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Gene: ZNF641 |
Gene summary for ZNF641 |
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Gene information | Species | Human | Gene symbol | ZNF641 | Gene ID | 121274 |
Gene name | zinc finger protein 641 | |
Gene Alias | ZNF641 | |
Cytomap | 12q13.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q96N77 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
121274 | ZNF641 | male-WTA | Human | Thyroid | PTC | 3.58e-09 | 9.83e-02 | 0.1037 |
121274 | ZNF641 | PTC04 | Human | Thyroid | PTC | 5.02e-07 | 1.29e-01 | 0.1927 |
121274 | ZNF641 | PTC06 | Human | Thyroid | PTC | 6.79e-13 | 2.17e-01 | 0.2057 |
121274 | ZNF641 | PTC07 | Human | Thyroid | PTC | 3.50e-08 | 1.50e-01 | 0.2044 |
121274 | ZNF641 | ATC13 | Human | Thyroid | ATC | 1.79e-27 | 5.16e-01 | 0.34 |
121274 | ZNF641 | ATC5 | Human | Thyroid | ATC | 3.03e-25 | 5.58e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF641 | SNV | Missense_Mutation | rs563221165 | c.1283N>A | p.Arg428Gln | p.R428Q | Q96N77 | protein_coding | tolerated(0.33) | benign(0) | TCGA-86-8056-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF641 | SNV | Missense_Mutation | novel | c.1187N>T | p.Gly396Val | p.G396V | Q96N77 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-63-A5MU-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
ZNF641 | deletion | Frame_Shift_Del | novel | c.900_901delNN | p.Phe301TrpfsTer16 | p.F301Wfs*16 | Q96N77 | protein_coding | TCGA-22-1005-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
ZNF641 | SNV | Missense_Mutation | novel | c.301N>G | p.Leu101Val | p.L101V | Q96N77 | protein_coding | deleterious(0.04) | benign(0.333) | TCGA-CQ-A4CD-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF641 | SNV | Missense_Mutation | novel | c.488A>G | p.Glu163Gly | p.E163G | Q96N77 | protein_coding | tolerated(0.07) | benign(0.005) | TCGA-CR-7398-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF641 | SNV | Missense_Mutation | c.811A>G | p.Lys271Glu | p.K271E | Q96N77 | protein_coding | deleterious(0) | benign(0.242) | TCGA-CV-6003-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZNF641 | SNV | Missense_Mutation | rs144784236 | c.659C>T | p.Pro220Leu | p.P220L | Q96N77 | protein_coding | deleterious(0) | possibly_damaging(0.52) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF641 | SNV | Missense_Mutation | novel | c.32N>G | p.Ser11Cys | p.S11C | Q96N77 | protein_coding | tolerated_low_confidence(0.1) | benign(0) | TCGA-VP-AA1N-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
ZNF641 | SNV | Missense_Mutation | c.830N>T | p.Ser277Phe | p.S277F | Q96N77 | protein_coding | deleterious(0) | benign(0.293) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF641 | SNV | Missense_Mutation | c.1312T>C | p.Phe438Leu | p.F438L | Q96N77 | protein_coding | tolerated_low_confidence(0.16) | benign(0.22) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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