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Gene: LRP1B |
Gene summary for LRP1B |
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Gene information | Species | Human | Gene symbol | LRP1B | Gene ID | 53353 |
Gene name | LDL receptor related protein 1B | |
Gene Alias | LRP-1B | |
Cytomap | 2q22.1-q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9NZR2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
53353 | LRP1B | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.24e-03 | 1.97e-01 | -0.1808 |
53353 | LRP1B | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.94e-02 | 2.72e-01 | -0.2196 |
53353 | LRP1B | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.47e-04 | 1.66e-01 | -0.059 |
53353 | LRP1B | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.38e-02 | 2.49e-01 | 0.0131 |
53353 | LRP1B | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.68e-03 | 3.08e-01 | 0.0112 |
53353 | LRP1B | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.05e-02 | 1.71e-01 | 0.0588 |
53353 | LRP1B | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.07e-05 | 2.74e-01 | 0.281 |
53353 | LRP1B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.19e-17 | 4.84e-01 | 0.3859 |
53353 | LRP1B | NAFLD1 | Human | Liver | NAFLD | 1.31e-03 | 6.31e-01 | -0.04 |
53353 | LRP1B | HCC1_Meng | Human | Liver | HCC | 2.06e-05 | -4.12e-02 | 0.0246 |
53353 | LRP1B | HCC2 | Human | Liver | HCC | 5.93e-03 | 1.50e+00 | 0.5341 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006898 | Colorectum | AD | receptor-mediated endocytosis | 76/3918 | 244/18723 | 1.07e-04 | 1.59e-03 | 76 |
GO:00068981 | Colorectum | MSS | receptor-mediated endocytosis | 69/3467 | 244/18723 | 1.18e-04 | 1.82e-03 | 69 |
GO:00068984 | Liver | NAFLD | receptor-mediated endocytosis | 49/1882 | 244/18723 | 1.80e-06 | 7.78e-05 | 49 |
GO:000689821 | Liver | HCC | receptor-mediated endocytosis | 134/7958 | 244/18723 | 5.73e-05 | 5.31e-04 | 134 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRP1B | SNV | Missense_Mutation | novel | c.5276N>T | p.Arg1759Ile | p.R1759I | Q9NZR2 | protein_coding | deleterious(0.04) | probably_damaging(0.994) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
LRP1B | SNV | Missense_Mutation | rs376573282 | c.4898N>A | p.Ala1633Asp | p.A1633D | Q9NZR2 | protein_coding | deleterious(0) | possibly_damaging(0.767) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
LRP1B | SNV | Missense_Mutation | c.4721N>C | p.Lys1574Thr | p.K1574T | Q9NZR2 | protein_coding | deleterious(0.02) | benign(0.162) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
LRP1B | SNV | Missense_Mutation | c.3815N>T | p.Arg1272Met | p.R1272M | Q9NZR2 | protein_coding | deleterious(0) | possibly_damaging(0.733) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
LRP1B | SNV | Missense_Mutation | novel | c.13487N>C | p.Asn4496Thr | p.N4496T | Q9NZR2 | protein_coding | tolerated(0.1) | benign(0.081) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
LRP1B | SNV | Missense_Mutation | novel | c.7031N>C | p.Ile2344Thr | p.I2344T | Q9NZR2 | protein_coding | deleterious(0) | possibly_damaging(0.666) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
LRP1B | SNV | Missense_Mutation | novel | c.2568N>A | p.His856Gln | p.H856Q | Q9NZR2 | protein_coding | tolerated(0.06) | benign(0.037) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
LRP1B | SNV | Missense_Mutation | novel | c.710N>A | p.Thr237Asn | p.T237N | Q9NZR2 | protein_coding | deleterious(0) | benign(0) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
LRP1B | SNV | Missense_Mutation | c.3895C>A | p.Gln1299Lys | p.Q1299K | Q9NZR2 | protein_coding | tolerated(0.12) | benign(0.057) | TCGA-AX-A06H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD | |
LRP1B | SNV | Missense_Mutation | rs762458785 | c.4840G>A | p.Asp1614Asn | p.D1614N | Q9NZR2 | protein_coding | deleterious(0.02) | possibly_damaging(0.883) | TCGA-AX-A0IU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
53353 | LRP1B | CLINICALLY ACTIONABLE, DRUG RESISTANCE | DOXORUBICIN | DOXORUBICIN | 22896685 |
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