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Gene: UBR4 |
Gene summary for UBR4 |
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Gene information | Species | Human | Gene symbol | UBR4 | Gene ID | 23352 |
Gene name | ubiquitin protein ligase E3 component n-recognin 4 | |
Gene Alias | RBAF600 | |
Cytomap | 1p36.13 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q5T4S7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23352 | UBR4 | LZE2T | Human | Esophagus | ESCC | 1.92e-08 | 9.84e-01 | 0.082 |
23352 | UBR4 | LZE4T | Human | Esophagus | ESCC | 7.62e-10 | 3.29e-01 | 0.0811 |
23352 | UBR4 | LZE5T | Human | Esophagus | ESCC | 2.50e-04 | 3.46e-01 | 0.0514 |
23352 | UBR4 | LZE7T | Human | Esophagus | ESCC | 1.44e-22 | 9.20e-01 | 0.0667 |
23352 | UBR4 | LZE8T | Human | Esophagus | ESCC | 3.29e-09 | 3.89e-01 | 0.067 |
23352 | UBR4 | LZE20T | Human | Esophagus | ESCC | 2.11e-11 | 3.64e-01 | 0.0662 |
23352 | UBR4 | LZE22D1 | Human | Esophagus | HGIN | 7.90e-05 | 2.75e-01 | 0.0595 |
23352 | UBR4 | LZE22T | Human | Esophagus | ESCC | 2.25e-02 | 2.92e-01 | 0.068 |
23352 | UBR4 | LZE24T | Human | Esophagus | ESCC | 2.04e-22 | 5.92e-01 | 0.0596 |
23352 | UBR4 | LZE21T | Human | Esophagus | ESCC | 2.86e-09 | 5.12e-01 | 0.0655 |
23352 | UBR4 | LZE6T | Human | Esophagus | ESCC | 2.51e-05 | 4.35e-01 | 0.0845 |
23352 | UBR4 | P1T-E | Human | Esophagus | ESCC | 3.61e-14 | 6.12e-01 | 0.0875 |
23352 | UBR4 | P2T-E | Human | Esophagus | ESCC | 4.16e-34 | 5.82e-01 | 0.1177 |
23352 | UBR4 | P4T-E | Human | Esophagus | ESCC | 1.10e-10 | 3.36e-01 | 0.1323 |
23352 | UBR4 | P5T-E | Human | Esophagus | ESCC | 6.95e-12 | 2.60e-01 | 0.1327 |
23352 | UBR4 | P8T-E | Human | Esophagus | ESCC | 1.94e-27 | 5.14e-01 | 0.0889 |
23352 | UBR4 | P9T-E | Human | Esophagus | ESCC | 4.02e-18 | 3.86e-01 | 0.1131 |
23352 | UBR4 | P10T-E | Human | Esophagus | ESCC | 3.53e-35 | 6.35e-01 | 0.116 |
23352 | UBR4 | P11T-E | Human | Esophagus | ESCC | 1.28e-17 | 9.84e-01 | 0.1426 |
23352 | UBR4 | P12T-E | Human | Esophagus | ESCC | 1.15e-23 | 4.97e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052039 | Esophagus | HGIN | Viral carcinogenesis | 53/1383 | 204/8465 | 2.58e-04 | 2.71e-03 | 2.15e-03 | 53 |
hsa0520315 | Esophagus | HGIN | Viral carcinogenesis | 53/1383 | 204/8465 | 2.58e-04 | 2.71e-03 | 2.15e-03 | 53 |
hsa0516510 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0520325 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa0516515 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0520335 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa05165 | Liver | Cirrhotic | Human papillomavirus infection | 124/2530 | 331/8465 | 1.55e-03 | 7.83e-03 | 4.83e-03 | 124 |
hsa05203 | Liver | Cirrhotic | Viral carcinogenesis | 76/2530 | 204/8465 | 1.34e-02 | 4.20e-02 | 2.59e-02 | 76 |
hsa051651 | Liver | Cirrhotic | Human papillomavirus infection | 124/2530 | 331/8465 | 1.55e-03 | 7.83e-03 | 4.83e-03 | 124 |
hsa052031 | Liver | Cirrhotic | Viral carcinogenesis | 76/2530 | 204/8465 | 1.34e-02 | 4.20e-02 | 2.59e-02 | 76 |
hsa051652 | Liver | HCC | Human papillomavirus infection | 188/4020 | 331/8465 | 3.34e-04 | 1.49e-03 | 8.29e-04 | 188 |
hsa052032 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa051653 | Liver | HCC | Human papillomavirus infection | 188/4020 | 331/8465 | 3.34e-04 | 1.49e-03 | 8.29e-04 | 188 |
hsa052033 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa051656 | Lung | IAC | Human papillomavirus infection | 71/1053 | 331/8465 | 1.88e-06 | 7.63e-05 | 5.06e-05 | 71 |
hsa052034 | Lung | IAC | Viral carcinogenesis | 43/1053 | 204/8465 | 3.02e-04 | 3.07e-03 | 2.04e-03 | 43 |
hsa0516511 | Lung | IAC | Human papillomavirus infection | 71/1053 | 331/8465 | 1.88e-06 | 7.63e-05 | 5.06e-05 | 71 |
hsa0520311 | Lung | IAC | Viral carcinogenesis | 43/1053 | 204/8465 | 3.02e-04 | 3.07e-03 | 2.04e-03 | 43 |
hsa0516521 | Lung | AIS | Human papillomavirus infection | 64/961 | 331/8465 | 1.03e-05 | 3.04e-04 | 1.95e-04 | 64 |
hsa0520321 | Lung | AIS | Viral carcinogenesis | 37/961 | 204/8465 | 2.49e-03 | 1.49e-02 | 9.55e-03 | 37 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBR4 | SNV | Missense_Mutation | c.6289N>A | p.Glu2097Lys | p.E2097K | Q5T4S7 | protein_coding | tolerated(0.1) | benign(0.074) | TCGA-49-4490-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
UBR4 | SNV | Missense_Mutation | c.535N>T | p.Pro179Ser | p.P179S | Q5T4S7 | protein_coding | tolerated(0.5) | benign(0.017) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UBR4 | SNV | Missense_Mutation | c.1321N>T | p.Ala441Ser | p.A441S | Q5T4S7 | protein_coding | tolerated(0.36) | probably_damaging(0.935) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD | |
UBR4 | SNV | Missense_Mutation | c.7083A>G | p.Ile2361Met | p.I2361M | Q5T4S7 | protein_coding | deleterious(0.01) | benign(0.221) | TCGA-50-5933-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR | |
UBR4 | SNV | Missense_Mutation | novel | c.9937N>A | p.Glu3313Lys | p.E3313K | Q5T4S7 | protein_coding | deleterious(0.01) | probably_damaging(0.931) | TCGA-55-6968-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | unknown | PD |
UBR4 | SNV | Missense_Mutation | novel | c.308N>T | p.Ala103Val | p.A103V | Q5T4S7 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UBR4 | SNV | Missense_Mutation | c.913N>A | p.Asp305Asn | p.D305N | Q5T4S7 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-55-A48Y-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
UBR4 | SNV | Missense_Mutation | c.6801N>T | p.Lys2267Asn | p.K2267N | Q5T4S7 | protein_coding | tolerated(0.07) | probably_damaging(0.966) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
UBR4 | SNV | Missense_Mutation | c.2275N>G | p.Arg759Gly | p.R759G | Q5T4S7 | protein_coding | deleterious(0.01) | probably_damaging(0.931) | TCGA-62-A46V-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UBR4 | SNV | Missense_Mutation | novel | c.5428C>G | p.Leu1810Val | p.L1810V | Q5T4S7 | protein_coding | tolerated(1) | benign(0.003) | TCGA-64-5781-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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