![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PEG3 |
Gene summary for PEG3 |
![]() |
Gene information | Species | Human | Gene symbol | PEG3 | Gene ID | 5178 |
Gene name | paternally expressed 3 | |
Gene Alias | PW1 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9GZU2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5178 | PEG3 | GSM4909281 | Human | Breast | IDC | 1.58e-28 | 5.45e-01 | 0.21 |
5178 | PEG3 | GSM4909298 | Human | Breast | IDC | 4.14e-61 | 8.98e-01 | 0.1551 |
5178 | PEG3 | GSM4909304 | Human | Breast | IDC | 5.34e-07 | 2.18e-01 | 0.1636 |
5178 | PEG3 | HCC1_Meng | Human | Liver | HCC | 8.95e-10 | 4.36e-02 | 0.0246 |
5178 | PEG3 | HCC2 | Human | Liver | HCC | 1.25e-22 | 3.74e+00 | 0.5341 |
5178 | PEG3 | S014 | Human | Liver | HCC | 2.68e-34 | 1.10e+00 | 0.2254 |
5178 | PEG3 | S015 | Human | Liver | HCC | 3.41e-32 | 1.14e+00 | 0.2375 |
5178 | PEG3 | S016 | Human | Liver | HCC | 4.77e-32 | 1.21e+00 | 0.2243 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
PEG3 | PERI | Cervix | HSIL_HPV | AC006115.2,HES6,SERTM1, etc. | 3.67e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PEG3 | SNV | Missense_Mutation | c.580G>T | p.Asp194Tyr | p.D194Y | Q9GZU2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PEG3 | SNV | Missense_Mutation | c.3292C>A | p.Gln1098Lys | p.Q1098K | Q9GZU2 | protein_coding | tolerated(0.07) | benign(0.035) | TCGA-60-2721-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PEG3 | SNV | Missense_Mutation | novel | c.4688A>C | p.Tyr1563Ser | p.Y1563S | Q9GZU2 | protein_coding | tolerated(0.08) | benign(0.01) | TCGA-60-2724-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD |
PEG3 | SNV | Missense_Mutation | novel | c.2031N>T | p.Lys677Asn | p.K677N | Q9GZU2 | protein_coding | deleterious(0.03) | benign(0.031) | TCGA-63-A5MB-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
PEG3 | SNV | Missense_Mutation | novel | c.3098G>A | p.Cys1033Tyr | p.C1033Y | Q9GZU2 | protein_coding | tolerated(0.71) | benign(0) | TCGA-63-A5ML-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | vinorelbine | SD |
PEG3 | SNV | Missense_Mutation | novel | c.256A>G | p.Ile86Val | p.I86V | Q9GZU2 | protein_coding | tolerated(0.27) | benign(0.01) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
PEG3 | SNV | Missense_Mutation | novel | c.3742A>G | p.Arg1248Gly | p.R1248G | Q9GZU2 | protein_coding | tolerated(0.33) | benign(0.057) | TCGA-63-A5MW-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PEG3 | SNV | Missense_Mutation | rs189053356 | c.4638N>G | p.Ile1546Met | p.I1546M | Q9GZU2 | protein_coding | tolerated(0.2) | benign(0.012) | TCGA-66-2756-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
PEG3 | SNV | Missense_Mutation | c.3640G>T | p.Ala1214Ser | p.A1214S | Q9GZU2 | protein_coding | tolerated(0.59) | benign(0.006) | TCGA-66-2767-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
PEG3 | SNV | Missense_Mutation | c.875N>A | p.Met292Lys | p.M292K | Q9GZU2 | protein_coding | deleterious(0) | benign(0.056) | TCGA-66-2777-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |