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Gene: FN1 |
Gene summary for FN1 |
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Gene information | Species | Human | Gene symbol | FN1 | Gene ID | 2335 |
Gene name | fibronectin 1 | |
Gene Alias | CIG | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | B7ZLE5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2335 | FN1 | GSM4909281 | Human | Breast | IDC | 1.26e-02 | 2.49e-01 | 0.21 |
2335 | FN1 | GSM4909287 | Human | Breast | IDC | 3.77e-02 | 2.33e-01 | 0.2057 |
2335 | FN1 | GSM4909295 | Human | Breast | IDC | 3.02e-10 | 5.92e-01 | 0.0898 |
2335 | FN1 | GSM4909302 | Human | Breast | IDC | 2.28e-46 | 9.23e-01 | 0.1545 |
2335 | FN1 | GSM4909307 | Human | Breast | IDC | 3.08e-07 | 4.56e-01 | 0.1569 |
2335 | FN1 | GSM4909309 | Human | Breast | IDC | 2.29e-02 | 2.64e-01 | 0.0483 |
2335 | FN1 | GSM4909317 | Human | Breast | IDC | 2.42e-02 | 2.00e-01 | 0.1355 |
2335 | FN1 | M2 | Human | Breast | IDC | 8.50e-08 | 6.55e-01 | 0.21 |
2335 | FN1 | P2 | Human | Breast | IDC | 7.87e-08 | 5.15e-01 | 0.21 |
2335 | FN1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.80e-02 | 1.24e+00 | 0.096 |
2335 | FN1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 7.00e-04 | 1.12e+00 | 0.2585 |
2335 | FN1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.83e-09 | 1.84e+00 | 0.3005 |
2335 | FN1 | F007 | Human | Colorectum | FAP | 1.05e-03 | -2.53e-01 | 0.1176 |
2335 | FN1 | A001-C-207 | Human | Colorectum | FAP | 6.53e-06 | -2.53e-01 | 0.1278 |
2335 | FN1 | A002-C-201 | Human | Colorectum | FAP | 4.40e-09 | -2.53e-01 | 0.0324 |
2335 | FN1 | A002-C-203 | Human | Colorectum | FAP | 2.00e-05 | -2.47e-01 | 0.2786 |
2335 | FN1 | A001-C-119 | Human | Colorectum | FAP | 6.20e-23 | 1.12e+00 | -0.1557 |
2335 | FN1 | A002-C-021 | Human | Colorectum | FAP | 1.07e-02 | 3.83e-01 | 0.1171 |
2335 | FN1 | A002-C-205 | Human | Colorectum | FAP | 8.74e-09 | -2.53e-01 | -0.1236 |
2335 | FN1 | A014-C-108 | Human | Colorectum | FAP | 2.28e-02 | -2.19e-01 | -0.124 |
Page: 1 2 3 4 5 6 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00432549 | Breast | Precancer | regulation of protein-containing complex assembly | 50/1080 | 428/18723 | 1.63e-06 | 5.97e-05 | 50 |
GO:00508219 | Breast | Precancer | protein stabilization | 29/1080 | 191/18723 | 1.67e-06 | 6.08e-05 | 29 |
GO:00313349 | Breast | Precancer | positive regulation of protein-containing complex assembly | 33/1080 | 237/18723 | 2.39e-06 | 8.21e-05 | 33 |
GO:00316479 | Breast | Precancer | regulation of protein stability | 38/1080 | 298/18723 | 3.73e-06 | 1.19e-04 | 38 |
GO:00106348 | Breast | Precancer | positive regulation of epithelial cell migration | 25/1080 | 176/18723 | 2.75e-05 | 6.21e-04 | 25 |
GO:19029059 | Breast | Precancer | positive regulation of supramolecular fiber organization | 28/1080 | 209/18723 | 2.79e-05 | 6.28e-04 | 28 |
GO:00106319 | Breast | Precancer | epithelial cell migration | 40/1080 | 357/18723 | 4.57e-05 | 9.71e-04 | 40 |
GO:19029039 | Breast | Precancer | regulation of supramolecular fiber organization | 42/1080 | 383/18723 | 4.92e-05 | 1.04e-03 | 42 |
GO:00901329 | Breast | Precancer | epithelium migration | 40/1080 | 360/18723 | 5.51e-05 | 1.14e-03 | 40 |
GO:00901309 | Breast | Precancer | tissue migration | 40/1080 | 365/18723 | 7.48e-05 | 1.47e-03 | 40 |
GO:00329709 | Breast | Precancer | regulation of actin filament-based process | 42/1080 | 397/18723 | 1.11e-04 | 2.01e-03 | 42 |
GO:00514959 | Breast | Precancer | positive regulation of cytoskeleton organization | 28/1080 | 226/18723 | 1.13e-04 | 2.04e-03 | 28 |
GO:00106329 | Breast | Precancer | regulation of epithelial cell migration | 33/1080 | 292/18723 | 1.74e-04 | 2.86e-03 | 33 |
GO:00016678 | Breast | Precancer | ameboidal-type cell migration | 47/1080 | 475/18723 | 2.19e-04 | 3.35e-03 | 47 |
GO:00434624 | Breast | Precancer | regulation of ATPase activity | 10/1080 | 46/18723 | 2.38e-04 | 3.57e-03 | 10 |
GO:00070159 | Breast | Precancer | actin filament organization | 44/1080 | 442/18723 | 3.02e-04 | 4.35e-03 | 44 |
GO:00329569 | Breast | Precancer | regulation of actin cytoskeleton organization | 36/1080 | 358/18723 | 8.56e-04 | 9.88e-03 | 36 |
GO:00351486 | Breast | Precancer | tube formation | 19/1080 | 148/18723 | 8.79e-04 | 1.01e-02 | 19 |
GO:00322739 | Breast | Precancer | positive regulation of protein polymerization | 18/1080 | 138/18723 | 9.85e-04 | 1.11e-02 | 18 |
GO:00313338 | Breast | Precancer | negative regulation of protein-containing complex assembly | 18/1080 | 141/18723 | 1.27e-03 | 1.35e-02 | 18 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520523 | Breast | IDC | Proteoglycans in cancer | 42/867 | 205/8465 | 7.69e-06 | 9.99e-05 | 7.48e-05 | 42 |
hsa0510024 | Breast | IDC | Bacterial invasion of epithelial cells | 17/867 | 77/8465 | 1.69e-03 | 1.19e-02 | 8.93e-03 | 17 |
hsa0481014 | Breast | IDC | Regulation of actin cytoskeleton | 36/867 | 229/8465 | 5.79e-03 | 3.13e-02 | 2.34e-02 | 36 |
hsa045109 | Breast | IDC | Focal adhesion | 32/867 | 203/8465 | 8.60e-03 | 4.23e-02 | 3.17e-02 | 32 |
hsa0520533 | Breast | IDC | Proteoglycans in cancer | 42/867 | 205/8465 | 7.69e-06 | 9.99e-05 | 7.48e-05 | 42 |
hsa0510034 | Breast | IDC | Bacterial invasion of epithelial cells | 17/867 | 77/8465 | 1.69e-03 | 1.19e-02 | 8.93e-03 | 17 |
hsa0481015 | Breast | IDC | Regulation of actin cytoskeleton | 36/867 | 229/8465 | 5.79e-03 | 3.13e-02 | 2.34e-02 | 36 |
hsa0451013 | Breast | IDC | Focal adhesion | 32/867 | 203/8465 | 8.60e-03 | 4.23e-02 | 3.17e-02 | 32 |
hsa05205 | Colorectum | AD | Proteoglycans in cancer | 70/2092 | 205/8465 | 1.37e-03 | 8.46e-03 | 5.39e-03 | 70 |
hsa04810 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa04510 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa052051 | Colorectum | AD | Proteoglycans in cancer | 70/2092 | 205/8465 | 1.37e-03 | 8.46e-03 | 5.39e-03 | 70 |
hsa048101 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa045101 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa051004 | Colorectum | MSS | Bacterial invasion of epithelial cells | 36/1875 | 77/8465 | 1.41e-06 | 1.82e-05 | 1.11e-05 | 36 |
hsa051354 | Colorectum | MSS | Yersinia infection | 53/1875 | 137/8465 | 7.73e-06 | 8.93e-05 | 5.47e-05 | 53 |
hsa052054 | Colorectum | MSS | Proteoglycans in cancer | 65/1875 | 205/8465 | 8.66e-04 | 5.38e-03 | 3.29e-03 | 65 |
hsa048104 | Colorectum | MSS | Regulation of actin cytoskeleton | 68/1875 | 229/8465 | 4.27e-03 | 1.86e-02 | 1.14e-02 | 68 |
hsa05222 | Colorectum | MSS | Small cell lung cancer | 30/1875 | 92/8465 | 1.31e-02 | 4.30e-02 | 2.64e-02 | 30 |
hsa051005 | Colorectum | MSS | Bacterial invasion of epithelial cells | 36/1875 | 77/8465 | 1.41e-06 | 1.82e-05 | 1.11e-05 | 36 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
FN1 | ITGA4_ITGB1 | FN1_ITGA4_ITGB1 | FN1 | Breast | ADJ |
FN1 | ITGA5_ITGB1 | FN1_ITGA5_ITGB1 | FN1 | Breast | ADJ |
FN1 | CD44 | FN1_CD44 | FN1 | Breast | ADJ |
FN1 | SDC4 | FN1_SDC4 | FN1 | Breast | ADJ |
FN1 | ITGA4_ITGB1 | FN1_ITGA4_ITGB1 | FN1 | Breast | DCIS |
FN1 | ITGA5_ITGB1 | FN1_ITGA5_ITGB1 | FN1 | Breast | DCIS |
FN1 | ITGAV_ITGB1 | FN1_ITGAV_ITGB1 | FN1 | Breast | DCIS |
FN1 | ITGA4_ITGB7 | FN1_ITGA4_ITGB7 | FN1 | Breast | DCIS |
FN1 | CD44 | FN1_CD44 | FN1 | Breast | DCIS |
FN1 | SDC1 | FN1_SDC1 | FN1 | Breast | DCIS |
FN1 | SDC4 | FN1_SDC4 | FN1 | Breast | DCIS |
FN1 | ITGA4_ITGB1 | FN1_ITGA4_ITGB1 | FN1 | Breast | Healthy |
FN1 | ITGA5_ITGB1 | FN1_ITGA5_ITGB1 | FN1 | Breast | Healthy |
FN1 | ITGAV_ITGB1 | FN1_ITGAV_ITGB1 | FN1 | Breast | Healthy |
FN1 | ITGA4_ITGB7 | FN1_ITGA4_ITGB7 | FN1 | Breast | Healthy |
FN1 | ITGAV_ITGB6 | FN1_ITGAV_ITGB6 | FN1 | Breast | Healthy |
FN1 | ITGAV_ITGB8 | FN1_ITGAV_ITGB8 | FN1 | Breast | Healthy |
FN1 | CD44 | FN1_CD44 | FN1 | Breast | Healthy |
FN1 | SDC1 | FN1_SDC1 | FN1 | Breast | Healthy |
FN1 | SDC4 | FN1_SDC4 | FN1 | Breast | Healthy |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FN1 | SNV | Missense_Mutation | novel | c.3448G>T | p.Val1150Phe | p.V1150F | P02751 | protein_coding | deleterious(0.01) | benign(0.385) | TCGA-KK-A7B0-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Hormone Therapy | leuprolide | SD |
FN1 | SNV | Missense_Mutation | rs775917038 | c.3233N>T | p.Ala1078Val | p.A1078V | P02751 | protein_coding | tolerated(1) | benign(0.011) | TCGA-XQ-A8TB-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
FN1 | SNV | Missense_Mutation | novel | c.5536N>T | p.Arg1846Trp | p.R1846W | P02751 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-ZG-A9LY-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
FN1 | SNV | Missense_Mutation | novel | c.2180C>A | p.Ser727Tyr | p.S727Y | P02751 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-3M-AB47-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
FN1 | SNV | Missense_Mutation | c.4277N>C | p.Val1426Ala | p.V1426A | P02751 | protein_coding | tolerated(0.2) | benign(0.072) | TCGA-BR-4257-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FN1 | SNV | Missense_Mutation | rs375642491 | c.4012N>A | p.Val1338Ile | p.V1338I | P02751 | protein_coding | tolerated(0.17) | probably_damaging(0.956) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FN1 | SNV | Missense_Mutation | c.2626N>C | p.Tyr876His | p.Y876H | P02751 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
FN1 | SNV | Missense_Mutation | c.2197N>A | p.Ala733Thr | p.A733T | P02751 | protein_coding | tolerated(0.08) | benign(0.318) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
FN1 | SNV | Missense_Mutation | c.2510N>T | p.Pro837Leu | p.P837L | P02751 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FN1 | SNV | Missense_Mutation | c.14N>T | p.Pro5Leu | p.P5L | P02751 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2335 | FN1 | DRUGGABLE GENOME | CHEMBL2109608 | L19IL2 | ||
2335 | FN1 | DRUGGABLE GENOME | Ocriplasmin | OCRIPLASMIN | ||
2335 | FN1 | DRUGGABLE GENOME | CHEMBL2095222 | OCRIPLASMIN | ||
2335 | FN1 | DRUGGABLE GENOME | AS1409 | |||
2335 | FN1 | DRUGGABLE GENOME | L19-TNF-alpha | |||
2335 | FN1 | DRUGGABLE GENOME | CHEMBL2109589 | L19TNFA | ||
2335 | FN1 | DRUGGABLE GENOME | CHEMBL2109412 | L19SIP 131I |
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