![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: FCGBP |
Gene summary for FCGBP |
![]() |
Gene information | Species | Human | Gene symbol | FCGBP | Gene ID | 8857 |
Gene name | Fc fragment of IgG binding protein | |
Gene Alias | FC(GAMMA)BP | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9Y6R7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8857 | FCGBP | CA_HPV_1 | Human | Cervix | CC | 1.45e-10 | -3.40e-01 | 0.0264 |
8857 | FCGBP | CA_HPV_3 | Human | Cervix | CC | 1.97e-03 | -2.60e-01 | 0.0414 |
8857 | FCGBP | CCII_1 | Human | Cervix | CC | 2.57e-02 | -3.24e-01 | 0.3249 |
8857 | FCGBP | Tumor | Human | Cervix | CC | 3.32e-13 | -3.47e-01 | 0.1241 |
8857 | FCGBP | sample1 | Human | Cervix | CC | 3.26e-04 | -3.47e-01 | 0.0959 |
8857 | FCGBP | sample3 | Human | Cervix | CC | 5.98e-15 | -3.47e-01 | 0.1387 |
8857 | FCGBP | H2 | Human | Cervix | HSIL_HPV | 4.45e-30 | 1.05e+00 | 0.0632 |
8857 | FCGBP | L1 | Human | Cervix | CC | 3.14e-06 | -3.47e-01 | 0.0802 |
8857 | FCGBP | T1 | Human | Cervix | CC | 9.73e-12 | -3.47e-01 | 0.0918 |
8857 | FCGBP | T2 | Human | Cervix | CC | 3.15e-03 | 6.82e-01 | 0.0709 |
8857 | FCGBP | T3 | Human | Cervix | CC | 3.60e-12 | -3.47e-01 | 0.1389 |
8857 | FCGBP | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.45e-05 | 4.86e-01 | 0.0155 |
8857 | FCGBP | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.71e-38 | 3.42e+00 | -0.1808 |
8857 | FCGBP | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.75e-28 | 2.65e+00 | -0.0811 |
8857 | FCGBP | HTA11_78_2000001011 | Human | Colorectum | AD | 1.41e-50 | 3.77e+00 | -0.1088 |
8857 | FCGBP | HTA11_347_2000001011 | Human | Colorectum | AD | 5.27e-15 | 2.12e+00 | -0.1954 |
8857 | FCGBP | HTA11_411_2000001011 | Human | Colorectum | SER | 1.02e-04 | 3.27e+00 | -0.2602 |
8857 | FCGBP | HTA11_2112_2000001011 | Human | Colorectum | SER | 8.15e-18 | 4.87e+00 | -0.2196 |
8857 | FCGBP | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.40e-35 | 3.96e+00 | -0.1207 |
8857 | FCGBP | HTA11_83_2000001011 | Human | Colorectum | SER | 2.96e-17 | 2.69e+00 | -0.1526 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FCGBP | SNV | Missense_Mutation | novel | c.11534N>A | p.Ser3845Asn | p.S3845N | protein_coding | tolerated(0.36) | benign(0.031) | TCGA-99-8032-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FCGBP | SNV | Missense_Mutation | novel | c.8923N>T | p.Val2975Leu | p.V2975L | protein_coding | tolerated(0.16) | benign(0.095) | TCGA-MN-A4N1-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FCGBP | SNV | Missense_Mutation | novel | c.448N>T | p.Gly150Cys | p.G150C | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-NJ-A4YI-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
FCGBP | SNV | Missense_Mutation | novel | c.2807G>T | p.Arg936Leu | p.R936L | protein_coding | deleterious(0.01) | possibly_damaging(0.765) | TCGA-18-3407-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FCGBP | SNV | Missense_Mutation | novel | c.11144N>C | p.Gly3715Ala | p.G3715A | protein_coding | deleterious(0.02) | possibly_damaging(0.453) | TCGA-18-3411-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
FCGBP | SNV | Missense_Mutation | novel | c.7783A>G | p.Asn2595Asp | p.N2595D | protein_coding | deleterious(0.03) | possibly_damaging(0.83) | TCGA-18-4721-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FCGBP | SNV | Missense_Mutation | novel | c.6529N>A | p.Val2177Met | p.V2177M | protein_coding | deleterious(0.03) | possibly_damaging(0.861) | TCGA-21-1070-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
FCGBP | SNV | Missense_Mutation | novel | c.6460N>A | p.Asp2154Asn | p.D2154N | protein_coding | tolerated(0.87) | benign(0.157) | TCGA-22-5491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FCGBP | SNV | Missense_Mutation | novel | c.5278N>A | p.Leu1760Ile | p.L1760I | protein_coding | tolerated(0.13) | benign(0.408) | TCGA-22-5491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FCGBP | SNV | Missense_Mutation | novel | c.8028C>G | p.His2676Gln | p.H2676Q | protein_coding | deleterious(0.03) | possibly_damaging(0.839) | TCGA-33-4583-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |