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Gene: ZNF208 |
Gene summary for ZNF208 |
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Gene information | Species | Human | Gene symbol | ZNF208 | Gene ID | 7757 |
Gene name | zinc finger protein 208 | |
Gene Alias | PMIDP | |
Cytomap | 19p12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | M0QYK4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7757 | ZNF208 | HCC1 | Human | Liver | HCC | 2.90e-08 | 2.82e+00 | 0.5336 |
7757 | ZNF208 | HCC2 | Human | Liver | HCC | 2.94e-26 | 3.97e+00 | 0.5341 |
7757 | ZNF208 | male-WTA | Human | Thyroid | PTC | 2.12e-07 | 1.42e-01 | 0.1037 |
7757 | ZNF208 | PTC01 | Human | Thyroid | PTC | 2.09e-04 | 1.40e-01 | 0.1899 |
7757 | ZNF208 | PTC04 | Human | Thyroid | PTC | 1.04e-12 | 2.83e-01 | 0.1927 |
7757 | ZNF208 | PTC05 | Human | Thyroid | PTC | 6.87e-11 | 4.08e-01 | 0.2065 |
7757 | ZNF208 | PTC06 | Human | Thyroid | PTC | 2.67e-27 | 6.23e-01 | 0.2057 |
7757 | ZNF208 | PTC07 | Human | Thyroid | PTC | 1.67e-30 | 4.95e-01 | 0.2044 |
7757 | ZNF208 | ATC13 | Human | Thyroid | ATC | 9.45e-20 | 4.74e-01 | 0.34 |
7757 | ZNF208 | ATC5 | Human | Thyroid | ATC | 3.64e-23 | 5.14e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF208 | END | Thyroid | Healthy | HES5,MIR181A1HG,PIM2, etc. | 2.38e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF208 | SNV | Missense_Mutation | c.277N>A | p.Asp93Asn | p.D93N | O43345 | protein_coding | tolerated(0.16) | benign(0.024) | TCGA-HU-8243-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
ZNF208 | SNV | Missense_Mutation | rs768540069 | c.578N>T | p.Arg193Ile | p.R193I | O43345 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
ZNF208 | SNV | Missense_Mutation | c.578N>C | p.Arg193Thr | p.R193T | O43345 | protein_coding | tolerated(0.12) | benign(0.279) | TCGA-IN-A6RR-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | unkown | SD | |
ZNF208 | SNV | Missense_Mutation | novel | c.2008N>A | p.Cys670Ser | p.C670S | O43345 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-RD-A8N6-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
ZNF208 | SNV | Missense_Mutation | c.2287N>G | p.Thr763Ala | p.T763A | O43345 | protein_coding | tolerated(0.86) | possibly_damaging(0.68) | TCGA-SW-A7EA-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF208 | SNV | Missense_Mutation | novel | c.1051A>G | p.Ser351Gly | p.S351G | O43345 | protein_coding | tolerated(0.12) | benign(0.01) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
ZNF208 | SNV | Missense_Mutation | c.948N>C | p.Lys316Asn | p.K316N | O43345 | protein_coding | tolerated(0.71) | possibly_damaging(0.581) | TCGA-VQ-A8PJ-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
ZNF208 | SNV | Missense_Mutation | novel | c.2891A>C | p.Lys964Thr | p.K964T | O43345 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-VQ-A91Z-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
ZNF208 | SNV | Missense_Mutation | novel | c.3430N>C | p.Glu1144Gln | p.E1144Q | O43345 | protein_coding | tolerated(0.36) | benign(0.32) | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF208 | insertion | In_Frame_Ins | novel | c.747_748insTCTTGCTTATGTAGTTTG | p.Val249_Ile250insSerCysLeuCysSerLeu | p.V249_I250insSCLCSL | O43345 | protein_coding | TCGA-VQ-A8PC-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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