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Gene: ANKRD30A |
Gene summary for ANKRD30A |
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Gene information | Species | Human | Gene symbol | ANKRD30A | Gene ID | 91074 |
Gene name | ankyrin repeat domain 30A | |
Gene Alias | NY-BR-1 | |
Cytomap | 10p11.21 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q9BXX3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91074 | ANKRD30A | GSM4909281 | Human | Breast | IDC | 5.35e-20 | -5.37e-01 | 0.21 |
91074 | ANKRD30A | GSM4909282 | Human | Breast | IDC | 9.92e-21 | -5.37e-01 | -0.0288 |
91074 | ANKRD30A | GSM4909285 | Human | Breast | IDC | 1.31e-17 | -5.25e-01 | 0.21 |
91074 | ANKRD30A | GSM4909286 | Human | Breast | IDC | 2.86e-19 | -5.36e-01 | 0.1081 |
91074 | ANKRD30A | GSM4909287 | Human | Breast | IDC | 4.02e-18 | -5.37e-01 | 0.2057 |
91074 | ANKRD30A | GSM4909288 | Human | Breast | IDC | 8.02e-04 | -5.37e-01 | 0.0988 |
91074 | ANKRD30A | GSM4909293 | Human | Breast | IDC | 4.72e-37 | 5.30e-01 | 0.1581 |
91074 | ANKRD30A | GSM4909294 | Human | Breast | IDC | 9.04e-07 | 5.32e-01 | 0.2022 |
91074 | ANKRD30A | GSM4909295 | Human | Breast | IDC | 5.68e-08 | -5.37e-01 | 0.0898 |
91074 | ANKRD30A | GSM4909296 | Human | Breast | IDC | 2.31e-20 | -5.37e-01 | 0.1524 |
91074 | ANKRD30A | GSM4909297 | Human | Breast | IDC | 1.84e-09 | 5.94e-01 | 0.1517 |
91074 | ANKRD30A | GSM4909298 | Human | Breast | IDC | 1.86e-34 | 5.89e-01 | 0.1551 |
91074 | ANKRD30A | GSM4909301 | Human | Breast | IDC | 3.33e-27 | 6.90e-01 | 0.1577 |
91074 | ANKRD30A | GSM4909302 | Human | Breast | IDC | 7.88e-29 | 8.02e-01 | 0.1545 |
91074 | ANKRD30A | GSM4909303 | Human | Breast | IDC | 1.17e-02 | 5.70e-01 | 0.0438 |
91074 | ANKRD30A | GSM4909304 | Human | Breast | IDC | 6.58e-19 | -5.37e-01 | 0.1636 |
91074 | ANKRD30A | GSM4909306 | Human | Breast | IDC | 1.33e-27 | 7.62e-01 | 0.1564 |
91074 | ANKRD30A | GSM4909307 | Human | Breast | IDC | 4.88e-14 | 5.32e-01 | 0.1569 |
91074 | ANKRD30A | GSM4909308 | Human | Breast | IDC | 6.33e-55 | 8.56e-01 | 0.158 |
91074 | ANKRD30A | GSM4909309 | Human | Breast | IDC | 1.51e-10 | -5.12e-01 | 0.0483 |
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Tissue | Expression Dynamics | Abbreviation |
Breast | ![]() | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ | ||
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKRD30A | SNV | Missense_Mutation | novel | c.830N>G | p.Glu277Gly | p.E277G | protein_coding | tolerated(0.1) | probably_damaging(0.932) | TCGA-RD-A7C1-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ANKRD30A | SNV | Missense_Mutation | c.440N>G | p.Lys147Arg | p.K147R | protein_coding | tolerated(0.76) | benign(0.131) | TCGA-VQ-A8PE-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | ||
ANKRD30A | SNV | Missense_Mutation | c.3431N>A | p.Pro1144His | p.P1144H | protein_coding | deleterious(0.02) | benign(0.009) | TCGA-VQ-A91A-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | ||
ANKRD30A | SNV | Missense_Mutation | novel | c.2664N>A | p.His888Gln | p.H888Q | protein_coding | tolerated(0.28) | benign(0.027) | TCGA-VQ-A922-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | |
ANKRD30A | insertion | Frame_Shift_Ins | novel | c.796_797insA | p.Thr268AsnfsTer3 | p.T268Nfs*3 | protein_coding | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |||
ANKRD30A | SNV | Missense_Mutation | c.1838A>T | p.Glu613Val | p.E613V | protein_coding | tolerated(0.08) | benign(0.108) | TCGA-EM-A2OX-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
ANKRD30A | insertion | Frame_Shift_Ins | novel | c.1127_1128insCACGT | p.Arg377ThrfsTer2 | p.R377Tfs*2 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
ANKRD30A | insertion | Frame_Shift_Ins | novel | c.1129_1130insATTTCTCAGATGTTTCTTTT | p.Arg377AsnfsTer9 | p.R377Nfs*9 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
ANKRD30A | insertion | In_Frame_Ins | novel | c.3547_3548insATTCCTCTTTCAGTT | p.Val1183delinsAspSerSerPheSerLeu | p.V1183delinsDSSFSL | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
ANKRD30A | insertion | Frame_Shift_Ins | novel | c.3551_3552insCATTGTGT | p.Ser1185IlefsTer26 | p.S1185Ifs*26 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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