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Gene: ZYG11B |
Gene summary for ZYG11B |
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Gene information | Species | Human | Gene symbol | ZYG11B | Gene ID | 79699 |
Gene name | zyg-11 family member B, cell cycle regulator | |
Gene Alias | ZYG11 | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | B4DK95 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79699 | ZYG11B | HTA11_347_2000001011 | Human | Colorectum | AD | 1.98e-09 | 4.69e-01 | -0.1954 |
79699 | ZYG11B | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.91e-03 | 4.13e-01 | -0.059 |
79699 | ZYG11B | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.40e-09 | 9.40e-01 | 0.0131 |
79699 | ZYG11B | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.34e-03 | 5.88e-01 | 0.0112 |
79699 | ZYG11B | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.69e-06 | 1.12e+00 | 0.3487 |
79699 | ZYG11B | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.77e-08 | 6.79e-01 | 0.281 |
79699 | ZYG11B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.71e-24 | 1.34e+00 | 0.3859 |
79699 | ZYG11B | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.31e-04 | 5.48e-01 | 0.2585 |
79699 | ZYG11B | A015-C-203 | Human | Colorectum | FAP | 3.83e-12 | -2.44e-01 | -0.1294 |
79699 | ZYG11B | A015-C-204 | Human | Colorectum | FAP | 1.35e-02 | -2.57e-01 | -0.0228 |
79699 | ZYG11B | A002-C-201 | Human | Colorectum | FAP | 5.82e-05 | -1.93e-01 | 0.0324 |
79699 | ZYG11B | A002-C-203 | Human | Colorectum | FAP | 2.31e-02 | -1.44e-01 | 0.2786 |
79699 | ZYG11B | A001-C-119 | Human | Colorectum | FAP | 1.80e-02 | -2.55e-01 | -0.1557 |
79699 | ZYG11B | A001-C-108 | Human | Colorectum | FAP | 6.07e-11 | -2.73e-01 | -0.0272 |
79699 | ZYG11B | A002-C-205 | Human | Colorectum | FAP | 1.67e-07 | -1.88e-01 | -0.1236 |
79699 | ZYG11B | A001-C-104 | Human | Colorectum | FAP | 1.01e-02 | -2.11e-01 | 0.0184 |
79699 | ZYG11B | A015-C-006 | Human | Colorectum | FAP | 1.45e-07 | -3.35e-01 | -0.0994 |
79699 | ZYG11B | A015-C-106 | Human | Colorectum | FAP | 6.44e-05 | -2.12e-01 | -0.0511 |
79699 | ZYG11B | A002-C-114 | Human | Colorectum | FAP | 2.24e-08 | -3.32e-01 | -0.1561 |
79699 | ZYG11B | A015-C-104 | Human | Colorectum | FAP | 1.53e-11 | -2.75e-01 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:1903362 | Colorectum | AD | regulation of cellular protein catabolic process | 109/3918 | 255/18723 | 2.14e-15 | 6.08e-13 | 109 |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
GO:1903050 | Colorectum | AD | regulation of proteolysis involved in cellular protein catabolic process | 92/3918 | 221/18723 | 2.04e-12 | 3.19e-10 | 92 |
GO:0045732 | Colorectum | AD | positive regulation of protein catabolic process | 92/3918 | 231/18723 | 3.85e-11 | 4.47e-09 | 92 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
GO:0045862 | Colorectum | AD | positive regulation of proteolysis | 129/3918 | 372/18723 | 4.04e-10 | 3.46e-08 | 129 |
GO:0061136 | Colorectum | AD | regulation of proteasomal protein catabolic process | 75/3918 | 187/18723 | 1.65e-09 | 1.20e-07 | 75 |
GO:2000058 | Colorectum | AD | regulation of ubiquitin-dependent protein catabolic process | 68/3918 | 164/18723 | 1.82e-09 | 1.31e-07 | 68 |
GO:1903364 | Colorectum | AD | positive regulation of cellular protein catabolic process | 62/3918 | 155/18723 | 4.66e-08 | 2.51e-06 | 62 |
GO:0032434 | Colorectum | AD | regulation of proteasomal ubiquitin-dependent protein catabolic process | 54/3918 | 134/18723 | 2.51e-07 | 1.02e-05 | 54 |
GO:1903052 | Colorectum | AD | positive regulation of proteolysis involved in cellular protein catabolic process | 53/3918 | 133/18723 | 4.93e-07 | 1.85e-05 | 53 |
GO:2000060 | Colorectum | AD | positive regulation of ubiquitin-dependent protein catabolic process | 44/3918 | 107/18723 | 1.65e-06 | 5.03e-05 | 44 |
GO:1901800 | Colorectum | AD | positive regulation of proteasomal protein catabolic process | 44/3918 | 114/18723 | 1.18e-05 | 2.62e-04 | 44 |
GO:0032436 | Colorectum | AD | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 36/3918 | 90/18723 | 2.89e-05 | 5.37e-04 | 36 |
GO:0006515 | Colorectum | AD | protein quality control for misfolded or incompletely synthesized proteins | 14/3918 | 28/18723 | 6.01e-04 | 6.33e-03 | 14 |
GO:00421761 | Colorectum | SER | regulation of protein catabolic process | 126/2897 | 391/18723 | 5.33e-17 | 2.52e-14 | 126 |
GO:19033621 | Colorectum | SER | regulation of cellular protein catabolic process | 91/2897 | 255/18723 | 1.22e-15 | 5.36e-13 | 91 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZYG11B | SNV | Missense_Mutation | novel | c.2152N>G | p.Ile718Val | p.I718V | Q9C0D3 | protein_coding | tolerated(0.07) | probably_damaging(0.996) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZYG11B | SNV | Missense_Mutation | rs780976980 | c.2182N>T | p.Arg728Cys | p.R728C | Q9C0D3 | protein_coding | deleterious(0.03) | possibly_damaging(0.736) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZYG11B | SNV | Missense_Mutation | rs373581677 | c.179N>A | p.Arg60Gln | p.R60Q | Q9C0D3 | protein_coding | tolerated(0.96) | benign(0) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZYG11B | SNV | Missense_Mutation | c.700N>T | p.Arg234Trp | p.R234W | Q9C0D3 | protein_coding | deleterious(0.01) | probably_damaging(0.976) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZYG11B | SNV | Missense_Mutation | novel | c.137N>T | p.Glu46Val | p.E46V | Q9C0D3 | protein_coding | deleterious(0) | possibly_damaging(0.649) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZYG11B | SNV | Missense_Mutation | novel | c.1744N>T | p.Asp582Tyr | p.D582Y | Q9C0D3 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZYG11B | SNV | Missense_Mutation | novel | c.1349N>C | p.Lys450Thr | p.K450T | Q9C0D3 | protein_coding | tolerated(0.14) | benign(0.017) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZYG11B | SNV | Missense_Mutation | c.898C>G | p.Leu300Val | p.L300V | Q9C0D3 | protein_coding | tolerated(0.12) | probably_damaging(0.978) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZYG11B | SNV | Missense_Mutation | c.570N>A | p.Ser190Arg | p.S190R | Q9C0D3 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZYG11B | SNV | Missense_Mutation | novel | c.1640N>C | p.Val547Ala | p.V547A | Q9C0D3 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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