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Gene: ZDBF2 |
Gene summary for ZDBF2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZDBF2 | Gene ID | 57683 |
Gene name | zinc finger DBF-type containing 2 | |
Gene Alias | Slx9 | |
Cytomap | 2q33.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | N0DVX5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57683 | ZDBF2 | LZE4T | Human | Esophagus | ESCC | 6.44e-07 | 2.97e-01 | 0.0811 |
57683 | ZDBF2 | LZE7T | Human | Esophagus | ESCC | 1.89e-08 | 5.99e-01 | 0.0667 |
57683 | ZDBF2 | P2T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.51e-01 | 0.1177 |
57683 | ZDBF2 | P9T-E | Human | Esophagus | ESCC | 3.65e-03 | 8.10e-02 | 0.1131 |
57683 | ZDBF2 | P10T-E | Human | Esophagus | ESCC | 7.90e-03 | 7.02e-02 | 0.116 |
57683 | ZDBF2 | P16T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.40e-01 | 0.1153 |
57683 | ZDBF2 | P22T-E | Human | Esophagus | ESCC | 4.44e-08 | 1.53e-01 | 0.1236 |
57683 | ZDBF2 | P32T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.03e-01 | 0.1666 |
57683 | ZDBF2 | P37T-E | Human | Esophagus | ESCC | 3.04e-07 | 1.29e-01 | 0.1371 |
57683 | ZDBF2 | P48T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.07e-01 | 0.0959 |
57683 | ZDBF2 | P49T-E | Human | Esophagus | ESCC | 1.22e-03 | 6.53e-01 | 0.1768 |
57683 | ZDBF2 | P56T-E | Human | Esophagus | ESCC | 3.65e-05 | 6.51e-01 | 0.1613 |
57683 | ZDBF2 | P62T-E | Human | Esophagus | ESCC | 2.37e-05 | 9.93e-02 | 0.1302 |
57683 | ZDBF2 | P76T-E | Human | Esophagus | ESCC | 8.40e-04 | 7.63e-02 | 0.1207 |
57683 | ZDBF2 | P79T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.34e-01 | 0.1154 |
57683 | ZDBF2 | P107T-E | Human | Esophagus | ESCC | 1.41e-03 | 1.68e-01 | 0.171 |
57683 | ZDBF2 | P130T-E | Human | Esophagus | ESCC | 9.67e-18 | 3.82e-01 | 0.1676 |
57683 | ZDBF2 | male-WTA | Human | Thyroid | PTC | 9.88e-08 | 6.31e-02 | 0.1037 |
57683 | ZDBF2 | PTC01 | Human | Thyroid | PTC | 1.69e-05 | 3.47e-02 | 0.1899 |
57683 | ZDBF2 | PTC04 | Human | Thyroid | PTC | 1.74e-06 | 1.92e-01 | 0.1927 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZDBF2 | deletion | Frame_Shift_Del | novel | c.1310delN | p.Asp437ValfsTer14 | p.D437Vfs*14 | Q9HCK1 | protein_coding | TCGA-55-8208-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
ZDBF2 | insertion | In_Frame_Ins | novel | c.369_370insCATATTCTAATG | p.Lys123_Ser124insHisIleLeuMet | p.K123_S124insHILM | Q9HCK1 | protein_coding | TCGA-56-8504-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
ZDBF2 | insertion | Frame_Shift_Ins | novel | c.5487dupG | p.Lys1830GlufsTer11 | p.K1830Efs*11 | Q9HCK1 | protein_coding | TCGA-77-7337-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
ZDBF2 | insertion | Frame_Shift_Ins | rs765952396 | c.3273_3274insA | p.Ile1094AsnfsTer14 | p.I1094Nfs*14 | Q9HCK1 | protein_coding | TCGA-90-7769-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
ZDBF2 | SNV | Missense_Mutation | novel | c.6948G>T | p.Gln2316His | p.Q2316H | Q9HCK1 | protein_coding | deleterious(0.03) | benign(0.037) | TCGA-BA-A8YP-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | CR |
ZDBF2 | SNV | Missense_Mutation | novel | c.4705N>C | p.Asp1569His | p.D1569H | Q9HCK1 | protein_coding | tolerated(0.07) | possibly_damaging(0.841) | TCGA-BB-A5HU-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
ZDBF2 | SNV | Missense_Mutation | novel | c.6858G>T | p.Met2286Ile | p.M2286I | Q9HCK1 | protein_coding | tolerated(0.65) | benign(0) | TCGA-CR-7402-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
ZDBF2 | SNV | Missense_Mutation | novel | c.792N>C | p.Met264Ile | p.M264I | Q9HCK1 | protein_coding | tolerated(1) | benign(0) | TCGA-CV-6935-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZDBF2 | SNV | Missense_Mutation | novel | c.218C>A | p.Thr73Asn | p.T73N | Q9HCK1 | protein_coding | tolerated(0.32) | possibly_damaging(0.497) | TCGA-CV-6953-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
ZDBF2 | SNV | Missense_Mutation | novel | c.2629N>T | p.His877Tyr | p.H877Y | Q9HCK1 | protein_coding | tolerated(1) | benign(0) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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