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Gene: USP34 |
Gene summary for USP34 |
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Gene information | Species | Human | Gene symbol | USP34 | Gene ID | 9736 |
Gene name | ubiquitin specific peptidase 34 | |
Gene Alias | USP34 | |
Cytomap | 2p15 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q70CQ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9736 | USP34 | CA_HPV_1 | Human | Cervix | CC | 4.95e-02 | -5.58e-02 | 0.0264 |
9736 | USP34 | CCI_1 | Human | Cervix | CC | 1.89e-03 | 1.36e+00 | 0.528 |
9736 | USP34 | CCI_2 | Human | Cervix | CC | 5.57e-12 | 1.59e+00 | 0.5249 |
9736 | USP34 | CCI_3 | Human | Cervix | CC | 6.87e-16 | 1.24e+00 | 0.516 |
9736 | USP34 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.89e-11 | -5.44e-01 | 0.0155 |
9736 | USP34 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.35e-04 | -7.23e-01 | 0.0216 |
9736 | USP34 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.15e-03 | 3.33e-01 | -0.1954 |
9736 | USP34 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.13e-02 | -2.69e-01 | -0.1526 |
9736 | USP34 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.35e-03 | -4.18e-01 | -0.0179 |
9736 | USP34 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.83e-11 | -6.28e-01 | 0.096 |
9736 | USP34 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.19e-02 | -6.28e-01 | 0.0528 |
9736 | USP34 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.14e-03 | -4.33e-01 | 0.0338 |
9736 | USP34 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.87e-13 | -5.25e-01 | 0.0674 |
9736 | USP34 | HTA11_7469_2000001011 | Human | Colorectum | AD | 5.74e-05 | -7.54e-01 | -0.0124 |
9736 | USP34 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.05e-05 | -3.26e-01 | 0.3859 |
9736 | USP34 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.24e-03 | -6.04e-01 | 0.2585 |
9736 | USP34 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.26e-07 | -4.02e-01 | 0.3005 |
9736 | USP34 | F007 | Human | Colorectum | FAP | 2.47e-04 | -3.79e-01 | 0.1176 |
9736 | USP34 | A001-C-207 | Human | Colorectum | FAP | 5.76e-05 | -1.82e-01 | 0.1278 |
9736 | USP34 | A015-C-203 | Human | Colorectum | FAP | 1.81e-36 | -4.60e-01 | -0.1294 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:00301117 | Cervix | CC | regulation of Wnt signaling pathway | 76/2311 | 328/18723 | 3.05e-08 | 2.08e-06 | 76 |
GO:00608287 | Cervix | CC | regulation of canonical Wnt signaling pathway | 58/2311 | 253/18723 | 1.83e-06 | 5.89e-05 | 58 |
GO:00600707 | Cervix | CC | canonical Wnt signaling pathway | 66/2311 | 303/18723 | 2.47e-06 | 7.35e-05 | 66 |
GO:00301776 | Cervix | CC | positive regulation of Wnt signaling pathway | 31/2311 | 140/18723 | 8.01e-04 | 7.02e-03 | 31 |
GO:00711083 | Cervix | CC | protein K48-linked deubiquitination | 10/2311 | 35/18723 | 7.99e-03 | 4.18e-02 | 10 |
GO:00902636 | Cervix | CC | positive regulation of canonical Wnt signaling pathway | 22/2311 | 106/18723 | 9.52e-03 | 4.72e-02 | 22 |
GO:0030111 | Colorectum | AD | regulation of Wnt signaling pathway | 102/3918 | 328/18723 | 8.51e-06 | 2.03e-04 | 102 |
GO:0016055 | Colorectum | AD | Wnt signaling pathway | 130/3918 | 444/18723 | 1.60e-05 | 3.37e-04 | 130 |
GO:0198738 | Colorectum | AD | cell-cell signaling by wnt | 130/3918 | 446/18723 | 2.02e-05 | 4.10e-04 | 130 |
GO:0060070 | Colorectum | AD | canonical Wnt signaling pathway | 90/3918 | 303/18723 | 1.76e-04 | 2.38e-03 | 90 |
GO:0060828 | Colorectum | AD | regulation of canonical Wnt signaling pathway | 77/3918 | 253/18723 | 2.19e-04 | 2.87e-03 | 77 |
GO:0030177 | Colorectum | AD | positive regulation of Wnt signaling pathway | 45/3918 | 140/18723 | 1.23e-03 | 1.09e-02 | 45 |
GO:00160551 | Colorectum | SER | Wnt signaling pathway | 97/2897 | 444/18723 | 2.02e-04 | 3.68e-03 | 97 |
GO:01987381 | Colorectum | SER | cell-cell signaling by wnt | 97/2897 | 446/18723 | 2.39e-04 | 4.11e-03 | 97 |
GO:00301111 | Colorectum | SER | regulation of Wnt signaling pathway | 75/2897 | 328/18723 | 2.47e-04 | 4.20e-03 | 75 |
GO:00600701 | Colorectum | SER | canonical Wnt signaling pathway | 66/2897 | 303/18723 | 2.10e-03 | 2.06e-02 | 66 |
GO:00608281 | Colorectum | SER | regulation of canonical Wnt signaling pathway | 56/2897 | 253/18723 | 3.03e-03 | 2.67e-02 | 56 |
GO:0090263 | Colorectum | SER | positive regulation of canonical Wnt signaling pathway | 27/2897 | 106/18723 | 5.12e-03 | 3.92e-02 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP34 | SNV | Missense_Mutation | novel | c.6996N>C | p.Leu2332Phe | p.L2332F | Q70CQ2 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-O2-A52S-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
USP34 | deletion | Frame_Shift_Del | c.327_330delNNNN | p.Arg109SerfsTer13 | p.R109Sfs*13 | Q70CQ2 | protein_coding | TCGA-44-3398-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
USP34 | deletion | Frame_Shift_Del | novel | c.10398delT | p.Glu3467SerfsTer14 | p.E3467Sfs*14 | Q70CQ2 | protein_coding | TCGA-64-1681-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Targeted Molecular therapy | tarceva | PD | ||
USP34 | deletion | Frame_Shift_Del | novel | c.421_422delNN | p.Lys141GlufsTer3 | p.K141Efs*3 | Q70CQ2 | protein_coding | TCGA-95-7562-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD | ||
USP34 | deletion | Frame_Shift_Del | novel | c.238_241delNNNN | p.Gln80PhefsTer10 | p.Q80Ffs*10 | Q70CQ2 | protein_coding | TCGA-56-A4ZK-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
USP34 | deletion | Frame_Shift_Del | novel | c.9937delN | p.Ile3313PhefsTer8 | p.I3313Ffs*8 | Q70CQ2 | protein_coding | TCGA-92-7341-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
USP34 | deletion | Frame_Shift_Del | novel | c.9817_9818delNN | p.Gln3273ValfsTer2 | p.Q3273Vfs*2 | Q70CQ2 | protein_coding | TCGA-98-A53A-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
USP34 | SNV | Missense_Mutation | novel | c.8009N>A | p.Arg2670Gln | p.R2670Q | Q70CQ2 | protein_coding | tolerated(0.35) | probably_damaging(0.921) | TCGA-BA-5558-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
USP34 | SNV | Missense_Mutation | novel | c.1273N>G | p.Ile425Val | p.I425V | Q70CQ2 | protein_coding | tolerated(0.85) | possibly_damaging(0.558) | TCGA-BA-A6DA-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
USP34 | SNV | Missense_Mutation | novel | c.8611C>G | p.Gln2871Glu | p.Q2871E | Q70CQ2 | protein_coding | deleterious(0) | possibly_damaging(0.68) | TCGA-BA-A6DI-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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