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Gene: NAV3 |
Gene summary for NAV3 |
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Gene information | Species | Human | Gene symbol | NAV3 | Gene ID | 89795 |
Gene name | neuron navigator 3 | |
Gene Alias | POMFIL1 | |
Cytomap | 12q21.2 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8IVL0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
89795 | NAV3 | HTA12-15-2 | Human | Pancreas | PDAC | 1.28e-15 | 1.02e+00 | 0.2315 |
89795 | NAV3 | HTA12-16-2 | Human | Pancreas | PDAC | 1.71e-02 | 5.18e-01 | 0.0535 |
89795 | NAV3 | HTA12-23-1 | Human | Pancreas | PDAC | 1.06e-18 | 1.37e+00 | 0.3405 |
89795 | NAV3 | HTA12-25-1 | Human | Pancreas | PDAC | 3.74e-18 | 1.12e+00 | 0.313 |
89795 | NAV3 | HTA12-26-1 | Human | Pancreas | PDAC | 2.52e-43 | 1.58e+00 | 0.3728 |
89795 | NAV3 | HTA12-29-1 | Human | Pancreas | PDAC | 1.35e-93 | 1.63e+00 | 0.3722 |
89795 | NAV3 | HTA12-30-1 | Human | Pancreas | PDAC | 3.91e-06 | 1.22e+00 | 0.3671 |
89795 | NAV3 | HTA12-32-1 | Human | Pancreas | PDAC | 1.11e-06 | 1.05e+00 | 0.3624 |
89795 | NAV3 | HTA12-9-3 | Human | Pancreas | PDAC | 3.02e-08 | 9.14e-01 | 0.2045 |
89795 | NAV3 | GSM5252128_BPH327PrGF_Via | Human | Prostate | BPH | 1.12e-04 | 3.62e-01 | -0.1688 |
89795 | NAV3 | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 2.02e-16 | 6.38e-01 | -0.1972 |
89795 | NAV3 | GSM5252136_BPH556PrGA1_Fcol | Human | Prostate | BPH | 5.46e-11 | 5.11e-01 | -0.23 |
89795 | NAV3 | 047563_1562-all-cells | Human | Prostate | BPH | 2.92e-08 | 4.99e-01 | 0.0791 |
89795 | NAV3 | 048752_1579-all-cells | Human | Prostate | BPH | 3.04e-55 | 1.24e+00 | 0.1008 |
89795 | NAV3 | 052095_1628-all-cells | Human | Prostate | BPH | 2.13e-46 | 1.20e+00 | 0.1032 |
89795 | NAV3 | 052097_1595-all-cells | Human | Prostate | BPH | 3.76e-50 | 1.20e+00 | 0.0972 |
89795 | NAV3 | 052099_1652-all-cells | Human | Prostate | BPH | 3.78e-66 | 1.36e+00 | 0.1038 |
89795 | NAV3 | Dong_P5 | Human | Prostate | Tumor | 9.61e-03 | -8.09e-02 | 0.053 |
89795 | NAV3 | ATC09 | Human | Thyroid | ATC | 2.95e-02 | 1.47e-01 | 0.2871 |
89795 | NAV3 | ATC12 | Human | Thyroid | ATC | 1.19e-10 | 2.40e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190290318 | Prostate | BPH | regulation of supramolecular fiber organization | 133/3107 | 383/18723 | 2.40e-18 | 8.73e-16 | 133 |
GO:190290518 | Prostate | BPH | positive regulation of supramolecular fiber organization | 84/3107 | 209/18723 | 3.00e-16 | 5.63e-14 | 84 |
GO:004325418 | Prostate | BPH | regulation of protein-containing complex assembly | 133/3107 | 428/18723 | 5.40e-14 | 6.08e-12 | 133 |
GO:005149516 | Prostate | BPH | positive regulation of cytoskeleton organization | 83/3107 | 226/18723 | 1.83e-13 | 1.86e-11 | 83 |
GO:003133418 | Prostate | BPH | positive regulation of protein-containing complex assembly | 84/3107 | 237/18723 | 1.24e-12 | 1.04e-10 | 84 |
GO:003227317 | Prostate | BPH | positive regulation of protein polymerization | 57/3107 | 138/18723 | 4.64e-12 | 3.68e-10 | 57 |
GO:005125818 | Prostate | BPH | protein polymerization | 96/3107 | 297/18723 | 1.52e-11 | 1.10e-09 | 96 |
GO:003227118 | Prostate | BPH | regulation of protein polymerization | 80/3107 | 233/18723 | 2.67e-11 | 1.78e-09 | 80 |
GO:002241117 | Prostate | BPH | cellular component disassembly | 121/3107 | 443/18723 | 6.34e-09 | 2.25e-07 | 121 |
GO:190290410 | Prostate | BPH | negative regulation of supramolecular fiber organization | 55/3107 | 167/18723 | 1.60e-07 | 3.63e-06 | 55 |
GO:00705076 | Prostate | BPH | regulation of microtubule cytoskeleton organization | 48/3107 | 148/18723 | 1.57e-06 | 2.67e-05 | 48 |
GO:00329849 | Prostate | BPH | protein-containing complex disassembly | 65/3107 | 224/18723 | 2.19e-06 | 3.60e-05 | 65 |
GO:00512715 | Prostate | BPH | negative regulation of cellular component movement | 94/3107 | 367/18723 | 6.18e-06 | 9.00e-05 | 94 |
GO:005149410 | Prostate | BPH | negative regulation of cytoskeleton organization | 49/3107 | 163/18723 | 1.32e-05 | 1.74e-04 | 49 |
GO:20001465 | Prostate | BPH | negative regulation of cell motility | 91/3107 | 359/18723 | 1.34e-05 | 1.76e-04 | 91 |
GO:00311166 | Prostate | BPH | positive regulation of microtubule polymerization | 16/3107 | 33/18723 | 2.15e-05 | 2.60e-04 | 16 |
GO:00400135 | Prostate | BPH | negative regulation of locomotion | 96/3107 | 391/18723 | 3.11e-05 | 3.54e-04 | 96 |
GO:001063916 | Prostate | BPH | negative regulation of organelle organization | 87/3107 | 348/18723 | 3.56e-05 | 3.90e-04 | 87 |
GO:00303365 | Prostate | BPH | negative regulation of cell migration | 86/3107 | 344/18723 | 3.93e-05 | 4.25e-04 | 86 |
GO:00328862 | Prostate | BPH | regulation of microtubule-based process | 64/3107 | 240/18723 | 4.93e-05 | 5.11e-04 | 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NAV3 | SNV | Missense_Mutation | c.1568N>T | p.Ser523Phe | p.S523F | Q8IVL0 | protein_coding | deleterious(0.01) | benign(0.416) | TCGA-78-7220-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
NAV3 | SNV | Missense_Mutation | c.2120N>T | p.Gln707Leu | p.Q707L | Q8IVL0 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-78-7220-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
NAV3 | SNV | Missense_Mutation | c.2527N>C | p.Asp843His | p.D843H | Q8IVL0 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-78-7539-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
NAV3 | SNV | Missense_Mutation | novel | c.2392N>A | p.Gln798Lys | p.Q798K | Q8IVL0 | protein_coding | tolerated(0.26) | benign(0.06) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
NAV3 | SNV | Missense_Mutation | novel | c.4759A>G | p.Thr1587Ala | p.T1587A | Q8IVL0 | protein_coding | tolerated(0.69) | probably_damaging(0.993) | TCGA-86-6851-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NAV3 | SNV | Missense_Mutation | novel | c.6826N>C | p.Gly2276Arg | p.G2276R | Q8IVL0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-86-8056-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NAV3 | SNV | Missense_Mutation | c.5710N>T | p.Ala1904Ser | p.A1904S | Q8IVL0 | protein_coding | tolerated(0.89) | benign(0.003) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NAV3 | SNV | Missense_Mutation | novel | c.683N>T | p.Arg228Ile | p.R228I | Q8IVL0 | protein_coding | deleterious(0) | benign(0.014) | TCGA-86-8673-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
NAV3 | SNV | Missense_Mutation | c.4397C>A | p.Ala1466Asp | p.A1466D | Q8IVL0 | protein_coding | deleterious(0.01) | possibly_damaging(0.818) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD | |
NAV3 | SNV | Missense_Mutation | rs748769258 | c.1178N>G | p.Ala393Gly | p.A393G | Q8IVL0 | protein_coding | deleterious(0.02) | benign(0.185) | TCGA-91-6836-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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