.1383N>C | p.Lys461Asn | p.K461N | Q8IZQ1 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-VQ-A8PX-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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