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Gene: ZNF292 |
Gene summary for ZNF292 |
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Gene information | Species | Human | Gene symbol | ZNF292 | Gene ID | 23036 |
Gene name | zinc finger protein 292 | |
Gene Alias | MRD63 | |
Cytomap | 6q14.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O60281 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23036 | ZNF292 | CA_HPV_1 | Human | Cervix | CC | 4.42e-05 | -1.66e-01 | 0.0264 |
23036 | ZNF292 | CCI_1 | Human | Cervix | CC | 2.16e-10 | 1.48e+00 | 0.528 |
23036 | ZNF292 | CCI_2 | Human | Cervix | CC | 3.55e-08 | 9.84e-01 | 0.5249 |
23036 | ZNF292 | CCI_3 | Human | Cervix | CC | 8.69e-04 | 7.01e-01 | 0.516 |
23036 | ZNF292 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.31e-32 | -8.25e-01 | 0.0155 |
23036 | ZNF292 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.93e-07 | -5.31e-01 | -0.1808 |
23036 | ZNF292 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.41e-04 | -8.20e-01 | 0.0216 |
23036 | ZNF292 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.32e-12 | -7.83e-01 | -0.1207 |
23036 | ZNF292 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.39e-04 | -5.18e-01 | -0.1526 |
23036 | ZNF292 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.96e-16 | -4.82e-01 | -0.1464 |
23036 | ZNF292 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.29e-05 | -3.62e-01 | -0.1001 |
23036 | ZNF292 | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.38e-03 | -6.89e-01 | -0.2061 |
23036 | ZNF292 | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.88e-03 | -7.36e-01 | -0.1462 |
23036 | ZNF292 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.99e-03 | -6.20e-01 | -0.0179 |
23036 | ZNF292 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.73e-26 | -7.47e-01 | 0.096 |
23036 | ZNF292 | HTA11_8622_2000001021 | Human | Colorectum | SER | 5.98e-04 | -7.25e-01 | 0.0528 |
23036 | ZNF292 | HTA11_10623_2000001011 | Human | Colorectum | AD | 3.57e-07 | -7.72e-01 | -0.0177 |
23036 | ZNF292 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.45e-06 | -5.65e-01 | 0.0338 |
23036 | ZNF292 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.75e-17 | -6.03e-01 | 0.0674 |
23036 | ZNF292 | HTA11_11156_2000001011 | Human | Colorectum | AD | 1.05e-02 | -8.85e-01 | 0.0397 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF292 | SNV | Missense_Mutation | novel | c.1431N>C | p.Glu477Asp | p.E477D | O60281 | protein_coding | tolerated(0.24) | possibly_damaging(0.493) | TCGA-VQ-A8P5-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | fluorouracil | SD |
ZNF292 | insertion | Frame_Shift_Ins | novel | c.4710dupT | p.Pro1571SerfsTer4 | p.P1571Sfs*4 | O60281 | protein_coding | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF292 | insertion | In_Frame_Ins | novel | c.1534_1535insTCGTTTCAA | p.Gly512delinsValValSerSer | p.G512delinsVVSS | O60281 | protein_coding | TCGA-BR-8485-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
ZNF292 | insertion | Frame_Shift_Ins | novel | c.7626_7627insA | p.Arg2545LysfsTer4 | p.R2545Kfs*4 | O60281 | protein_coding | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
ZNF292 | deletion | Frame_Shift_Del | novel | c.3470delT | p.Leu1157CysfsTer5 | p.L1157Cfs*5 | O60281 | protein_coding | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD | ||
ZNF292 | deletion | Frame_Shift_Del | novel | c.3465delN | p.Leu1157CysfsTer5 | p.L1157Cfs*5 | O60281 | protein_coding | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR | ||
ZNF292 | SNV | Missense_Mutation | c.1399G>T | p.Val467Leu | p.V467L | O60281 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-EL-A3T1-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF292 | insertion | Frame_Shift_Ins | novel | c.5267_5268insGGTTCAC | p.Lys1757ValfsTer6 | p.K1757Vfs*6 | O60281 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
ZNF292 | insertion | Frame_Shift_Ins | novel | c.1686_1687insGCCCATT | p.His563AlafsTer10 | p.H563Afs*10 | O60281 | protein_coding | TCGA-E8-A436-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF292 | insertion | In_Frame_Ins | novel | c.7795_7796insCTTTTTTTA | p.Leu2599delinsProPhePheIle | p.L2599delinsPFFI | O60281 | protein_coding | TCGA-EL-A3ZM-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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