|
Gene: PCLO |
Gene summary for PCLO |
Gene summary. |
Gene information | Species | Human | Gene symbol | PCLO | Gene ID | 27445 |
Gene name | piccolo presynaptic cytomatrix protein | |
Gene Alias | ACZ | |
Cytomap | 7q21.11 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | Q9Y6V0 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27445 | PCLO | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.61e-04 | -3.06e-01 | 0.0155 |
27445 | PCLO | HTA11_347_2000001011 | Human | Colorectum | AD | 6.10e-07 | 4.87e-01 | -0.1954 |
27445 | PCLO | HTA11_866_3004761011 | Human | Colorectum | AD | 2.93e-04 | -3.55e-01 | 0.096 |
27445 | PCLO | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.37e-02 | -3.55e-01 | 0.0338 |
27445 | PCLO | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.12e-06 | -3.06e-01 | 0.0674 |
27445 | PCLO | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.85e-16 | -4.36e-01 | 0.294 |
27445 | PCLO | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.66e-02 | 5.33e-01 | 0.281 |
27445 | PCLO | A015-C-203 | Human | Colorectum | FAP | 1.60e-09 | -1.04e-01 | -0.1294 |
27445 | PCLO | A002-C-201 | Human | Colorectum | FAP | 7.33e-03 | -9.02e-02 | 0.0324 |
27445 | PCLO | A001-C-108 | Human | Colorectum | FAP | 4.46e-03 | 3.11e-02 | -0.0272 |
27445 | PCLO | A002-C-205 | Human | Colorectum | FAP | 6.02e-07 | 7.51e-02 | -0.1236 |
27445 | PCLO | A015-C-006 | Human | Colorectum | FAP | 1.63e-03 | -2.59e-02 | -0.0994 |
27445 | PCLO | A015-C-106 | Human | Colorectum | FAP | 5.64e-03 | -6.35e-02 | -0.0511 |
27445 | PCLO | A002-C-114 | Human | Colorectum | FAP | 3.97e-04 | -1.29e-01 | -0.1561 |
27445 | PCLO | A015-C-104 | Human | Colorectum | FAP | 4.38e-08 | -6.65e-02 | -0.1899 |
27445 | PCLO | A002-C-016 | Human | Colorectum | FAP | 8.50e-08 | -6.14e-03 | 0.0521 |
27445 | PCLO | A002-C-116 | Human | Colorectum | FAP | 3.76e-09 | -2.58e-01 | -0.0452 |
27445 | PCLO | A014-C-008 | Human | Colorectum | FAP | 1.54e-04 | 1.04e-01 | -0.191 |
27445 | PCLO | A018-E-020 | Human | Colorectum | FAP | 1.00e-04 | -1.28e-01 | -0.2034 |
27445 | PCLO | F034 | Human | Colorectum | FAP | 5.30e-06 | 3.76e-02 | -0.0665 |
Page: 1 2 3 4 5 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0051648 | Colorectum | AD | vesicle localization | 59/3918 | 177/18723 | 7.83e-05 | 1.25e-03 | 59 |
GO:0043954 | Colorectum | AD | cellular component maintenance | 26/3918 | 61/18723 | 1.04e-04 | 1.56e-03 | 26 |
GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
GO:0030073 | Colorectum | AD | insulin secretion | 61/3918 | 195/18723 | 4.28e-04 | 4.81e-03 | 61 |
GO:0015833 | Colorectum | AD | peptide transport | 77/3918 | 264/18723 | 8.90e-04 | 8.60e-03 | 77 |
GO:0030072 | Colorectum | AD | peptide hormone secretion | 68/3918 | 236/18723 | 2.39e-03 | 1.85e-02 | 68 |
GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
GO:0034331 | Colorectum | AD | cell junction maintenance | 15/3918 | 35/18723 | 2.78e-03 | 2.09e-02 | 15 |
GO:0002790 | Colorectum | AD | peptide secretion | 69/3918 | 242/18723 | 2.97e-03 | 2.22e-02 | 69 |
GO:0017157 | Colorectum | AD | regulation of exocytosis | 59/3918 | 202/18723 | 3.20e-03 | 2.36e-02 | 59 |
GO:0042886 | Colorectum | AD | amide transport | 83/3918 | 301/18723 | 3.37e-03 | 2.46e-02 | 83 |
GO:0050808 | Colorectum | AD | synapse organization | 112/3918 | 426/18723 | 4.25e-03 | 2.92e-02 | 112 |
GO:1902414 | Colorectum | AD | protein localization to cell junction | 31/3918 | 94/18723 | 4.30e-03 | 2.95e-02 | 31 |
GO:0099003 | Colorectum | AD | vesicle-mediated transport in synapse | 57/3918 | 200/18723 | 6.53e-03 | 4.06e-02 | 57 |
GO:00343292 | Colorectum | MSS | cell junction assembly | 120/3467 | 420/18723 | 2.51e-07 | 1.07e-05 | 120 |
GO:00093062 | Colorectum | MSS | protein secretion | 98/3467 | 359/18723 | 2.43e-05 | 5.09e-04 | 98 |
GO:00355922 | Colorectum | MSS | establishment of protein localization to extracellular region | 98/3467 | 360/18723 | 2.75e-05 | 5.58e-04 | 98 |
Page: 1 2 3 4 5 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04911 | Colorectum | FAP | Insulin secretion | 23/1404 | 86/8465 | 1.12e-02 | 3.92e-02 | 2.38e-02 | 23 |
hsa049111 | Colorectum | FAP | Insulin secretion | 23/1404 | 86/8465 | 1.12e-02 | 3.92e-02 | 2.38e-02 | 23 |
hsa049112 | Colorectum | CRC | Insulin secretion | 20/1091 | 86/8465 | 5.61e-03 | 2.88e-02 | 1.95e-02 | 20 |
hsa049113 | Colorectum | CRC | Insulin secretion | 20/1091 | 86/8465 | 5.61e-03 | 2.88e-02 | 1.95e-02 | 20 |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCLO | SNV | Missense_Mutation | c.9235N>A | p.Gly3079Arg | p.G3079R | Q9Y6V0 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-B5-A11N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCLO | SNV | Missense_Mutation | novel | c.10613N>A | p.Ser3538Tyr | p.S3538Y | Q9Y6V0 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PCLO | SNV | Missense_Mutation | novel | c.5852N>C | p.Leu1951Pro | p.L1951P | Q9Y6V0 | protein_coding | deleterious(0.02) | possibly_damaging(0.629) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PCLO | SNV | Missense_Mutation | novel | c.4841N>C | p.Lys1614Thr | p.K1614T | Q9Y6V0 | protein_coding | deleterious(0.03) | possibly_damaging(0.893) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PCLO | SNV | Missense_Mutation | rs758203919 | c.4255N>G | p.Ile1419Val | p.I1419V | Q9Y6V0 | protein_coding | deleterious(0.03) | benign(0.082) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PCLO | SNV | Missense_Mutation | c.2691N>T | p.Lys897Asn | p.K897N | Q9Y6V0 | protein_coding | deleterious(0.03) | probably_damaging(0.976) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PCLO | SNV | Missense_Mutation | c.3262A>C | p.Asn1088His | p.N1088H | Q9Y6V0 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-B5-A1MU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxifen | PD | |
PCLO | SNV | Missense_Mutation | novel | c.8612N>A | p.Pro2871His | p.P2871H | Q9Y6V0 | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
PCLO | SNV | Missense_Mutation | novel | c.3882N>T | p.Lys1294Asn | p.K1294N | Q9Y6V0 | protein_coding | deleterious_low_confidence(0.01) | benign(0.013) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
PCLO | SNV | Missense_Mutation | rs372497499 | c.12397N>T | p.Arg4133Cys | p.R4133C | Q9Y6V0 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |