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Gene: SRRM2 |
Gene summary for SRRM2 |
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Gene information | Species | Human | Gene symbol | SRRM2 | Gene ID | 23524 |
Gene name | serine/arginine repetitive matrix 2 | |
Gene Alias | 300-KD | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | A0A140VK53 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23524 | SRRM2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.22e-05 | 4.32e-01 | -0.1954 |
23524 | SRRM2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.03e-04 | 5.59e-01 | -0.059 |
23524 | SRRM2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.64e-05 | 5.60e-01 | 0.281 |
23524 | SRRM2 | F007 | Human | Colorectum | FAP | 8.63e-07 | 1.90e-01 | 0.1176 |
23524 | SRRM2 | A001-C-207 | Human | Colorectum | FAP | 3.20e-04 | 1.51e-01 | 0.1278 |
23524 | SRRM2 | A015-C-203 | Human | Colorectum | FAP | 6.02e-51 | 4.75e-01 | -0.1294 |
23524 | SRRM2 | A015-C-204 | Human | Colorectum | FAP | 5.43e-16 | 4.24e-01 | -0.0228 |
23524 | SRRM2 | A014-C-040 | Human | Colorectum | FAP | 5.42e-10 | 2.94e-01 | -0.1184 |
23524 | SRRM2 | A002-C-201 | Human | Colorectum | FAP | 1.83e-32 | 4.83e-01 | 0.0324 |
23524 | SRRM2 | A002-C-203 | Human | Colorectum | FAP | 2.16e-05 | 1.55e-01 | 0.2786 |
23524 | SRRM2 | A001-C-119 | Human | Colorectum | FAP | 9.84e-47 | 8.02e-01 | -0.1557 |
23524 | SRRM2 | A001-C-108 | Human | Colorectum | FAP | 4.03e-38 | 5.53e-01 | -0.0272 |
23524 | SRRM2 | A002-C-021 | Human | Colorectum | FAP | 2.48e-15 | 4.26e-01 | 0.1171 |
23524 | SRRM2 | A002-C-205 | Human | Colorectum | FAP | 2.47e-55 | 6.03e-01 | -0.1236 |
23524 | SRRM2 | A014-C-108 | Human | Colorectum | FAP | 1.91e-19 | 6.36e-01 | -0.124 |
23524 | SRRM2 | A001-C-104 | Human | Colorectum | FAP | 1.15e-21 | 4.85e-01 | 0.0184 |
23524 | SRRM2 | A015-C-005 | Human | Colorectum | FAP | 2.86e-11 | 3.62e-01 | -0.0336 |
23524 | SRRM2 | A015-C-006 | Human | Colorectum | FAP | 1.82e-35 | 5.38e-01 | -0.0994 |
23524 | SRRM2 | A015-C-106 | Human | Colorectum | FAP | 5.64e-29 | 5.45e-01 | -0.0511 |
23524 | SRRM2 | A002-C-114 | Human | Colorectum | FAP | 1.17e-47 | 6.32e-01 | -0.1561 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
GO:00003772 | Colorectum | MSS | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003982 | Colorectum | MSS | mRNA splicing, via spliceosome | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003752 | Colorectum | MSS | RNA splicing, via transesterification reactions | 122/3467 | 324/18723 | 2.75e-16 | 8.58e-14 | 122 |
GO:00083804 | Colorectum | FAP | RNA splicing | 108/2622 | 434/18723 | 7.90e-10 | 1.86e-07 | 108 |
GO:00003754 | Colorectum | FAP | RNA splicing, via transesterification reactions | 84/2622 | 324/18723 | 8.06e-09 | 1.10e-06 | 84 |
GO:00003774 | Colorectum | FAP | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 83/2622 | 320/18723 | 9.66e-09 | 1.23e-06 | 83 |
GO:00003984 | Colorectum | FAP | mRNA splicing, via spliceosome | 83/2622 | 320/18723 | 9.66e-09 | 1.23e-06 | 83 |
GO:00083805 | Colorectum | CRC | RNA splicing | 90/2078 | 434/18723 | 2.80e-09 | 7.97e-07 | 90 |
GO:00003775 | Colorectum | CRC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 66/2078 | 320/18723 | 4.39e-07 | 3.37e-05 | 66 |
GO:00003985 | Colorectum | CRC | mRNA splicing, via spliceosome | 66/2078 | 320/18723 | 4.39e-07 | 3.37e-05 | 66 |
GO:00003755 | Colorectum | CRC | RNA splicing, via transesterification reactions | 66/2078 | 324/18723 | 7.00e-07 | 4.61e-05 | 66 |
GO:000838016 | Endometrium | AEH | RNA splicing | 111/2100 | 434/18723 | 2.42e-17 | 1.12e-14 | 111 |
GO:000037515 | Endometrium | AEH | RNA splicing, via transesterification reactions | 88/2100 | 324/18723 | 1.11e-15 | 3.91e-13 | 88 |
GO:000037715 | Endometrium | AEH | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 87/2100 | 320/18723 | 1.51e-15 | 4.78e-13 | 87 |
GO:000039815 | Endometrium | AEH | mRNA splicing, via spliceosome | 87/2100 | 320/18723 | 1.51e-15 | 4.78e-13 | 87 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SRRM2 | SNV | Missense_Mutation | c.369N>T | p.Gln123His | p.Q123H | Q9UQ35 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.984) | TCGA-EM-A3O9-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SRRM2 | SNV | Missense_Mutation | novel | c.4715C>A | p.Pro1572Gln | p.P1572Q | Q9UQ35 | protein_coding | deleterious_low_confidence(0) | benign(0.403) | TCGA-FE-A22Z-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SRRM2 | insertion | Nonsense_Mutation | novel | c.589_590insTCTAAAAAAATA | p.Gly197delinsValTerLysAsnArg | p.G197delinsV*KNR | Q9UQ35 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
SRRM2 | deletion | Frame_Shift_Del | novel | c.3865delN | p.Ser1289HisfsTer8 | p.S1289Hfs*8 | Q9UQ35 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
SRRM2 | insertion | Frame_Shift_Ins | novel | c.3044_3045insCT | p.Cys1016TyrfsTer11 | p.C1016Yfs*11 | Q9UQ35 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
SRRM2 | insertion | Frame_Shift_Ins | novel | c.3045_3046insCTAGGACT | p.Cys1016LeufsTer13 | p.C1016Lfs*13 | Q9UQ35 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
SRRM2 | insertion | Frame_Shift_Ins | novel | c.3300_3301insGCAAC | p.Ser1101AlafsTer16 | p.S1101Afs*16 | Q9UQ35 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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