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Gene: FRY |
Gene summary for FRY |
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Gene information | Species | Human | Gene symbol | FRY | Gene ID | 10129 |
Gene name | FRY microtubule binding protein | |
Gene Alias | 13CDNA73 | |
Cytomap | 13q13.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q5TBA9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10129 | FRY | S43 | Human | Liver | Cirrhotic | 1.52e-07 | -1.32e-01 | -0.0187 |
10129 | FRY | HCC1_Meng | Human | Liver | HCC | 1.33e-71 | -2.58e-04 | 0.0246 |
10129 | FRY | HCC2_Meng | Human | Liver | HCC | 6.44e-11 | -1.85e-01 | 0.0107 |
10129 | FRY | cirrhotic2 | Human | Liver | Cirrhotic | 1.86e-03 | -1.39e-01 | 0.0201 |
10129 | FRY | HCC5 | Human | Liver | HCC | 2.63e-02 | 1.35e+00 | 0.4932 |
10129 | FRY | S028 | Human | Liver | HCC | 2.75e-04 | 4.33e-01 | 0.2503 |
10129 | FRY | S029 | Human | Liver | HCC | 1.97e-11 | 7.97e-01 | 0.2581 |
10129 | FRY | TD9 | Human | Lung | IAC | 6.78e-04 | 6.88e-01 | 0.088 |
10129 | FRY | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 1.37e-02 | 5.30e-01 | -0.1408 |
10129 | FRY | RNA-P17T-P17T-4 | Human | Lung | IAC | 1.00e-03 | 4.14e-01 | 0.343 |
10129 | FRY | RNA-P17T-P17T-6 | Human | Lung | IAC | 7.10e-03 | 2.92e-01 | 0.3385 |
10129 | FRY | RNA-P17T-P17T-8 | Human | Lung | IAC | 1.04e-05 | 4.81e-01 | 0.3329 |
10129 | FRY | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.85e-05 | 3.31e-01 | -0.2116 |
10129 | FRY | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 2.23e-02 | 3.37e-01 | -0.1941 |
10129 | FRY | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 2.96e-02 | 5.44e-01 | -0.2107 |
10129 | FRY | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 3.52e-08 | 4.80e-01 | -0.2119 |
10129 | FRY | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 7.65e-04 | 2.00e-01 | -0.0166 |
10129 | FRY | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 3.09e-09 | 3.22e-01 | -0.0132 |
10129 | FRY | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 8.88e-14 | 2.95e-01 | -0.013 |
10129 | FRY | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 2.47e-05 | 2.79e-01 | -0.0121 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0090042 | Liver | Cirrhotic | tubulin deacetylation | 8/4634 | 13/18723 | 5.27e-03 | 2.70e-02 | 8 |
GO:0035601 | Liver | Cirrhotic | protein deacylation | 39/4634 | 112/18723 | 1.08e-02 | 4.75e-02 | 39 |
GO:0098732 | Liver | HCC | macromolecule deacylation | 67/7958 | 116/18723 | 6.46e-04 | 3.99e-03 | 67 |
GO:00356011 | Liver | HCC | protein deacylation | 64/7958 | 112/18723 | 1.23e-03 | 6.83e-03 | 64 |
GO:00900421 | Liver | HCC | tubulin deacetylation | 11/7958 | 13/18723 | 2.38e-03 | 1.16e-02 | 11 |
GO:0090311 | Liver | HCC | regulation of protein deacetylation | 30/7958 | 48/18723 | 4.10e-03 | 1.78e-02 | 30 |
GO:00064761 | Liver | HCC | protein deacetylation | 55/7958 | 101/18723 | 1.01e-02 | 3.79e-02 | 55 |
GO:00064762 | Lung | IAC | protein deacetylation | 25/2061 | 101/18723 | 7.38e-05 | 1.55e-03 | 25 |
GO:00356012 | Lung | IAC | protein deacylation | 25/2061 | 112/18723 | 4.18e-04 | 6.25e-03 | 25 |
GO:00987322 | Lung | IAC | macromolecule deacylation | 25/2061 | 116/18723 | 7.26e-04 | 9.60e-03 | 25 |
GO:00903112 | Lung | IAC | regulation of protein deacetylation | 12/2061 | 48/18723 | 4.87e-03 | 3.77e-02 | 12 |
GO:000647611 | Lung | AIS | protein deacetylation | 23/1849 | 101/18723 | 1.06e-04 | 2.54e-03 | 23 |
GO:003560111 | Lung | AIS | protein deacylation | 23/1849 | 112/18723 | 5.25e-04 | 8.42e-03 | 23 |
GO:00987321 | Lung | AIS | macromolecule deacylation | 23/1849 | 116/18723 | 8.77e-04 | 1.19e-02 | 23 |
GO:00903111 | Lung | AIS | regulation of protein deacetylation | 11/1849 | 48/18723 | 6.14e-03 | 4.98e-02 | 11 |
GO:00356014 | Oral cavity | OSCC | protein deacylation | 74/7305 | 112/18723 | 5.88e-09 | 1.26e-07 | 74 |
GO:00987324 | Oral cavity | OSCC | macromolecule deacylation | 74/7305 | 116/18723 | 5.52e-08 | 1.01e-06 | 74 |
GO:00064764 | Oral cavity | OSCC | protein deacetylation | 66/7305 | 101/18723 | 7.36e-08 | 1.30e-06 | 66 |
GO:00903113 | Oral cavity | OSCC | regulation of protein deacetylation | 30/7305 | 48/18723 | 8.31e-04 | 4.41e-03 | 30 |
GO:000647621 | Oral cavity | EOLP | protein deacetylation | 23/2218 | 101/18723 | 1.42e-03 | 9.65e-03 | 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FRY | SNV | Missense_Mutation | novel | c.5141N>T | p.Arg1714Leu | p.R1714L | Q5TBA9 | protein_coding | deleterious(0.04) | possibly_damaging(0.621) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
FRY | SNV | Missense_Mutation | c.4862N>A | p.Ala1621Asp | p.A1621D | Q5TBA9 | protein_coding | deleterious(0) | possibly_damaging(0.889) | TCGA-CN-6989-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD | |
FRY | SNV | Missense_Mutation | novel | c.8609N>T | p.Asp2870Val | p.D2870V | Q5TBA9 | protein_coding | tolerated(0.28) | benign(0.003) | TCGA-CN-A49A-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
FRY | SNV | Missense_Mutation | novel | c.6434T>A | p.Val2145Asp | p.V2145D | Q5TBA9 | protein_coding | deleterious(0) | probably_damaging(0.912) | TCGA-CN-A63U-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FRY | SNV | Missense_Mutation | c.1327C>A | p.Arg443Ser | p.R443S | Q5TBA9 | protein_coding | deleterious(0) | possibly_damaging(0.799) | TCGA-CQ-6222-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unspecific | SD | ||
FRY | SNV | Missense_Mutation | novel | c.4237T>C | p.Ser1413Pro | p.S1413P | Q5TBA9 | protein_coding | tolerated(0.11) | possibly_damaging(0.718) | TCGA-CQ-7065-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
FRY | SNV | Missense_Mutation | novel | c.103N>A | p.Pro35Thr | p.P35T | Q5TBA9 | protein_coding | tolerated_low_confidence(0.18) | benign(0.001) | TCGA-CR-6474-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unspecific | PD | |
FRY | SNV | Missense_Mutation | c.5452C>A | p.Gln1818Lys | p.Q1818K | Q5TBA9 | protein_coding | tolerated(0.28) | benign(0.029) | TCGA-CR-7380-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD | |
FRY | SNV | Missense_Mutation | novel | c.3035N>G | p.Ala1012Gly | p.A1012G | Q5TBA9 | protein_coding | deleterious(0.04) | probably_damaging(0.909) | TCGA-CR-7404-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | PD |
FRY | SNV | Missense_Mutation | novel | c.6412N>T | p.Ala2138Ser | p.A2138S | Q5TBA9 | protein_coding | tolerated(0.95) | benign(0.039) | TCGA-CV-7254-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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