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Gene: ZSCAN29 |
Gene summary for ZSCAN29 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZSCAN29 | Gene ID | 146050 |
Gene name | zinc finger and SCAN domain containing 29 | |
Gene Alias | ZNF690 | |
Cytomap | 15q15.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q05BJ4 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
146050 | ZSCAN29 | HCC1_Meng | Human | Liver | HCC | 1.86e-33 | 4.22e-02 | 0.0246 |
146050 | ZSCAN29 | HCC2_Meng | Human | Liver | HCC | 1.15e-08 | 6.26e-02 | 0.0107 |
146050 | ZSCAN29 | HCC1 | Human | Liver | HCC | 3.26e-04 | 2.30e+00 | 0.5336 |
146050 | ZSCAN29 | HCC2 | Human | Liver | HCC | 5.38e-12 | 2.95e+00 | 0.5341 |
146050 | ZSCAN29 | S015 | Human | Liver | HCC | 1.04e-02 | 1.21e-01 | 0.2375 |
146050 | ZSCAN29 | S016 | Human | Liver | HCC | 1.26e-06 | 2.14e-01 | 0.2243 |
146050 | ZSCAN29 | S027 | Human | Liver | HCC | 1.35e-04 | 4.57e-01 | 0.2446 |
146050 | ZSCAN29 | S028 | Human | Liver | HCC | 4.73e-18 | 5.09e-01 | 0.2503 |
146050 | ZSCAN29 | S029 | Human | Liver | HCC | 2.09e-09 | 3.21e-01 | 0.2581 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZSCAN29 | SNV | Missense_Mutation | c.317C>T | p.Ser106Leu | p.S106L | Q8IWY8 | protein_coding | tolerated(0.21) | benign(0.27) | TCGA-DM-A1D8-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZSCAN29 | SNV | Missense_Mutation | novel | c.2177N>T | p.Arg726Ile | p.R726I | Q8IWY8 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZSCAN29 | SNV | Missense_Mutation | rs369750925 | c.1417N>T | p.Arg473Trp | p.R473W | Q8IWY8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZSCAN29 | deletion | Frame_Shift_Del | c.1177delN | p.Gln393ArgfsTer102 | p.Q393Rfs*102 | Q8IWY8 | protein_coding | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
ZSCAN29 | deletion | Frame_Shift_Del | c.1643delN | p.Pro548GlnfsTer5 | p.P548Qfs*5 | Q8IWY8 | protein_coding | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
ZSCAN29 | deletion | Frame_Shift_Del | c.1177delN | p.Gln393ArgfsTer102 | p.Q393Rfs*102 | Q8IWY8 | protein_coding | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
ZSCAN29 | deletion | Frame_Shift_Del | c.1177delN | p.Gln393ArgfsTer102 | p.Q393Rfs*102 | Q8IWY8 | protein_coding | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |||
ZSCAN29 | SNV | Missense_Mutation | novel | c.1853N>T | p.Ala618Val | p.A618V | Q8IWY8 | protein_coding | tolerated(0.09) | benign(0.019) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZSCAN29 | SNV | Missense_Mutation | c.317N>T | p.Ser106Leu | p.S106L | Q8IWY8 | protein_coding | tolerated(0.21) | benign(0.27) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZSCAN29 | SNV | Missense_Mutation | c.364N>C | p.Thr122Pro | p.T122P | Q8IWY8 | protein_coding | tolerated(0.25) | benign(0.095) | TCGA-A5-A0GA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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