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Gene: FLG2 |
Gene summary for FLG2 |
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Gene information | Species | Human | Gene symbol | FLG2 | Gene ID | 388698 |
Gene name | filaggrin family member 2 | |
Gene Alias | IFPS | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0002009 | UniProtAcc | Q5D862 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
388698 | FLG2 | HCC1 | Human | Liver | HCC | 1.73e-10 | 1.15e+00 | 0.5336 |
388698 | FLG2 | HCC2 | Human | Liver | HCC | 3.58e-20 | 1.18e+00 | 0.5341 |
388698 | FLG2 | HCC5 | Human | Liver | HCC | 3.79e-21 | 1.18e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005087822 | Liver | HCC | regulation of body fluid levels | 191/7958 | 379/18723 | 1.06e-03 | 6.11e-03 | 191 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FLG2 | SNV | Missense_Mutation | c.2134N>G | p.Ser712Gly | p.S712G | Q5D862 | protein_coding | tolerated_low_confidence(0.83) | benign(0) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FLG2 | SNV | Missense_Mutation | c.886N>C | p.Ser296Arg | p.S296R | Q5D862 | protein_coding | deleterious(0) | possibly_damaging(0.742) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FLG2 | SNV | Missense_Mutation | c.764N>G | p.Gln255Arg | p.Q255R | Q5D862 | protein_coding | tolerated(0.09) | benign(0.333) | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
FLG2 | SNV | Missense_Mutation | c.2629N>T | p.Ser877Cys | p.S877C | Q5D862 | protein_coding | tolerated(0.07) | possibly_damaging(0.468) | TCGA-BR-6457-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Ancillary | leucovorin | CR | |
FLG2 | SNV | Missense_Mutation | c.302N>G | p.Lys101Arg | p.K101R | Q5D862 | protein_coding | deleterious(0.02) | probably_damaging(0.965) | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FLG2 | SNV | Missense_Mutation | novel | c.6529N>G | p.Arg2177Gly | p.R2177G | Q5D862 | protein_coding | tolerated(1) | benign(0.022) | TCGA-BR-7723-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | PD |
FLG2 | SNV | Missense_Mutation | c.172N>G | p.Met58Val | p.M58V | Q5D862 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-BR-7901-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FLG2 | SNV | Missense_Mutation | c.6834A>C | p.Gln2278His | p.Q2278H | Q5D862 | protein_coding | tolerated(0.53) | probably_damaging(0.994) | TCGA-BR-7958-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
FLG2 | SNV | Missense_Mutation | c.2954N>G | p.Ser985Cys | p.S985C | Q5D862 | protein_coding | tolerated(0.07) | possibly_damaging(0.79) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
FLG2 | SNV | Missense_Mutation | c.4025N>C | p.Arg1342Thr | p.R1342T | Q5D862 | protein_coding | deleterious(0.03) | possibly_damaging(0.878) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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