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Gene: ZNF721 |
Gene summary for ZNF721 |
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Gene information | Species | Human | Gene symbol | ZNF721 | Gene ID | 170960 |
Gene name | zinc finger protein 721 | |
Gene Alias | ZNF721 | |
Cytomap | 4p16.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8TF20 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
170960 | ZNF721 | CA_HPV_3 | Human | Cervix | CC | 1.91e-02 | 8.48e-02 | 0.0414 |
170960 | ZNF721 | CCI_1 | Human | Cervix | CC | 3.35e-04 | 7.43e-01 | 0.528 |
170960 | ZNF721 | CCI_2 | Human | Cervix | CC | 8.88e-03 | 5.72e-01 | 0.5249 |
170960 | ZNF721 | CCI_3 | Human | Cervix | CC | 2.07e-03 | 5.05e-01 | 0.516 |
170960 | ZNF721 | Tumor | Human | Cervix | CC | 5.33e-04 | -1.96e-01 | 0.1241 |
170960 | ZNF721 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.06e-12 | -5.08e-01 | 0.0155 |
170960 | ZNF721 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.35e-02 | -3.22e-01 | -0.1808 |
170960 | ZNF721 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.05e-04 | -4.99e-01 | -0.1207 |
170960 | ZNF721 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.34e-06 | -3.96e-01 | -0.1464 |
170960 | ZNF721 | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.00e-03 | -6.54e-01 | -0.2061 |
170960 | ZNF721 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.19e-06 | -4.68e-01 | 0.096 |
170960 | ZNF721 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.78e-05 | -3.69e-01 | 0.0674 |
170960 | ZNF721 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.08e-02 | -2.56e-01 | 0.294 |
170960 | ZNF721 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.70e-04 | -3.31e-01 | 0.3859 |
170960 | ZNF721 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.33e-05 | -6.37e-01 | 0.2585 |
170960 | ZNF721 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.01e-15 | -5.03e-01 | 0.3005 |
170960 | ZNF721 | A001-C-207 | Human | Colorectum | FAP | 1.01e-02 | -2.14e-01 | 0.1278 |
170960 | ZNF721 | A015-C-203 | Human | Colorectum | FAP | 1.23e-25 | -2.71e-01 | -0.1294 |
170960 | ZNF721 | A015-C-204 | Human | Colorectum | FAP | 5.75e-04 | -1.32e-01 | -0.0228 |
170960 | ZNF721 | A014-C-040 | Human | Colorectum | FAP | 6.08e-03 | -2.19e-01 | -0.1184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF721 | SNV | Missense_Mutation | c.1322G>T | p.Gly441Val | p.G441V | Q8TF20 | protein_coding | deleterious(0.01) | probably_damaging(0.979) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF721 | SNV | Missense_Mutation | c.839T>C | p.Leu280Ser | p.L280S | Q8TF20 | protein_coding | tolerated(0.42) | benign(0.403) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ZNF721 | SNV | Missense_Mutation | c.2096N>A | p.Cys699Tyr | p.C699Y | Q8TF20 | protein_coding | deleterious(0.02) | benign(0.024) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF721 | SNV | Missense_Mutation | rs373046971 | c.2658N>G | p.Ile886Met | p.I886M | Q8TF20 | protein_coding | deleterious(0) | possibly_damaging(0.802) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF721 | SNV | Missense_Mutation | rs369761887 | c.2224N>A | p.Glu742Lys | p.E742K | Q8TF20 | protein_coding | tolerated(1) | benign(0.039) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF721 | SNV | Missense_Mutation | novel | c.2345N>G | p.Lys782Arg | p.K782R | Q8TF20 | protein_coding | deleterious(0.03) | probably_damaging(0.935) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF721 | SNV | Missense_Mutation | novel | c.1899N>C | p.Lys633Asn | p.K633N | Q8TF20 | protein_coding | tolerated(0.06) | benign(0.291) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF721 | SNV | Missense_Mutation | c.2318N>C | p.Lys773Thr | p.K773T | Q8TF20 | protein_coding | tolerated(0.08) | probably_damaging(0.982) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF721 | SNV | Missense_Mutation | c.1184N>A | p.Gly395Asp | p.G395D | Q8TF20 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZNF721 | SNV | Missense_Mutation | c.2560N>A | p.Val854Ile | p.V854I | Q8TF20 | protein_coding | tolerated(0.22) | benign(0.103) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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