![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF804A |
Gene summary for ZNF804A |
![]() |
Gene information | Species | Human | Gene symbol | ZNF804A | Gene ID | 91752 |
Gene name | zinc finger protein 804A | |
Gene Alias | C2orf10 | |
Cytomap | 2q32.1 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q7Z570 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91752 | ZNF804A | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.00e-03 | 1.58e-01 | -0.0811 |
91752 | ZNF804A | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.30e-17 | 9.15e-01 | 0.0131 |
91752 | ZNF804A | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.64e-05 | 4.38e-01 | 0.0171 |
91752 | ZNF804A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.07e-04 | 1.20e-01 | 0.294 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010975 | Colorectum | AD | regulation of neuron projection development | 129/3918 | 445/18723 | 2.88e-05 | 5.37e-04 | 129 |
GO:0106027 | Colorectum | AD | neuron projection organization | 36/3918 | 93/18723 | 6.58e-05 | 1.07e-03 | 36 |
GO:0031346 | Colorectum | AD | positive regulation of cell projection organization | 104/3918 | 353/18723 | 8.26e-05 | 1.30e-03 | 104 |
GO:0043954 | Colorectum | AD | cellular component maintenance | 26/3918 | 61/18723 | 1.04e-04 | 1.56e-03 | 26 |
GO:0097061 | Colorectum | AD | dendritic spine organization | 31/3918 | 84/18723 | 5.48e-04 | 5.83e-03 | 31 |
GO:0099173 | Colorectum | AD | postsynapse organization | 51/3918 | 168/18723 | 2.47e-03 | 1.90e-02 | 51 |
GO:0050808 | Colorectum | AD | synapse organization | 112/3918 | 426/18723 | 4.25e-03 | 2.92e-02 | 112 |
GO:0050807 | Colorectum | AD | regulation of synapse organization | 60/3918 | 211/18723 | 5.67e-03 | 3.64e-02 | 60 |
GO:0097062 | Colorectum | AD | dendritic spine maintenance | 10/3918 | 21/18723 | 5.71e-03 | 3.64e-02 | 10 |
GO:01060271 | Colorectum | SER | neuron projection organization | 33/2897 | 93/18723 | 1.64e-06 | 7.23e-05 | 33 |
GO:00970611 | Colorectum | SER | dendritic spine organization | 29/2897 | 84/18723 | 1.27e-05 | 4.01e-04 | 29 |
GO:00991731 | Colorectum | SER | postsynapse organization | 46/2897 | 168/18723 | 5.20e-05 | 1.25e-03 | 46 |
GO:00439541 | Colorectum | SER | cellular component maintenance | 22/2897 | 61/18723 | 6.47e-05 | 1.49e-03 | 22 |
GO:00109751 | Colorectum | SER | regulation of neuron projection development | 92/2897 | 445/18723 | 1.85e-03 | 1.89e-02 | 92 |
GO:00313461 | Colorectum | SER | positive regulation of cell projection organization | 75/2897 | 353/18723 | 2.22e-03 | 2.14e-02 | 75 |
GO:00970621 | Colorectum | SER | dendritic spine maintenance | 9/2897 | 21/18723 | 2.50e-03 | 2.33e-02 | 9 |
GO:00508081 | Colorectum | SER | synapse organization | 85/2897 | 426/18723 | 7.17e-03 | 4.99e-02 | 85 |
GO:01060272 | Colorectum | MSS | neuron projection organization | 34/3467 | 93/18723 | 3.04e-05 | 6.14e-04 | 34 |
GO:00313462 | Colorectum | MSS | positive regulation of cell projection organization | 96/3467 | 353/18723 | 3.44e-05 | 6.70e-04 | 96 |
GO:00109752 | Colorectum | MSS | regulation of neuron projection development | 115/3467 | 445/18723 | 6.91e-05 | 1.20e-03 | 115 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF804A | SNV | Missense_Mutation | novel | c.2101A>G | p.Asn701Asp | p.N701D | Q7Z570 | protein_coding | tolerated(0.37) | benign(0.005) | TCGA-CG-4436-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF804A | SNV | Missense_Mutation | rs377727858 | c.197N>G | p.Tyr66Cys | p.Y66C | Q7Z570 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
ZNF804A | SNV | Missense_Mutation | c.3041N>A | p.Gly1014Asp | p.G1014D | Q7Z570 | protein_coding | deleterious(0.02) | probably_damaging(0.953) | TCGA-D7-5578-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF804A | SNV | Missense_Mutation | c.2487A>C | p.Lys829Asn | p.K829N | Q7Z570 | protein_coding | tolerated(0.09) | benign(0.243) | TCGA-D7-6527-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | |
ZNF804A | SNV | Missense_Mutation | c.3341N>T | p.Ala1114Val | p.A1114V | Q7Z570 | protein_coding | deleterious(0) | benign(0.414) | TCGA-D7-8579-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracilum | CR | |
ZNF804A | SNV | Missense_Mutation | novel | c.2115N>G | p.Asn705Lys | p.N705K | Q7Z570 | protein_coding | tolerated(0.94) | benign(0.005) | TCGA-D7-A6F0-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF804A | SNV | Missense_Mutation | c.2410N>A | p.Ala804Thr | p.A804T | Q7Z570 | protein_coding | tolerated(0.73) | benign(0.015) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
ZNF804A | SNV | Missense_Mutation | novel | c.3286A>C | p.Thr1096Pro | p.T1096P | Q7Z570 | protein_coding | deleterious(0) | possibly_damaging(0.905) | TCGA-R5-A805-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ZNF804A | SNV | Missense_Mutation | c.2434N>T | p.Arg812Trp | p.R812W | Q7Z570 | protein_coding | deleterious(0.03) | benign(0.017) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | ||
ZNF804A | SNV | Missense_Mutation | novel | c.421N>C | p.Thr141Pro | p.T141P | Q7Z570 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VQ-A8PJ-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
91752 | ZNF804A | NA | antipsychotics | 21892778 | ||
91752 | ZNF804A | NA | lithium | LITHIUM | 29121268 |
Page: 1 |