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Gene: ZNF704 |
Gene summary for ZNF704 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF704 | Gene ID | 619279 |
Gene name | zinc finger protein 704 | |
Gene Alias | Gig1 | |
Cytomap | 8q21.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6ZNC4 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
619279 | ZNF704 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.98e-29 | -7.78e-01 | 0.0155 |
619279 | ZNF704 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.78e-15 | -7.42e-01 | -0.1808 |
619279 | ZNF704 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.34e-04 | -8.07e-01 | 0.0216 |
619279 | ZNF704 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.60e-03 | -4.64e-01 | -0.0811 |
619279 | ZNF704 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.22e-02 | -6.04e-01 | -0.2196 |
619279 | ZNF704 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.04e-11 | -7.22e-01 | -0.1207 |
619279 | ZNF704 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.19e-03 | -2.79e-01 | -0.1464 |
619279 | ZNF704 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.04e-04 | -2.69e-01 | -0.1001 |
619279 | ZNF704 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.05e-07 | -4.81e-01 | -0.059 |
619279 | ZNF704 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.03e-05 | -7.20e-01 | -0.2061 |
619279 | ZNF704 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.65e-03 | -7.20e-01 | -0.1462 |
619279 | ZNF704 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.15e-13 | -5.56e-01 | 0.096 |
619279 | ZNF704 | HTA11_8622_2000001021 | Human | Colorectum | SER | 7.33e-06 | -7.53e-01 | 0.0528 |
619279 | ZNF704 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.35e-03 | -4.19e-01 | 0.0338 |
619279 | ZNF704 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.63e-10 | -3.88e-01 | 0.0674 |
619279 | ZNF704 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.04e-21 | -5.58e-01 | 0.294 |
619279 | ZNF704 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.89e-12 | -8.30e-01 | 0.2585 |
619279 | ZNF704 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.65e-33 | -7.83e-01 | 0.3005 |
619279 | ZNF704 | F007 | Human | Colorectum | FAP | 4.19e-03 | -1.91e-01 | 0.1176 |
619279 | ZNF704 | A015-C-203 | Human | Colorectum | FAP | 6.41e-23 | -3.66e-01 | -0.1294 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF704 | SNV | Missense_Mutation | rs200333415 | c.661N>T | p.Arg221Cys | p.R221C | Q6ZNC4 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF704 | SNV | Missense_Mutation | novel | c.293N>A | p.Pro98His | p.P98H | Q6ZNC4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
ZNF704 | SNV | Missense_Mutation | novel | c.886N>A | p.Pro296Thr | p.P296T | Q6ZNC4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF704 | SNV | Missense_Mutation | novel | c.800N>T | p.Thr267Ile | p.T267I | Q6ZNC4 | protein_coding | tolerated(0.58) | benign(0.003) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF704 | SNV | Missense_Mutation | rs765187914 | c.1082C>T | p.Ala361Val | p.A361V | Q6ZNC4 | protein_coding | tolerated(0.22) | benign(0) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF704 | SNV | Missense_Mutation | novel | c.1143N>T | p.Glu381Asp | p.E381D | Q6ZNC4 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-D1-A2G5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ZNF704 | SNV | Missense_Mutation | novel | c.410N>A | p.Ser137Asn | p.S137N | Q6ZNC4 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ZNF704 | insertion | Frame_Shift_Ins | novel | c.117_118insA | p.Ala40SerfsTer6 | p.A40Sfs*6 | Q6ZNC4 | protein_coding | TCGA-AP-A05O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
ZNF704 | insertion | Frame_Shift_Ins | novel | c.416dupA | p.Ser140ValfsTer13 | p.S140Vfs*13 | Q6ZNC4 | protein_coding | TCGA-AP-A0LH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | PD | ||
ZNF704 | deletion | Frame_Shift_Del | novel | c.1151delN | p.Lys384SerfsTer59 | p.K384Sfs*59 | Q6ZNC4 | protein_coding | TCGA-AP-A1E1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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