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Gene: PCDH11X |
Gene summary for PCDH11X |
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Gene information | Species | Human | Gene symbol | PCDH11X | Gene ID | 27328 |
Gene name | protocadherin 11 X-linked | |
Gene Alias | PCDH-X | |
Cytomap | Xq21.31 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | Q9BZA7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27328 | PCDH11X | p6 | Human | Liver | Cyst | 9.43e-17 | 7.23e-01 | -0.0218 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCDH11X | SNV | Missense_Mutation | novel | c.2744N>G | p.Thr915Arg | p.T915R | Q9BZA7 | protein_coding | tolerated(0.26) | possibly_damaging(0.756) | TCGA-52-7812-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | paclitaxel | PD |
PCDH11X | SNV | Missense_Mutation | rs746951282 | c.3563N>T | p.Arg1188Leu | p.R1188L | Q9BZA7 | protein_coding | deleterious_low_confidence(0.05) | benign(0) | TCGA-56-1622-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
PCDH11X | SNV | Missense_Mutation | c.2229N>G | p.Asp743Glu | p.D743E | Q9BZA7 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-56-6545-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCDH11X | SNV | Missense_Mutation | novel | c.4037N>A | p.Pro1346His | p.P1346H | Q9BZA7 | protein_coding | deleterious_low_confidence(0) | benign(0.048) | TCGA-56-7222-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
PCDH11X | SNV | Missense_Mutation | novel | c.476N>A | p.Thr159Asn | p.T159N | Q9BZA7 | protein_coding | tolerated(0.18) | benign(0.005) | TCGA-56-7730-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
PCDH11X | SNV | Missense_Mutation | novel | c.3856N>T | p.Ala1286Ser | p.A1286S | Q9BZA7 | protein_coding | tolerated_low_confidence(0.34) | benign(0.005) | TCGA-56-8504-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PCDH11X | SNV | Missense_Mutation | novel | c.3811N>A | p.Gln1271Lys | p.Q1271K | Q9BZA7 | protein_coding | tolerated_low_confidence(0.2) | benign(0.015) | TCGA-56-8626-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PCDH11X | SNV | Missense_Mutation | novel | c.2625G>T | p.Lys875Asn | p.K875N | Q9BZA7 | protein_coding | tolerated(0.13) | benign(0.145) | TCGA-58-8390-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PCDH11X | SNV | Missense_Mutation | c.1324G>C | p.Gly442Arg | p.G442R | Q9BZA7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-63-5131-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | SD | |
PCDH11X | SNV | Missense_Mutation | novel | c.544N>G | p.Gln182Glu | p.Q182E | Q9BZA7 | protein_coding | tolerated(0.16) | probably_damaging(0.93) | TCGA-63-7023-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unspecific | Vinorelbine Tartrate | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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