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Gene: TAF1 |
Gene summary for TAF1 |
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Gene information | Species | Human | Gene symbol | TAF1 | Gene ID | 6872 |
Gene name | TATA-box binding protein associated factor 1 | |
Gene Alias | BA2R | |
Cytomap | Xq13.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P21675 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6872 | TAF1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.60e-07 | -5.33e-02 | -0.1869 |
6872 | TAF1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 4.11e-05 | -1.18e-01 | -0.1875 |
6872 | TAF1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 8.31e-10 | -5.23e-02 | -0.1883 |
6872 | TAF1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 4.77e-06 | -3.76e-02 | -0.1934 |
6872 | TAF1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 7.67e-07 | -8.08e-02 | -0.1917 |
6872 | TAF1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 8.00e-09 | -1.10e-01 | -0.1916 |
6872 | TAF1 | LZE4T | Human | Esophagus | ESCC | 7.07e-11 | 3.10e-01 | 0.0811 |
6872 | TAF1 | LZE5T | Human | Esophagus | ESCC | 3.35e-02 | 2.64e-01 | 0.0514 |
6872 | TAF1 | LZE7T | Human | Esophagus | ESCC | 4.05e-10 | 4.91e-01 | 0.0667 |
6872 | TAF1 | LZE8T | Human | Esophagus | ESCC | 1.03e-03 | 1.23e-01 | 0.067 |
6872 | TAF1 | LZE24T | Human | Esophagus | ESCC | 1.02e-18 | 5.28e-01 | 0.0596 |
6872 | TAF1 | LZE21T | Human | Esophagus | ESCC | 4.21e-04 | 1.86e-01 | 0.0655 |
6872 | TAF1 | P1T-E | Human | Esophagus | ESCC | 6.77e-05 | 3.04e-01 | 0.0875 |
6872 | TAF1 | P2T-E | Human | Esophagus | ESCC | 2.30e-15 | 2.99e-01 | 0.1177 |
6872 | TAF1 | P4T-E | Human | Esophagus | ESCC | 9.05e-14 | 2.10e-01 | 0.1323 |
6872 | TAF1 | P5T-E | Human | Esophagus | ESCC | 2.53e-10 | 1.53e-01 | 0.1327 |
6872 | TAF1 | P8T-E | Human | Esophagus | ESCC | 6.06e-24 | 4.42e-01 | 0.0889 |
6872 | TAF1 | P9T-E | Human | Esophagus | ESCC | 2.93e-08 | 1.84e-01 | 0.1131 |
6872 | TAF1 | P10T-E | Human | Esophagus | ESCC | 3.76e-16 | 2.90e-01 | 0.116 |
6872 | TAF1 | P11T-E | Human | Esophagus | ESCC | 4.65e-06 | 2.92e-01 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003133010 | Cervix | CC | negative regulation of cellular catabolic process | 63/2311 | 262/18723 | 1.10e-07 | 5.68e-06 | 63 |
GO:005109810 | Cervix | CC | regulation of binding | 80/2311 | 363/18723 | 1.32e-07 | 6.42e-06 | 80 |
GO:00447725 | Cervix | CC | mitotic cell cycle phase transition | 89/2311 | 424/18723 | 2.70e-07 | 1.12e-05 | 89 |
GO:00064029 | Cervix | CC | mRNA catabolic process | 56/2311 | 232/18723 | 4.81e-07 | 1.83e-05 | 56 |
GO:19033119 | Cervix | CC | regulation of mRNA metabolic process | 64/2311 | 288/18723 | 1.71e-06 | 5.64e-05 | 64 |
GO:000989510 | Cervix | CC | negative regulation of catabolic process | 69/2311 | 320/18723 | 2.15e-06 | 6.55e-05 | 69 |
GO:00064019 | Cervix | CC | RNA catabolic process | 62/2311 | 278/18723 | 2.18e-06 | 6.56e-05 | 62 |
GO:00000824 | Cervix | CC | G1/S transition of mitotic cell cycle | 49/2311 | 214/18723 | 1.16e-05 | 2.48e-04 | 49 |
GO:00448434 | Cervix | CC | cell cycle G1/S phase transition | 53/2311 | 241/18723 | 1.76e-05 | 3.32e-04 | 53 |
GO:004873210 | Cervix | CC | gland development | 84/2311 | 436/18723 | 1.93e-05 | 3.54e-04 | 84 |
GO:005110110 | Cervix | CC | regulation of DNA binding | 31/2311 | 118/18723 | 2.91e-05 | 4.81e-04 | 31 |
GO:00610139 | Cervix | CC | regulation of mRNA catabolic process | 38/2311 | 166/18723 | 1.07e-04 | 1.36e-03 | 38 |
GO:00165705 | Cervix | CC | histone modification | 84/2311 | 463/18723 | 1.70e-04 | 2.01e-03 | 84 |
GO:190331210 | Cervix | CC | negative regulation of mRNA metabolic process | 24/2311 | 92/18723 | 2.49e-04 | 2.77e-03 | 24 |
GO:00610089 | Cervix | CC | hepaticobiliary system development | 34/2311 | 150/18723 | 2.92e-04 | 3.14e-03 | 34 |
GO:00467008 | Cervix | CC | heterocycle catabolic process | 80/2311 | 445/18723 | 3.23e-04 | 3.42e-03 | 80 |
GO:00346559 | Cervix | CC | nucleobase-containing compound catabolic process | 74/2311 | 407/18723 | 3.77e-04 | 3.88e-03 | 74 |
GO:00434889 | Cervix | CC | regulation of mRNA stability | 35/2311 | 158/18723 | 3.80e-04 | 3.89e-03 | 35 |
GO:00018899 | Cervix | CC | liver development | 33/2311 | 147/18723 | 4.27e-04 | 4.30e-03 | 33 |
GO:00434879 | Cervix | CC | regulation of RNA stability | 36/2311 | 170/18723 | 7.72e-04 | 6.86e-03 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030222 | Esophagus | ESCC | Basal transcription factors | 35/4205 | 45/8465 | 1.01e-04 | 4.06e-04 | 2.08e-04 | 35 |
hsa0302211 | Esophagus | ESCC | Basal transcription factors | 35/4205 | 45/8465 | 1.01e-04 | 4.06e-04 | 2.08e-04 | 35 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TAF1 | SNV | Missense_Mutation | c.169G>A | p.Val57Ile | p.V57I | P21675 | protein_coding | tolerated(0.46) | benign(0.012) | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD | |
TAF1 | SNV | Missense_Mutation | c.3719N>G | p.Glu1240Gly | p.E1240G | P21675 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-HU-A4H5-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | doxifluridine | SD | |
TAF1 | SNV | Missense_Mutation | novel | c.4441N>G | p.Asn1481Asp | p.N1481D | P21675 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-IN-A6RO-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | irinotecan | PD |
TAF1 | SNV | Missense_Mutation | c.10N>A | p.Gly4Ser | p.G4S | P21675 | protein_coding | tolerated_low_confidence(0.57) | benign(0) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
TAF1 | SNV | Missense_Mutation | c.1322A>T | p.Asp441Val | p.D441V | P21675 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | |
TAF1 | deletion | Frame_Shift_Del | novel | c.5390delN | p.Asn1798MetfsTer5 | p.N1798Mfs*5 | P21675 | protein_coding | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
TAF1 | SNV | Missense_Mutation | novel | c.1231G>A | p.Glu411Lys | p.E411K | P21675 | protein_coding | tolerated(0.39) | benign(0) | TCGA-KS-A4I7-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Hormone Therapy | levothyroxine | SD |
TAF1 | insertion | Frame_Shift_Ins | novel | c.1813_1814insGC | p.Phe605CysfsTer38 | p.F605Cfs*38 | P21675 | protein_coding | TCGA-DJ-A3VK-01 | Thyroid | thyroid carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | ||
TAF1 | insertion | Frame_Shift_Ins | novel | c.1814_1815insG | p.Phe605LeufsTer94 | p.F605Lfs*94 | P21675 | protein_coding | TCGA-DJ-A3VK-01 | Thyroid | thyroid carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | ||
TAF1 | insertion | Frame_Shift_Ins | novel | c.5513_5514insT | p.Ser1839LysfsTer9 | p.S1839Kfs*9 | P21675 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6872 | TAF1 | TRANSCRIPTION FACTOR COMPLEX, NUCLEAR HORMONE RECEPTOR, KINASE, SERINE THREONINE KINASE, TRANSCRIPTION FACTOR, ENZYME, CLINICALLY ACTIONABLE | inhibitor | 336446910 | ||
6872 | TAF1 | TRANSCRIPTION FACTOR COMPLEX, NUCLEAR HORMONE RECEPTOR, KINASE, SERINE THREONINE KINASE, TRANSCRIPTION FACTOR, ENZYME, CLINICALLY ACTIONABLE | DOXORUBICIN | DOXORUBICIN | 10070062 |
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