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Gene: SCN7A |
Gene summary for SCN7A |
Gene summary. |
Gene information | Species | Human | Gene symbol | SCN7A | Gene ID | 6332 |
Gene name | sodium voltage-gated channel alpha subunit 7 | |
Gene Alias | NaG | |
Cytomap | 2q24.3 | |
Gene Type | protein-coding | GO ID | GO:0001508 | UniProtAcc | Q01118 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6332 | SCN7A | P8T-E | Human | Esophagus | ESCC | 2.12e-03 | 2.57e-01 | 0.0889 |
6332 | SCN7A | P9T-E | Human | Esophagus | ESCC | 8.38e-03 | 1.36e-01 | 0.1131 |
6332 | SCN7A | P11T-E | Human | Esophagus | ESCC | 3.66e-11 | 8.26e-01 | 0.1426 |
6332 | SCN7A | P19T-E | Human | Esophagus | ESCC | 2.95e-08 | 1.09e+00 | 0.1662 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCN7A | insertion | Frame_Shift_Ins | novel | c.4125_4126insCATCCCA | p.Ser1376HisfsTer28 | p.S1376Hfs*28 | Q01118 | protein_coding | TCGA-BR-8485-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
SCN7A | insertion | Frame_Shift_Ins | rs769551067 | c.741_742insT | p.Leu248SerfsTer19 | p.L248Sfs*19 | Q01118 | protein_coding | TCGA-BR-A4PF-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
SCN7A | insertion | Frame_Shift_Ins | novel | c.3199_3200insATTTGCATTTACCTAACAATTGG | p.Met1067AsnfsTer9 | p.M1067Nfs*9 | Q01118 | protein_coding | TCGA-BJ-A18Y-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
SCN7A | insertion | Frame_Shift_Ins | novel | c.2374_2375insCATC | p.Asp792AlafsTer7 | p.D792Afs*7 | Q01118 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
SCN7A | insertion | Frame_Shift_Ins | novel | c.4944_4945insACATTTT | p.Ser1649ThrfsTer11 | p.S1649Tfs*11 | Q01118 | protein_coding | TCGA-EL-A3ZM-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
SCN7A | insertion | Frame_Shift_Ins | novel | c.4631_4632insCATCCTCACA | p.Leu1545IlefsTer5 | p.L1545Ifs*5 | Q01118 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6332 | SCN7A | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL856 | PRIMIDONE | |
6332 | SCN7A | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL1200440 | MEPIVACAINE HYDROCHLORIDE | |
6332 | SCN7A | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL16 | PHENYTOIN | |
6332 | SCN7A | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL1201020 | DISOPYRAMIDE PHOSPHATE | |
6332 | SCN7A | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL1200464 | PROPARACAINE HYDROCHLORIDE | |
6332 | SCN7A | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL1255654 | TETRACAINE HYDROCHLORIDE | |
6332 | SCN7A | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL1200334 | MORICIZINE HYDROCHLORIDE | |
6332 | SCN7A | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL1889140 | ROPIVACAINE HYDROCHLORIDE | |
6332 | SCN7A | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL87992 | ESLICARBAZEPINE ACETATE | |
6332 | SCN7A | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL944 | CHLOROPROCAINE HYDROCHLORIDE |
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