![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SACS |
Gene summary for SACS |
![]() |
Gene information | Species | Human | Gene symbol | SACS | Gene ID | 26278 |
Gene name | sacsin molecular chaperone | |
Gene Alias | ARSACS | |
Cytomap | 13q12.12 | |
Gene Type | protein-coding | GO ID | GO:0006457 | UniProtAcc | Q9NZJ4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26278 | SACS | HCC1_Meng | Human | Liver | HCC | 7.47e-29 | 1.10e-01 | 0.0246 |
26278 | SACS | HCC2_Meng | Human | Liver | HCC | 4.33e-03 | 4.21e-02 | 0.0107 |
26278 | SACS | HCC2 | Human | Liver | HCC | 6.71e-09 | 3.20e+00 | 0.5341 |
26278 | SACS | S014 | Human | Liver | HCC | 1.00e-11 | 3.16e-01 | 0.2254 |
26278 | SACS | S015 | Human | Liver | HCC | 3.44e-11 | 3.64e-01 | 0.2375 |
26278 | SACS | S016 | Human | Liver | HCC | 1.03e-10 | 3.19e-01 | 0.2243 |
26278 | SACS | S027 | Human | Liver | HCC | 7.22e-04 | 2.69e-01 | 0.2446 |
26278 | SACS | S028 | Human | Liver | HCC | 1.80e-19 | 5.96e-01 | 0.2503 |
26278 | SACS | S029 | Human | Liver | HCC | 8.63e-16 | 5.78e-01 | 0.2581 |
26278 | SACS | ATC09 | Human | Thyroid | ATC | 1.87e-07 | 2.07e-01 | 0.2871 |
26278 | SACS | ATC11 | Human | Thyroid | ATC | 6.82e-13 | 6.83e-01 | 0.3386 |
26278 | SACS | ATC12 | Human | Thyroid | ATC | 3.68e-03 | 9.04e-02 | 0.34 |
26278 | SACS | ATC13 | Human | Thyroid | ATC | 1.53e-48 | 8.17e-01 | 0.34 |
26278 | SACS | ATC1 | Human | Thyroid | ATC | 8.64e-07 | 2.46e-01 | 0.2878 |
26278 | SACS | ATC2 | Human | Thyroid | ATC | 1.04e-12 | 1.18e+00 | 0.34 |
26278 | SACS | ATC3 | Human | Thyroid | ATC | 8.75e-16 | 7.15e-01 | 0.338 |
26278 | SACS | ATC4 | Human | Thyroid | ATC | 5.04e-05 | 1.25e-01 | 0.34 |
26278 | SACS | ATC5 | Human | Thyroid | ATC | 1.40e-46 | 9.06e-01 | 0.34 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000645712 | Liver | HCC | protein folding | 160/7958 | 212/18723 | 1.07e-22 | 1.88e-20 | 160 |
GO:007084111 | Liver | HCC | inclusion body assembly | 20/7958 | 24/18723 | 4.92e-05 | 4.70e-04 | 20 |
GO:009008311 | Liver | HCC | regulation of inclusion body assembly | 14/7958 | 17/18723 | 9.39e-04 | 5.47e-03 | 14 |
GO:009008411 | Liver | HCC | negative regulation of inclusion body assembly | 9/7958 | 11/18723 | 9.51e-03 | 3.60e-02 | 9 |
GO:000645733 | Thyroid | ATC | protein folding | 140/6293 | 212/18723 | 3.46e-22 | 8.09e-20 | 140 |
GO:009008324 | Thyroid | ATC | regulation of inclusion body assembly | 12/6293 | 17/18723 | 2.02e-03 | 9.60e-03 | 12 |
GO:0070841111 | Thyroid | ATC | inclusion body assembly | 14/6293 | 24/18723 | 1.12e-02 | 4.00e-02 | 14 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SACS | SNV | Missense_Mutation | c.920N>C | p.Leu307Pro | p.L307P | Q9NZJ4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BG-A0M4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
SACS | SNV | Missense_Mutation | rs768517084 | c.6709N>A | p.Glu2237Lys | p.E2237K | Q9NZJ4 | protein_coding | tolerated(0.42) | benign(0.015) | TCGA-BG-A0VX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SACS | SNV | Missense_Mutation | novel | c.5171N>C | p.Leu1724Ser | p.L1724S | Q9NZJ4 | protein_coding | tolerated(0.23) | benign(0) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SACS | SNV | Missense_Mutation | novel | c.7939A>G | p.Ile2647Val | p.I2647V | Q9NZJ4 | protein_coding | tolerated(0.23) | benign(0.046) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SACS | SNV | Missense_Mutation | novel | c.6238G>C | p.Val2080Leu | p.V2080L | Q9NZJ4 | protein_coding | deleterious(0.05) | benign(0) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SACS | SNV | Missense_Mutation | rs867805312 | c.791G>A | p.Gly264Asp | p.G264D | Q9NZJ4 | protein_coding | deleterious(0.04) | benign(0.068) | TCGA-BS-A0TA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD |
SACS | SNV | Missense_Mutation | c.13074A>C | p.Glu4358Asp | p.E4358D | Q9NZJ4 | protein_coding | deleterious(0.01) | probably_damaging(0.978) | TCGA-BS-A0TC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SACS | SNV | Missense_Mutation | c.6466G>T | p.Asp2156Tyr | p.D2156Y | Q9NZJ4 | protein_coding | deleterious(0) | probably_damaging(0.928) | TCGA-BS-A0TC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SACS | SNV | Missense_Mutation | rs748151842 | c.10855N>A | p.Glu3619Lys | p.E3619K | Q9NZJ4 | protein_coding | tolerated(0.07) | benign(0.197) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SACS | SNV | Missense_Mutation | c.7001N>C | p.Lys2334Thr | p.K2334T | Q9NZJ4 | protein_coding | deleterious(0.04) | benign(0.005) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |